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Revising Your Manuscript

When revising your manuscript we’ll ask you to provide several new items in Editorial Manager.

  1. A response to reviewers. Upload as a Response to Reviewers file.
  2. A clean copy of your revised manuscript. Upload as a Manuscript file.
  3. A track changes version of your revised manuscript. Upload as a Revised Article with Changes Highlighted file.
  4. Revised figures and supporting information. Upload as Figure or Supporting Information files.
  5. A short blurb summarizing your study. Enter into the submission form as text.

Your figure files, supporting information, and other information will remain the same unless you choose to update or replace them.

Response to Reviewers

In your response to reviewers explain how you have addressed the issues identified during peer review. Present a point-by-point response to all of the editor’s and reviewers' comments and list the changes to the manuscript. Be sure to include the full context for each reviewer recommendation and revision; do not selectively quote sections from the reviews to respond to. Remember, if you choose to publish the peer review history of your manuscript, your response to reviewers will appear online alongside the final article.

Revised Manuscript File

Provide both a clean copy and a track changes version of your updated manuscript. If you are submitting a minor revision be sure to apply all journal formatting requirements.

Updating a preprint

If you chose to post your manuscript on bioRxiv during PLOS full submission, you may update or revise your preprint directly on bioRxiv at any time. Consult the bioRxiv submit page for specific instructions.


Write a short, appealing statement summarizing your research, about 20-30 words or 1-2 sentences long. If your submission is accepted for publication we’ll include your blurb in emails to our readers, and on the journal homepage.

Your blurb should, without exaggeration, entice people to read your manuscript. Make sure that it is not redundant with the title and does not include acronyms or abbreviations. The blurb is subject to editorial changes.


During embryonic development of the motor system of Drosophila, motorneurons target their dendrites to different regions along the body axis in response to midline guidance cues.

A neuroimaging study reveals novel insights into how the brain responds to an anticipated event, such as a starting gun or responding to a green light.

Computational modeling and experimentation in a model system for actin-based force generation explain how actin networks initiate and maintain directional movement.

For further examples, view the blurbs accompanying the articles on the PLOS Biology homepage.