PLOS partners with Cold Spring Harbor Laboratory to make posting preprints in the life sciences easy and convenient. All PLOS Biology research articles are eligible for preprints, with the exception of preregistered research articles.
Authors posting preprints to the bioRxiv preprint server can choose to concurrently submit their manuscripts to PLOS Biology and other relevant PLOS journals through the direct transfer service. Learn more about posting a preprint and the direct transfer service offered by bioRxiv.
Authors submitting manuscripts in the life sciences to PLOS Biology may opt-in to have PLOS forward their submission to bioRxiv for consideration for posting as a preprint.
Papers that pass an initial screening for suitability will be posted on bioRxiv as a preprint, meaning that the manuscript files will be made publicly available and credited to the listed authors. If the article is later accepted for publication in PLOS Biology, the preprint and published article will link to each other when the article appears online.
Preprints appear on bioRxiv in PDF format. Authors can choose to supply their own preprint PDF or have PLOS Biology compile an automatically generated PDF.
- If you supply a preprint PDF it will appear on bioRxiv unchanged. Be sure to include title, authors, abstract, and the full text of the manuscript, along with any figures or tables and their captions. bioRxiv limits PDF file size to 40 MB or less. PDF files must be compressed to meet this requirement.
- Alternatively, PLOS Biology can automatically compile a preprint PDF suitable for bioRxiv from the manuscript file and figure files that are part of your journal submission. Supplementary information will not be included in auto-generated preprints, but may be uploaded directly to bioRxiv after posting.
After authors have opted in to have their preprint posted by PLOS Biology, it is transferred to bioRxiv where researchers with relevant expertise screen preprint submissions for suitability. More information on the screening process can be found on the bioRxiv site.
Most submissions that pass the servers’ preprint checks will be posted within a few days of submission. Authors will receive a notification of successful preprint posting directly from bioRxiv. Once posted, a preprint cannot be removed from bioRxiv.
bioRxiv will communicate with authors directly if issues arise or screening indicates that a manuscript is not eligible for posting.
To ensure that readers are always accessing the latest version of the manuscript, authors are encouraged to submit updates and revisions to bioRxiv directly up until the point of acceptance for publication. Consult the submission guide at bioRxiv for specific instructions.
If a concern arises about a published PLOS article with a related preprint, PLOS will evaluate the concern according to our standard editorial processes, taking into account any relevant comments available on the preprint.