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Table of Contents

August 2022

Cover

Host genotype controls ecological change in the leaf fungal microbiome
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Leaf fungal microbiomes can be fundamental drivers of host plant success, as they contain pathogens that devastate crop plants and taxa that enhance nutrient uptake, discourage herbivory, and antagonize pathogens. VanWallwendael et al. measured leaf fungal diversity with amplicon sequencing across an entire growing season in a diversity panel of switchgrass (Panicum virgatum). They also sampled a replicated subset of genotypes across three additional sites to compare the importance of time, space, ecology, and genetics. The authors found a strong successional pattern in the microbiome shaped both by host genetics and environmental factors. Fungal pathogens were central to microbial covariance networks, and genotypes susceptible to pathogens differed in their expression of three cysteine-rich receptor-like kinases, suggesting that host immune genes are a principal means of controlling the entire leaf microbiome. The image shows a cross-section of a switchgrass leaf infected with rust fungus (Puccinia novopanici).

Image Credit: Raiza J Castillo Argaez

Consensus Views

The EICAT+ framework enables classification of positive impacts of alien taxa on native biodiversity

Giovanni Vimercati, Anna F. Probert, Lara Volery, Ruben Bernardo-Madrid, Sandro Bertolino, Vanessa Céspedes, Franz Essl, Thomas Evans, Belinda Gallardo, Laure Gallien, Pablo González-Moreno, Marie Charlotte Grange, Cang Hui, Jonathan M. Jeschke, Stelios Katsanevakis, Ingolf Kühn, Sabrina Kumschick, Jan Pergl, Petr Pyšek, Loren Rieseberg, Tamara B. Robinson, Wolf-Christian Saul, Cascade J. B. Sorte, Montserrat Vilà, John R. U. Wilson, Sven Bacher

PLOS Biology: published August 16, 2022 | https://doi.org/10.1371/journal.pbio.3001729

Designing and implementing a research integrity promotion plan: Recommendations for research funders

Serge P. J. M. Horbach, Lex M. Bouter, George Gaskell, Maura Hiney, Panagiotis Kavouras, Niels Mejlgaard, Nick Allum, Noémie Aubert Bonn, Anna-Kathrine Bendtsen, Costas A. Charitidis, Nik Claesen, Kris Dierickx, Anna Domaradzka, Andrea Reyes Elizondo, Nicole Föger, Wolfgang Kaltenbrunner, Teodora Konach, Krishma Labib, Ana Marušić, Daniel Pizzolato, Tine Ravn, Rea Roje, Mads P. Sørensen, Borana Taraj, Giuseppe A. Veltri, Joeri K. Tijdink

PLOS Biology: published August 19, 2022 | https://doi.org/10.1371/journal.pbio.3001773

Perspective

Urgent need for a non-discriminatory and non-stigmatizing nomenclature for monkeypox virus

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PLOS Biology: published August 23, 2022 | https://doi.org/10.1371/journal.pbio.3001769

Primers

The changing influence of host genetics on the leaf fungal microbiome throughout plant development

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PLOS Biology: published August 12, 2022 | https://doi.org/10.1371/journal.pbio.3001748

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Community Page

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Research Articles

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PLOS Biology: published August 30, 2022 | https://doi.org/10.1371/journal.pbio.3001707

Host genotype controls ecological change in the leaf fungal microbiome

Acer VanWallendael, Gian Maria Niccolo Benucci, Pedro Beschoren da Costa, Linnea Fraser, Avinash Sreedasyam, Felix Fritschi, Thomas E. Juenger, John T. Lovell, Gregory Bonito, David B. Lowry

PLOS Biology: published August 11, 2022 | https://doi.org/10.1371/journal.pbio.3001681

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Single-cell multiomics analyses of spindle-transferred human embryos suggest a mostly normal embryonic development

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Shoot-to-root translocated GmNN1/FT2a triggers nodulation and regulates soybean nitrogen nutrition

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Type 2 diabetes disrupts circadian orchestration of lipid metabolism and membrane fluidity in human pancreatic islets

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Macrophages take up VLDL-sized emulsion particles through caveolae-mediated endocytosis and excrete part of the internalized triglycerides as fatty acids

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Short Reports

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PLOS Biology: published August 23, 2022 | https://doi.org/10.1371/journal.pbio.3001733

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Genome-wide association studies of global Mycobacterium tuberculosis resistance to 13 antimicrobials in 10,228 genomes identify new resistance mechanisms

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PLOS Biology: published August 9, 2022 | https://doi.org/10.1371/journal.pbio.3001755

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Wnt5a–Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions

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Apoptosis and tissue thinning contribute to symmetric cell division in the developing mouse epidermis in a nonautonomous way

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PLOS Biology: published August 15, 2022 | https://doi.org/10.1371/journal.pbio.3001756

Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells

Yanshan Zhu, Keng Yih Chew, Melanie Wu, Anjana C. Karawita, Georgina McCallum, Lauren E. Steele, Ayaho Yamamoto, Larisa I. Labzin, Tejasri Yarlagadda, Alexander A. Khromykh, Xiaohui Wang, Julian D. J. Sng, Claudia J. Stocks, Yao Xia, Tobias R. Kollmann, David Martino, Merja Joensuu, Frédéric A. Meunier, Giuseppe Balistreri, Helle Bielefeldt-Ohmann, Asha C. Bowen, Anthony Kicic, Peter D. Sly, Kirsten M. Spann, Kirsty R. Short

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Methods and Resources

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Update Article

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PLOS Biology: published August 17, 2022 | https://doi.org/10.1371/journal.pbio.3001762

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