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Table of Contents

December 2012

Cover

A striated fiber is required for daughter cell budding in Toxoplasma gondii.

Issue Image

This immunofluorescence image shows humans fibroblasts infected with a mutant of the intracellular parasite Toxoplasma gondii. This mutant fails to express the striated fiber protein TgSFA3, and as a consequence does not initiate daughter cell formation during mitosis. Note that in this mutant, parasite cells contain two nuclei. Nuclei are shown in blue, and the outline of the parasites is shown in green with a red apical cap (pellicle components IMC1 and ISP1, respectively). See Francia et al. (e1001444) in this issue.

Image Credit: Maria Francia & Boris Striepen, University of Georgia.

Synopses

Which Came First: Burden of Infectious Disease or Poverty?

Jonathan Chase

PLOS Biology: published December 27, 2012 | https://doi.org/10.1371/journal.pbio.1001457

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Resurrecting an Ancient Enzyme to Address Gene Duplication

Richard Robinson

PLOS Biology: published December 11, 2012 | https://doi.org/10.1371/journal.pbio.1001447

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How HIV Sneaks aboard Mature Dendritic Cells

Caitlin Sedwick

PLOS Biology: published December 18, 2012 | https://doi.org/10.1371/journal.pbio.1001454

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Equal Inheritance: Genome Management for Proliferating Parasites

Stephanie Huang

PLOS Biology: published December 11, 2012 | https://doi.org/10.1371/journal.pbio.1001445

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Primer

Functional Amyloidogenesis and Cytotoxicity—Insights into Biology and Pathology

Douglas M. Fowler, Jeffery W. Kelly

PLOS Biology: published December 27, 2012 | https://doi.org/10.1371/journal.pbio.1001459

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Community Pages

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Hina Kalra, Richard J. Simpson, Hong Ji, Elena Aikawa, Peter Altevogt, Philip Askenase, Vincent C. Bond, Francesc E. Borràs, Xandra Breakefield, Vivian Budnik, Edit Buzas, Giovanni Camussi, Aled Clayton, Emanuele Cocucci, Juan M. Falcon-Perez, Susanne Gabrielsson, Yong Song Gho, Dwijendra Gupta, H. C. Harsha, An Hendrix, Andrew F. Hill, Jameel M. Inal, Guido Jenster, Eva-Maria Krämer-Albers, Sai Kiang Lim, Alicia Llorente, Jan Lötvall, Antonio Marcilla, Lucia Mincheva-Nilsson, Irina Nazarenko, Rienk Nieuwland, Esther N. M. Nolte-'t Hoen, Akhilesh Pandey, Tushar Patel, Melissa G. Piper, Stefano Pluchino, T. S. Keshava Prasad, Lawrence Rajendran, Graca Raposo, Michel Record, Gavin E. Reid, Francisco Sánchez-Madrid, Raymond M. Schiffelers, Pia Siljander, Allan Stensballe, Willem Stoorvogel, Douglas Taylor, Clotilde Thery, Hadi Valadi, Bas W. M. van Balkom, Jesús Vázquez, Michel Vidal, Marca H. M. Wauben, María Yáñez-Mó, Margot Zoeller, Suresh Mathivanan

PLOS Biology: published December 18, 2012 | https://doi.org/10.1371/journal.pbio.1001450

The Human Brain Online: An Open Resource for Advancing Brain Research

Sara Ball, Terri L. Gilbert, Caroline C. Overly

PLOS Biology: published December 27, 2012 | https://doi.org/10.1371/journal.pbio.1001453

Research Articles

Disease Ecology, Biodiversity, and the Latitudinal Gradient in Income

Matthew H. Bonds, Andrew P. Dobson, Donald C. Keenan

PLOS Biology: published December 27, 2012 | https://doi.org/10.1371/journal.pbio.1001456

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PLOS Biology: published December 11, 2012 | https://doi.org/10.1371/journal.pbio.1001446

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A Species-Specific Cluster of Defensin-Like Genes Encodes Diffusible Pollen Tube Attractants in Arabidopsis

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Nuria Izquierdo-Useros, Maier Lorizate, Maria C. Puertas, Maria T. Rodriguez-Plata, Nadine Zangger, Elina Erikson, Maria Pino, Itziar Erkizia, Bärbel Glass, Bonaventura Clotet, Oliver T. Keppler, Amalio Telenti, Hans-Georg Kräusslich, Javier Martinez-Picado

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ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer

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Growth Cone MKK7 mRNA Targeting Regulates MAP1b-Dependent Microtubule Bundling to Control Neurite Elongation

Daniel Feltrin, Ludovico Fusco, Harald Witte, Francesca Moretti, Katrin Martin, Michel Letzelter, Erika Fluri, Peter Scheiffele, Olivier Pertz

PLOS Biology: published December 4, 2012 | https://doi.org/10.1371/journal.pbio.1001439

The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

Xin Xiong, Yan Hao, Kan Sun, Jiaxing Li, Xia Li, Bibhudatta Mishra, Pushpanjali Soppina, Chunlai Wu, Richard I. Hume, Catherine A. Collins

PLOS Biology: published December 4, 2012 | https://doi.org/10.1371/journal.pbio.1001440

Cell Division in Apicomplexan Parasites Is Organized by a Homolog of the Striated Rootlet Fiber of Algal Flagella

Maria E. Francia, Carly N. Jordan, Jay D. Patel, Lilach Sheiner, Jessica L. Demerly, Justin D. Fellows, Jessica Cruz de Leon, Naomi S. Morrissette, Jean-François Dubremetz, Boris Striepen

PLOS Biology: published December 11, 2012 | https://doi.org/10.1371/journal.pbio.1001444

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PLOS Biology: published December 4, 2012 | https://doi.org/10.1371/journal.pbio.1001438

The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility

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