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Table of Contents

January 2011

Cover

The first virus naturally infecting Caenorhabditis elegans.

Issue Image

A rotten apple was the source of virally infected C. elegans, as reported in this issue by Félix et al. (e1000586). The small pictures making up the photomosaic show Caenorhabditis nematodes, some of which are infected as revealed by FISH staining of viral RNA. C. elegans mounts a small-RNA response that acts in antiviral defense, and this immune response varies among C. elegans wild isolates.

Image Credit: Marie-Anne Félix and Alyson Ashe.

Editorial

Common Disease: Are Causative Alleles Common or Rare?

Robert Shields

PLOS Biology: published January 18, 2011 | https://doi.org/10.1371/journal.pbio.1001009

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Synopsis

Nematodes Go Viral

Robin Meadows

PLOS Biology: published January 25, 2011 | https://doi.org/10.1371/journal.pbio.1001011

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  1. Natural and Experimental Infection of Caenorhabditis Nematodes by Novel Viruses Related to Nodaviruses

Perspectives

Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals

Carl A. Anderson, Nicole Soranzo, Eleftheria Zeggini, Jeffrey C. Barrett

PLOS Biology: published January 18, 2011 | https://doi.org/10.1371/journal.pbio.1000580

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Synthetic Associations Created by Rare Variants Do Not Explain Most GWAS Results

Naomi R. Wray, Shaun M. Purcell, Peter M. Visscher

PLOS Biology: published January 18, 2011 | https://doi.org/10.1371/journal.pbio.1000579

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The Importance of Synthetic Associations Will Only Be Resolved Empirically

David B. Goldstein

PLOS Biology: published January 18, 2011 | https://doi.org/10.1371/journal.pbio.1001008

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Community Page

Using the Game of Mastermind to Teach, Practice, and Discuss Scientific Reasoning Skills

Amy R. Strom, Scott Barolo

PLOS Biology: published January 18, 2011 | https://doi.org/10.1371/journal.pbio.1000578

Research Articles

Natural and Experimental Infection of Caenorhabditis Nematodes by Novel Viruses Related to Nodaviruses

Marie-Anne Félix, Alyson Ashe, Joséphine Piffaretti, Guang Wu, Isabelle Nuez, Tony Bélicard, Yanfang Jiang, Guoyan Zhao, Carl J. Franz, Leonard D. Goldstein, Mabel Sanroman, Eric A. Miska, David Wang

PLOS Biology: published January 25, 2011 | https://doi.org/10.1371/journal.pbio.1000586

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  1. Nematodes Go Viral

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLOS Biology: published January 18, 2011 | https://doi.org/10.1371/journal.pbio.1000582

Clusters of Temporal Discordances Reveal Distinct Embryonic Patterning Mechanisms in Drosophila and Anopheles

Dmitri Papatsenko, Michael Levine, Yury Goltsev

PLOS Biology: published January 25, 2011 | https://doi.org/10.1371/journal.pbio.1000584

The Gene Regulatory Cascade Linking Proneural Specification with Differentiation in Drosophila Sensory Neurons

Sebastián Cachero, T. Ian Simpson, Petra I. zur Lage, Lina Ma, Fay G. Newton, Eimear E. Holohan, J. Douglas Armstrong, Andrew P. Jarman

PLOS Biology: published January 4, 2011 | https://doi.org/10.1371/journal.pbio.1000568

Laminar Analysis of Excitatory Local Circuits in Vibrissal Motor and Sensory Cortical Areas

B. M. Hooks, S. Andrew Hires, Ying-Xin Zhang, Daniel Huber, Leopoldo Petreanu, Karel Svoboda, Gordon M. G. Shepherd

PLOS Biology: published January 4, 2011 | https://doi.org/10.1371/journal.pbio.1000572

Epigenetic Regulation of Learning and Memory by Drosophila EHMT/G9a

Jamie M. Kramer, Korinna Kochinke, Merel A. W. Oortveld, Hendrik Marks, Daniela Kramer, Eiko K. de Jong, Zoltan Asztalos, J. Timothy Westwood, Hendrik G. Stunnenberg, Marla B. Sokolowski, Krystyna Keleman, Huiqing Zhou, Hans van Bokhoven, Annette Schenck

PLOS Biology: published January 4, 2011 | https://doi.org/10.1371/journal.pbio.1000569

Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System

Qiang Liu, Juan Zhang, Celina Zerbinatti, Yan Zhan, Benedict J. Kolber, Joachim Herz, Louis J. Muglia, Guojun Bu

PLOS Biology: published January 11, 2011 | https://doi.org/10.1371/journal.pbio.1000575

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Evidence of Activity-Specific, Radial Organization of Mitotic Chromosomes in Drosophila

Yuri G. Strukov, Tûba H. Sural, Mitzi I. Kuroda, John W. Sedat

PLOS Biology: published January 11, 2011 | https://doi.org/10.1371/journal.pbio.1000574

Analysis of LhcSR3, a Protein Essential for Feedback De-Excitation in the Green Alga Chlamydomonas reinhardtii

Giulia Bonente, Matteo Ballottari, Thuy B. Truong, Tomas Morosinotto, Tae K. Ahn, Graham R. Fleming, Krishna K. Niyogi, Roberto Bassi

PLOS Biology: published January 18, 2011 | https://doi.org/10.1371/journal.pbio.1000577

The In Vivo Kinetics of RNA Polymerase II Elongation during Co-Transcriptional Splicing

Yehuda Brody, Noa Neufeld, Nicole Bieberstein, Sebastien Z. Causse, Eva-Maria Böhnlein, Karla M. Neugebauer, Xavier Darzacq, Yaron Shav-Tal

PLOS Biology: published January 11, 2011 | https://doi.org/10.1371/journal.pbio.1000573

SecM-Stalled Ribosomes Adopt an Altered Geometry at the Peptidyl Transferase Center

Shashi Bhushan, Thomas Hoffmann, Birgit Seidelt, Jens Frauenfeld, Thorsten Mielke, Otto Berninghausen, Daniel N. Wilson, Roland Beckmann

PLOS Biology: published January 18, 2011 | https://doi.org/10.1371/journal.pbio.1000581

Book Review%2FScience in the Media

Are We Really Getting Conservation So Badly Wrong?

Kathy MacKinnon

PLOS Biology: published January 25, 2011 | https://doi.org/10.1371/journal.pbio.1001010