Disrupting phage liquid crystalline droplets restores antibiotic susceptibility in Pseudomonas aeruginosa biofilms

• Abul K. Tarafder ,

  Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: atarafder@mrclmb.ac.uk (AKT); tbharat@mrclmb.ac.uk (TAMB)

  Affiliation Structural Studies Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, United Kingdom

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• Miles Graham ,

  Contributed equally to this work with: Miles Graham, Luke K. Davis

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Structural Studies Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, United Kingdom

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• Luke K. Davis ,

  Contributed equally to this work with: Miles Graham, Luke K. Davis

  Roles Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations School of Mathematics, University of Edinburgh, Edinburgh, United Kingdom, Higgs Centre for Theoretical Physics, University of Edinburgh, Edinburgh, United Kingdom, Department of Mathematics, University College London, London, United Kingdom

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• Shawna Pratt,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

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• Jan Böhning,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Structural Studies Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, United Kingdom

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• Pavithra Manivannan,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Structural Studies Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, United Kingdom

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• Zhexin Wang,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Structural Studies Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, United Kingdom

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• Camila M. Clemente,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Structural Studies Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, United Kingdom

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• Aaron Weimann,

  Roles Investigation, Writing – review & editing

  Affiliations Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge, United Kingdom, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom, Cambridge Centre for AI in Medicine, University of Cambridge, Cambridge, United Kingdom

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• R. Andres Floto,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliations Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge, United Kingdom, Cambridge Centre for AI in Medicine, University of Cambridge, Cambridge, United Kingdom, Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge, United Kingdom

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• Raymond J. Owens,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliations Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Rosalind Franklin Institute, Harwell Science Campus, Didcot, United Kingdom

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• George A. O’Toole,

  Roles Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

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• Philip Pearce,

  Roles Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Mathematics, University College London, London, United Kingdom, Institute for the Physics of Living Systems, University College London, London, United Kingdom

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• Tanmay A. M. Bharat

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: atarafder@mrclmb.ac.uk (AKT); tbharat@mrclmb.ac.uk (TAMB)

  Affiliation Structural Studies Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, United Kingdom

  https://orcid.org/0000-0002-0168-0277

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