Glia-to-glia serotonin signaling directs MMP-dependent infiltration for experience-dependent synapse pruning

Vanessa Kay Miller; Kendal Broadie

doi:10.1371/journal.pbio.3003524

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Glia-to-glia serotonin signaling directs MMP-dependent infiltration for experience-dependent synapse pruning

Vanessa Kay Miller,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Biological Sciences, Vanderbilt University and Medical Center, Nashville, Tennessee United States of America
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Kendal Broadie

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: kendal.broadie@vanderbilt.edu

Affiliations Department of Biological Sciences, Vanderbilt University and Medical Center, Nashville, Tennessee United States of America, Department of Cell and Developmental Biology, Vanderbilt University and Medical Center, Nashville, Tennessee, United States of America, Department of Pharmacology, Vanderbilt University and Medical Center, Nashville, Tennessee, United States of America, Kennedy Center for Research on Human Development, Vanderbilt University and Medical Center, Nashville, Tennessee, United States of America, Vanderbilt Brain Institute, Vanderbilt University and Medical Center, Nashville, Tennessee, United States of America

https://orcid.org/0000-0003-3783-6023

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Glia-to-glia serotonin signaling directs MMP-dependent infiltration for experience-dependent synapse pruning

Vanessa Kay Miller,
Kendal Broadie

Published: December 1, 2025
https://doi.org/10.1371/journal.pbio.3003524

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