MK-8527 is a novel inhibitor of HIV-1 reverse transcriptase translocation with potential for extended-duration dosing

• Izzat T. Raheem ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: izzat_raheem@merck.com (ITR); tracy_diamond@merck.com (TLD)

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

  https://orcid.org/0000-0002-6769-8816

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• Vinay Girijavallabhan,

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Kerry L. Fillgrove,

  Roles Data curation, Formal analysis, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Shih Lin Goh,

  Roles Data curation, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Carolyn Bahnck-Teets,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Qian Huang,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Fangbiao Li,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Bang-Lin Wan,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Gregory T. O’Donnell,

  Roles Methodology

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Jonathan B. Patteson,

  Roles Methodology

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Maria E. Cilento,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Amrith Bennet ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Visualization, Writing – review & editing

  ¶‡ An employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, New Jersey, United States of America, at the time the study was conducted.

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Robert P. Hayes,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Visualization, Writing – review & editing

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Srivanya Tummala ,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  ¶‡ An employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, New Jersey, United States of America, at the time the study was conducted.

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Carolyn McHale,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Judyann Wiltsie,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Joan Ellis,

  Roles Investigation, Methodology, Resources

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Ernest Asante-Appiah,

  Roles Conceptualization, Project administration, Supervision

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Daria J. Hazuda ,

  Roles Investigation, Project administration, Resources, Supervision, Writing – review & editing

  ¶‡ An employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, New Jersey, United States of America, at the time the study was conducted.

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Jeffrey Hale ,

  Roles Conceptualization, Resources, Supervision

  ¶‡ An employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, New Jersey, United States of America, at the time the study was conducted.

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Jay A. Grobler ,

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  ¶‡ An employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, New Jersey, United States of America, at the time the study was conducted.

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Min Xu ,

  Roles Investigation, Methodology, Resources, Supervision

  ¶‡ An employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, New Jersey, United States of America, at the time the study was conducted.

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Tracy L. Diamond ,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: izzat_raheem@merck.com (ITR); tracy_diamond@merck.com (TLD)

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

  https://orcid.org/0000-0002-4672-8641

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•  [ ... ],
• Ming-Tain Lai

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

  ¶‡ An employee of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, New Jersey, United States of America, at the time the study was conducted.

  Affiliation Merck & Co., Inc., Rahway, New Jersey, United States of America

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