The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury

• Qingxiu Zhang ,

  Contributed equally to this work with: Qingxiu Zhang, Wen Zhu

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Current address: Department of Neurology, Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China

  Affiliation Pittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Wen Zhu ,

  Contributed equally to this work with: Qingxiu Zhang, Wen Zhu

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliation Pittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Fei Xu,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliations Pittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Xuejiao Dai,

  Roles Formal analysis, Investigation, Validation

  Affiliation Pittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Ligen Shi,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliation Pittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Wei Cai,

  Roles Formal analysis, Investigation, Visualization

  Affiliation Pittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Hongfeng Mu,

  Roles Investigation

  Affiliation Pittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• T. Kevin Hitchens,

  Roles Data curation, Investigation, Methodology

  Affiliations Animal Imaging Center, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0001-6576-6742

  ⨯
• Lesley M. Foley,

  Roles Investigation, Methodology

  Affiliation Animal Imaging Center, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0001-7752-2139

  ⨯
• Xiangrong Liu,

  Roles Investigation

  Affiliation Pittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Fang Yu,

  Roles Investigation

  Affiliation Pittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0003-4317-5698

  ⨯
• Jie Chen,

  Roles Funding acquisition, Investigation, Validation, Writing – review & editing

  Affiliation Pittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0002-6890-1695

  ⨯
• Yejie Shi,

  Roles Investigation

  Affiliation Pittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0001-7502-9201

  ⨯
• Rehana K. Leak,

  Roles Data curation, Writing – review & editing

  Affiliation Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0003-2817-7417

  ⨯
• Yanqin Gao,

  Roles Investigation

  Affiliation Pittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Jun Chen ,

  Roles Conceptualization, Supervision

  * E-mail: hux2@upmc.edu (XH); chenj2@upmc.edu (JC)

  Affiliations Pittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania, United States of America

  ⨯
•  [ ... ],
• Xiaoming Hu

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: hux2@upmc.edu (XH); chenj2@upmc.edu (JC)

  Affiliations Pittsburgh Institute of Brain Disorders and Recovery, and Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0002-5857-6243

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