Single-Cell-Based Analysis Highlights a Surge in Cell-to-Cell Molecular Variability Preceding Irreversible Commitment in a Differentiation Process

• Angélique Richard,

  Affiliation Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d’Italie Site Jacques Monod, F-69007, Lyon, France

  http://orcid.org/0000-0002-5440-8656

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• Loïs Boullu,

  Affiliations Inria Team Dracula, Inria Center Grenoble Rhône-Alpes, France, Université de Lyon, Université Lyon 1, CNRS UMR 5208, Institut Camille Jordan 43 blvd du 11 novembre 1918, F-69622 Villeurbanne-Cedex, France, Département de Mathématiques et de statistiques de l’Université de Montréal, Pavillon André-Aisenstadt, 2920, chemin de la Tour, Montréal (Québec) H3T 1J4 Canada

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• Ulysse Herbach,

  Affiliations Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d’Italie Site Jacques Monod, F-69007, Lyon, France, Inria Team Dracula, Inria Center Grenoble Rhône-Alpes, France, Université de Lyon, Université Lyon 1, CNRS UMR 5208, Institut Camille Jordan 43 blvd du 11 novembre 1918, F-69622 Villeurbanne-Cedex, France

  http://orcid.org/0000-0002-0972-385X

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• Arnaud Bonnafoux,

  Affiliations Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d’Italie Site Jacques Monod, F-69007, Lyon, France, Inria Team Dracula, Inria Center Grenoble Rhône-Alpes, France, The CoSMo company. 5 passage du Vercors – 69007 LYON – France

  http://orcid.org/0000-0003-0472-0761

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• Valérie Morin,

  Affiliation Univ Lyon, Univ Claude Bernard, CNRS UMR 5310 - INSERM U1217, Institut NeuroMyoGène, F-69622 Villeurbanne-Cedex, France

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• Elodie Vallin,

  Affiliation Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d’Italie Site Jacques Monod, F-69007, Lyon, France

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• Anissa Guillemin,

  Affiliation Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d’Italie Site Jacques Monod, F-69007, Lyon, France

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• Nan Papili Gao,

  Affiliations Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland, Swiss Institute of Bioinformatics, Quartier Sorge - Batiment Genopode, 1015 Lausanne Switzerland

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• Rudiyanto Gunawan,

  Affiliations Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland, Swiss Institute of Bioinformatics, Quartier Sorge - Batiment Genopode, 1015 Lausanne Switzerland

  http://orcid.org/0000-0002-6480-7976

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• Jérémie Cosette,

  Affiliation Genethon – Institut National de la Santé et de la Recherche Médicale – INSERM, Université d’Evry-Val-d’Essone – 1 rue de l’internationale 91000 Evry, France

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• Ophélie Arnaud,

  Affiliation RIKEN - Center for Life Science Technologies (Division of Genomic Technologies)—CLST (DGT), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

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• Jean-Jacques Kupiec,

  Affiliation INSERM, Centre Cavaillès, Ecole Normale Supérieure, F-75005 Paris, France

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• Thibault Espinasse,

  Affiliation Université de Lyon, Université Lyon 1, CNRS UMR 5208, Institut Camille Jordan 43 blvd du 11 novembre 1918, F-69622 Villeurbanne-Cedex, France

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• Sandrine Gonin-Giraud ,

  Contributed equally to this work with: Sandrine Gonin-Giraud, Olivier Gandrillon

  Affiliation Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d’Italie Site Jacques Monod, F-69007, Lyon, France

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• Olivier Gandrillon

  Contributed equally to this work with: Sandrine Gonin-Giraud, Olivier Gandrillon

  * E-mail: Olivier.Gandrillon@ens-lyon.fr

  Affiliations Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d’Italie Site Jacques Monod, F-69007, Lyon, France, Inria Team Dracula, Inria Center Grenoble Rhône-Alpes, France

  http://orcid.org/0000-0002-3676-6513

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