About the Authors

Angélique Richard

Affiliation Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d’Italie Site Jacques Monod, F-69007, Lyon, France

Loïs Boullu

Affiliations Inria Team Dracula, Inria Center Grenoble Rhône-Alpes, France, Université de Lyon, Université Lyon 1, CNRS UMR 5208, Institut Camille Jordan 43 blvd du 11 novembre 1918, F-69622 Villeurbanne-Cedex, France, Département de Mathématiques et de statistiques de l’Université de Montréal, Pavillon André-Aisenstadt, 2920, chemin de la Tour, Montréal (Québec) H3T 1J4 Canada

Ulysse Herbach

Affiliations Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d’Italie Site Jacques Monod, F-69007, Lyon, France, Inria Team Dracula, Inria Center Grenoble Rhône-Alpes, France, Université de Lyon, Université Lyon 1, CNRS UMR 5208, Institut Camille Jordan 43 blvd du 11 novembre 1918, F-69622 Villeurbanne-Cedex, France

Arnaud Bonnafoux

Affiliations Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d’Italie Site Jacques Monod, F-69007, Lyon, France, Inria Team Dracula, Inria Center Grenoble Rhône-Alpes, France, The CoSMo company. 5 passage du Vercors – 69007 LYON – France

Valérie Morin

Affiliation Univ Lyon, Univ Claude Bernard, CNRS UMR 5310 - INSERM U1217, Institut NeuroMyoGène, F-69622 Villeurbanne-Cedex, France

Elodie Vallin

Affiliation Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d’Italie Site Jacques Monod, F-69007, Lyon, France

Anissa Guillemin

Affiliation Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d’Italie Site Jacques Monod, F-69007, Lyon, France

Nan Papili Gao

Affiliations Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland, Swiss Institute of Bioinformatics, Quartier Sorge - Batiment Genopode, 1015 Lausanne Switzerland

Rudiyanto Gunawan

Affiliations Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland, Swiss Institute of Bioinformatics, Quartier Sorge - Batiment Genopode, 1015 Lausanne Switzerland

Jérémie Cosette

Affiliation Genethon – Institut National de la Santé et de la Recherche Médicale – INSERM, Université d’Evry-Val-d’Essone – 1 rue de l’internationale 91000 Evry, France

Ophélie Arnaud

Affiliation RIKEN - Center for Life Science Technologies (Division of Genomic Technologies)—CLST (DGT), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

Jean-Jacques Kupiec

Affiliation INSERM, Centre Cavaillès, Ecole Normale Supérieure, F-75005 Paris, France

Thibault Espinasse

Affiliation Université de Lyon, Université Lyon 1, CNRS UMR 5208, Institut Camille Jordan 43 blvd du 11 novembre 1918, F-69622 Villeurbanne-Cedex, France

Sandrine Gonin-Giraud

Contributed equally to this work with: Sandrine Gonin-Giraud, Olivier Gandrillon

Affiliation Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d’Italie Site Jacques Monod, F-69007, Lyon, France

Olivier Gandrillon

Contributed equally to this work with: Sandrine Gonin-Giraud, Olivier Gandrillon

Olivier.Gandrillon@ens-lyon.fr

Affiliations Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d’Italie Site Jacques Monod, F-69007, Lyon, France, Inria Team Dracula, Inria Center Grenoble Rhône-Alpes, France

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: OG UH AB AR SGG JJK NPG RG JC. Formal analysis: AR LB UH AB NPG RG TE OG. Funding acquisition: OG SGG. Investigation: AR VM EV AG OA. Supervision: OG SGG. Writing – original draft: AR SGG OG. Writing – review & editing: OG AR SGG JJK LB JC RG NPG.