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Open Access
Peer-reviewed
Research Article
A Voltage-Gated Calcium Channel Regulates Lysosomal Fusion with Endosomes and Autophagosomes and Is Required for Neuronal Homeostasis
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Xuejun Tian ,
Contributed equally to this work with: Xuejun Tian, Upasana Gala
Affiliation Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou, China
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Upasana Gala ,
Contributed equally to this work with: Xuejun Tian, Upasana Gala
Affiliation Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America
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Yongping Zhang,
Affiliation Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou, China
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Weina Shang,
Affiliation Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou, China
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Sonal Nagarkar Jaiswal,
Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
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Alberto di Ronza,
Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, United States of America
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Manish Jaiswal,
Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America
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Shinya Yamamoto,
Affiliations Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, United States of America
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Hector Sandoval,
Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, United States of America
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Lita Duraine,
Affiliation Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America
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Marco Sardiello,
Affiliations Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, United States of America
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Roy V. Sillitoe,
Affiliations Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, United States of America, Department of Pathology and Immunology, Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America
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Kartik Venkatachalam,
Affiliations Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Integrative Biology and Pharmacology, University of Texas School of Medicine, Houston, Texas, United States of America
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Hengyu Fan,
Affiliation Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou, China
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Hugo J. Bellen ,
* E-mail: ctong@zju.edu.cn (CT), hbellen@bcm.edu (HJB)
Affiliations Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, United States of America, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America, Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America
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Chao Tong
* E-mail: ctong@zju.edu.cn (CT), hbellen@bcm.edu (HJB)
Affiliation Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou, China
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A Voltage-Gated Calcium Channel Regulates Lysosomal Fusion with Endosomes and Autophagosomes and Is Required for Neuronal Homeostasis
- Xuejun Tian,
- Upasana Gala,
- Yongping Zhang,
- Weina Shang,
- Sonal Nagarkar Jaiswal,
- Alberto di Ronza,
- Manish Jaiswal,
- Shinya Yamamoto,
- Hector Sandoval,
- Lita Duraine
- Published: March 26, 2015
- https://doi.org/10.1371/journal.pbio.1002103