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Open Access
Peer-reviewed
Research Article
ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer
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Maria Kalyuga ,
¶DGO and MK contributed equally to this work and are joint first authors.
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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David Gallego-Ortega ,
¶DGO and MK contributed equally to this work and are joint first authors.
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
⨯ -
Heather J. Lee,
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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Daniel L. Roden,
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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Mark J. Cowley,
Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, Peter Wills Bioinformatics Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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C. Elizabeth Caldon,
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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Andrew Stone,
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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Stephanie L. Allerdice,
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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Fatima Valdes-Mora,
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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Rosalind Launchbury,
Affiliation Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom
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Aaron L. Statham,
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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Nicola Armstrong,
Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, School of Mathematics and Statistics, and Prince of Wales Clinical School, University of New South Wales Kensington NSW, Australia
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M. Chehani Alles,
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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Adelaide Young,
Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, University of Bath, Bath, United Kingdom
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Andrea Egger,
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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Wendy Au,
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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Catherine L. Piggin,
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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Cara J. Evans,
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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Anita Ledger,
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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Tilman Brummer,
Current address: Institute for Molecular Medicine and Cell Research, Freiburg, Germany
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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Samantha R. Oakes,
Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
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Warren Kaplan,
Affiliations Peter Wills Bioinformatics Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia
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Julia M. W. Gee,
Affiliation Breast Cancer (Molecular Pharmacology) Group, Cardiff School of Pharmacy and Pharmaceutical Science, Cardiff University, Cardiff, Wales, United Kingdom
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Robert I. Nicholson,
Affiliation Breast Cancer (Molecular Pharmacology) Group, Cardiff School of Pharmacy and Pharmaceutical Science, Cardiff University, Cardiff, Wales, United Kingdom
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Robert L. Sutherland †,
† Deceased.
Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia
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Alexander Swarbrick,
Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia
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Matthew J. Naylor,
Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia, Discipline of Physiology & Bosch Institute, School of Medical Sciences, University of Sydney, NSW, Australia
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Susan J. Clark,
Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia
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Jason S. Carroll,
Affiliation Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom
⨯ - [ ... ],
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Christopher J. Ormandy
* E-mail: c.ormandy@garvan.org.au
Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia
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ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer
- Maria Kalyuga,
- David Gallego-Ortega,
- Heather J. Lee,
- Daniel L. Roden,
- Mark J. Cowley,
- C. Elizabeth Caldon,
- Andrew Stone,
- Stephanie L. Allerdice,
- Fatima Valdes-Mora,
- Rosalind Launchbury
- Published: December 27, 2012
- https://doi.org/10.1371/journal.pbio.1001461