About the Authors

Maria Kalyuga

DGO and MK contributed equally to this work and are joint first authors.

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

David Gallego-Ortega

DGO and MK contributed equally to this work and are joint first authors.

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Heather J. Lee

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Daniel L. Roden

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Mark J. Cowley

Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, Peter Wills Bioinformatics Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

C. Elizabeth Caldon

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Andrew Stone

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Stephanie L. Allerdice

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Fatima Valdes-Mora

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Rosalind Launchbury

Affiliation Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom

Aaron L. Statham

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Nicola Armstrong

Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, School of Mathematics and Statistics, and Prince of Wales Clinical School, University of New South Wales Kensington NSW, Australia

M. Chehani Alles

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Adelaide Young

Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, University of Bath, Bath, United Kingdom

Andrea Egger

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Wendy Au

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Catherine L. Piggin

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Cara J. Evans

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Anita Ledger

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Tilman Brummer

Current address: Institute for Molecular Medicine and Cell Research, Freiburg, Germany

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Samantha R. Oakes

Affiliation Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Warren Kaplan

Affiliations Peter Wills Bioinformatics Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia

Julia M. W. Gee

Affiliation Breast Cancer (Molecular Pharmacology) Group, Cardiff School of Pharmacy and Pharmaceutical Science, Cardiff University, Cardiff, Wales, United Kingdom

Robert I. Nicholson

Affiliation Breast Cancer (Molecular Pharmacology) Group, Cardiff School of Pharmacy and Pharmaceutical Science, Cardiff University, Cardiff, Wales, United Kingdom

Robert L. Sutherland

† Deceased.

Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia

Alexander Swarbrick

Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia

Matthew J. Naylor

Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia, Discipline of Physiology & Bosch Institute, School of Medical Sciences, University of Sydney, NSW, Australia

Susan J. Clark

Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia

Jason S. Carroll

Affiliation Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom

Christopher J. Ormandy

c.ormandy@garvan.org.au

Affiliations Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: MK DGO HJL SRO CEC CA TB ASw MJN, JSC CJO. Performed the experiments: MK DGO HL CEC SLA FVM RL ASto CA AY AE WA CP CE AL. Analyzed the data: MK DGO HL MC CEC ASto SLA FVM RL ASw NA CA DR AY AE WA CP CE AL WK JMWG ASta MJNSC JSC CJO. Contributed reagents/materials/analysis tools: RIN RLS. Wrote the paper: All authors.