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Open Access
Peer-reviewed
Research Article
Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome
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Ingrid van der Pluijm ,
Contributed equally to this work with: Ingrid van der Pluijm, George A Garinis
Affiliation Department of Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
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George A Garinis ,
Contributed equally to this work with: Ingrid van der Pluijm, George A Garinis
Affiliation Department of Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
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Renata M. C Brandt,
Affiliation Department of Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
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Theo G. M. F Gorgels,
Current address: Department of Molecular Ophthalmology, Netherlands Ophthalmic Research Institute, Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands
Affiliation Department of Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
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Susan W Wijnhoven,
Affiliation National Institute of Public Health and the Environment (RIVM), Laboratory of Toxicology, Pathology and Genetics (TOX), Bilthoven, The Netherlands
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Karin E. M Diderich,
Affiliation Department of Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
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Jan de Wit,
Affiliation Department of Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
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James R Mitchell,
Affiliation Department of Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
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Conny van Oostrom,
Affiliation National Institute of Public Health and the Environment (RIVM), Laboratory of Toxicology, Pathology and Genetics (TOX), Bilthoven, The Netherlands
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Rudolf Beems,
Affiliation National Institute of Public Health and the Environment (RIVM), Laboratory of Toxicology, Pathology and Genetics (TOX), Bilthoven, The Netherlands
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Laura J Niedernhofer,
Current address: University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America
Affiliation Department of Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
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Susana Velasco,
Affiliation Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
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Errol C Friedberg,
Affiliation Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
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Kiyoji Tanaka,
Affiliation Division of Cellular Genetics, Institute for Molecular and Cellular Biology, Osaka University, Osaka, Japan
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Harry van Steeg,
Affiliation National Institute of Public Health and the Environment (RIVM), Laboratory of Toxicology, Pathology and Genetics (TOX), Bilthoven, The Netherlands
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Jan H. J Hoeijmakers,
Affiliation Department of Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
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Gijsbertus T. J van der Horst
*To whom correspondence should be addressed. E-mail: g.vanderhorst@erasmusmc.nl
Affiliation Department of Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
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Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome
- Ingrid van der Pluijm,
- George A Garinis,
- Renata M. C Brandt,
- Theo G. M. F Gorgels,
- Susan W Wijnhoven,
- Karin E. M Diderich,
- Jan de Wit,
- James R Mitchell,
- Conny van Oostrom,
- Rudolf Beems
- Published: December 12, 2006
- https://doi.org/10.1371/journal.pbio.0050002