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Macromolecular engineering

Engineering of long-acting human growth hormone-Fc fusion proteins: Effects of valency, fusion position, and linker design on pharmacokinetics and efficacy

Taekyeol Lee, Dongsop Lee, [ ... ], Jaehoon Choi

Semi-rational evolution of a recombinant DNA polymerase for modified nucleotide incorporation efficiency

Lili Zhai, Zi Wang, [ ... ], Yuliang Dong

A systematic in vitro study of the effect of normoglycaemic and hyperglycaemic conditions on the biochemical and cellular interactions of clinically-available wound dressings with different physicochemical properties

Shirin Saberianpour, Gianluca Melotto, [ ... ], Matteo Santin

A percolation theory analysis of continuous functional paths in protein sequence space affirms previous insights on the optimization of proteins for adaptability

Brian J. Miller

Effects of selection stringency on the outcomes of directed evolution

Berk A. Alpay, Michael M. Desai

Identifying widespread and recurrent variants of genetic parts to improve annotation of engineered DNA sequences

Matthew J. McGuffie, Jeffrey E. Barrick

An engineered thermally tolerant apo-cytochrome scaffold for metal-less incorporation of heme derivative

Sami Ben Aoun, Sheikh Muhammad Ibrahim

Computational design of novel nanobodies targeting the receptor binding domain of variants of concern of SARS-CoV-2

Phoomintara Longsompurana, Thanyada Rungrotmongkol, [ ... ], Rungtiva P. Poo-arporn

Simultaneous prediction of antibody backbone and side-chain conformations with deep learning

Deniz Akpinaroglu, Jeffrey A. Ruffolo, Sai Pooja Mahajan, Jeffrey J. Gray

Computational design of Lactobacillus Acidophilus α-L-rhamnosidase to increase its structural stability

Thassanai Sitthiyotha, Methus Klaewkla, [ ... ], Surasak Chunsrivirot

Heuristic algorithms in evolutionary computation and modular organization of biological macromolecules: Applications to in vitro evolution

Alexander V. Spirov, Ekaterina M. Myasnikova

Fluorinated oil-surfactant mixtures with the density of water: Artificial cells for synthetic biology

Roberto Laos, Steven Benner

The register shift rules for βαβ-motifs for de novo protein design

Hiroto Murata, Hayao Imakawa, Nobuyasu Koga, George Chikenji

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