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Macromolecular engineering

Rosetta:MSF:NN: Boosting performance of multi-state computational protein design with a neural network

Julian Nazet, Elmar Lang, Rainer Merkl

Discovery of potent and specific inhibitors targeting the active site of MMP-9 from the engineered SPINK2 library

Hidenori Yano, Daisuke Nishimiya, [ ... ], Ryuji Hashimoto

5,5-Dialkylluciferins are thermal stable substrates for bioluminescence-based detection systems

Ce Shi, Michael P. Killoran, [ ... ], Thomas A. Kirkland

Improved yellow-green split fluorescent proteins for protein labeling and signal amplification

Shuqin Zhou, Siyu Feng, David Brown, Bo Huang

SMOOT libraries and phage-induced directed evolution of Cas9 to engineer reduced off-target activity

Derek Cerchione, Katherine Loveluck, [ ... ], Barrett E. Steinberg

Substrate structure and computation guided engineering of a lipase for omega-3 fatty acid selectivity

Tushar Ranjan Moharana, Nalam Madhusudhana Rao

Bottom-up synthesis of protein-based nanomaterials from engineered β-solenoid proteins

Zeyu Peng, Maria D. R. Peralta, Daniel L. Cox, Michael D. Toney

Occurrence and stability of hetero-hexamer associations formed by β-carboxysome CcmK shell components

Luis F. Garcia-Alles, Katharina Root, [ ... ], Gilles Truan

Posterior ventral tegmental area-nucleus accumbens shell circuitry modulates response to novelty

Hailong Li, Jessica M. Illenberger, [ ... ], Rosemarie M. Booze

Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody

Zenjiro Sampei, Kenta Haraya, [ ... ], Junichi Nezu

The scale-free nature of protein sequence space

Patrick C. F. Buchholz, Catharina Zeil, Jürgen Pleiss

Next generation calmodulin affinity purification: Clickable calmodulin facilitates improved protein purification

Julia G. Fraseur, Tamara L. Kinzer-Ursem

Fn3 proteins engineered to recognize tumor biomarker mesothelin internalize upon binding

Allison R. Sirois, Daniela A. Deny, [ ... ], Sarah J. Moore

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