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Protein engineering

Engineering of long-acting human growth hormone-Fc fusion proteins: Effects of valency, fusion position, and linker design on pharmacokinetics and efficacy

Taekyeol Lee, Dongsop Lee, [ ... ], Jaehoon Choi

A percolation theory analysis of continuous functional paths in protein sequence space affirms previous insights on the optimization of proteins for adaptability

Brian J. Miller

Effects of selection stringency on the outcomes of directed evolution

Berk A. Alpay, Michael M. Desai

An engineered thermally tolerant apo-cytochrome scaffold for metal-less incorporation of heme derivative

Sami Ben Aoun, Sheikh Muhammad Ibrahim

Computational design of novel nanobodies targeting the receptor binding domain of variants of concern of SARS-CoV-2

Phoomintara Longsompurana, Thanyada Rungrotmongkol, [ ... ], Rungtiva P. Poo-arporn

Simultaneous prediction of antibody backbone and side-chain conformations with deep learning

Deniz Akpinaroglu, Jeffrey A. Ruffolo, Sai Pooja Mahajan, Jeffrey J. Gray

Heuristic algorithms in evolutionary computation and modular organization of biological macromolecules: Applications to in vitro evolution

Alexander V. Spirov, Ekaterina M. Myasnikova

Fluorinated oil-surfactant mixtures with the density of water: Artificial cells for synthetic biology

Roberto Laos, Steven Benner

Discovery of potent and specific inhibitors targeting the active site of MMP-9 from the engineered SPINK2 library

Hidenori Yano, Daisuke Nishimiya, [ ... ], Ryuji Hashimoto

5,5-Dialkylluciferins are thermal stable substrates for bioluminescence-based detection systems

Ce Shi, Michael P. Killoran, [ ... ], Thomas A. Kirkland

Improved yellow-green split fluorescent proteins for protein labeling and signal amplification

Shuqin Zhou, Siyu Feng, David Brown, Bo Huang

SMOOT libraries and phage-induced directed evolution of Cas9 to engineer reduced off-target activity

Derek Cerchione, Katherine Loveluck, [ ... ], Barrett E. Steinberg

Substrate structure and computation guided engineering of a lipase for omega-3 fatty acid selectivity

Tushar Ranjan Moharana, Nalam Madhusudhana Rao

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