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Computational biology

Integrative multi-omics and machine learning identify CHRNA1 putative circadian-immune hub in COPD

Lan Zhang, Zhifei Li, [ ... ], Kaiyu Han

Integrated transcriptomic analysis of LMB2-induced podocyte injury identifies conserved inflammatory and adaptive stress responses

Mohammad-Reza Esmaeili, Marjan Nejati, [ ... ], Sara Taleahmad

Leveraging expression quantitative trait loci information in single-cell resolution to identify cell-specific genes for gestational diabetes

Wenyan Zhu, Xiaowei Wu, Rongkui Hu

Exploratory identification of candidate SNP markers associated with recurrent clinical mastitis in Holstein cattle

Shiho Miyata, Lijie Fan, [ ... ], Kentaro Nagaoka

Structural analysis of recombinant AAV vector genomes at single-molecule resolution

David Rouleau, Dimpal Lata, [ ... ], Ifeyinwa Iwuchukwu

Glutamate administration is associated with aggravated atherosclerosis and altered expression of RAPGEF1, OPN, and MYL7 in High-Fat Diet-Fed ApoE⁻/⁻ Mice

Xiuli Cheng, Fanshu Dai, [ ... ], Biao Zhang

Population genomics of Nigerian goat breeds and neighbouring populations in the West Africa–Cameroon transboundary livestock corridor

Oludayo Michael Akinsola, Olusegun Olaniyi Adeniyi, [ ... ], Abdulraheem Arome Musa

Virtual screening of Kocuria oceani AT-1 metabolites as potential maize growth regulators under drought conditions using molecular docking and dynamics simulation

Muhammad Usama, Mahwish Salman, Ghulam Mustafa

Integrated computational analysis identifies FABP4, PTGS2, and HPGD as Key molecular targets linking PET microplastic exposure to metabolic dysfunction-associated steatotic liver disease

Yi Zhang, Yao Yu, [ ... ], Peng Chen

EPAS1 knockdown is associated with cell cycle and DNA replication programs and MYC/E2F-related signatures in hemangioma endothelial cells

Zheren Su, Luying Wang, [ ... ], Ran Huo

Improving performance of polygenic risk scores for hypertension across two ancestry groups

Marguerite R. Irvin, Vinodh Srinivasasainagendra, [ ... ], Hemant K. Tiwari

Breast cancer clustering integrating complete gene expression profiles and genetic ancestry

Johanna Stepanian, Alejandro Mejia-Garcia, Carlos Orozco, Jorge Duitama

Long noncoding RNA Gpr137b-ps mediates 15-PGDH-induced angiogenesis in brain microvasculature following tMCAO in mice

Di Wang, Guojian Zhang, [ ... ], Yujuan Jiao

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