The image shows multiple C. elegans young adult hermaphrodites with a 3ʹUTR deletion mutation in the pos-1 gene. POS-1 protein is colored in cyan and PGL-1 protein is colored in purple. One worm in the middle of the field appears to lack both POS-1 and PGL-1. This animal displays the partially penetrant sterility phenotype caused by failure to maintain the germline in the pos-1 3ʹUTR deletion mutation. Varderesian et al. 2026
Image Credit: Haik Varderesian and Sean Ryder
Review
Why recombination hotspots?
PLOS Genetics: published May 19, 2026 | https://doi.org/10.1371/journal.pgen.1012152
Research Articles
KAT6A is essential for developmental control gene expression in neural stem and progenitor cells
PLOS Genetics: published May 4, 2026 | https://doi.org/10.1371/journal.pgen.1012133
Tissue-specific transfer learning improves functional variant and therapeutic target discoveries in breast and prostate cancer
PLOS Genetics: published May 6, 2026 | https://doi.org/10.1371/journal.pgen.1012145
Tumour-driven lipid accumulation in oenocytes reflects systemic lipid alterations
PLOS Genetics: published May 7, 2026 | https://doi.org/10.1371/journal.pgen.1012150
Simulated sample splitting approach to address biases due to instrument selection and participant overlap in two-sample Mendelian Randomization studies
PLOS Genetics: published May 8, 2026 | https://doi.org/10.1371/journal.pgen.1011949
Design and interpretation of eQTL-GWAS colocalisation studies: Lessons from a large-scale evaluation
PLOS Genetics: published May 8, 2026 | https://doi.org/10.1371/journal.pgen.1012141
Spatiotemporal characterization of single-stranded DNA Intermediates after UV Irradiation: I: Post-replication gaps formed during slow growth
PLOS Genetics: published May 14, 2026 | https://doi.org/10.1371/journal.pgen.1012109
Spatiotemporal characterization of single-stranded DNA intermediates after UV irradiation: II. Rapid growth and effects of recA and recJ
PLOS Genetics: published May 14, 2026 | https://doi.org/10.1371/journal.pgen.1012110
Cas9-expressing HC-04 hepatocytes facilitate CRISPR-based analysis of Plasmodium falciparum sporozoite-host interactions
PLOS Genetics: published May 18, 2026 | https://doi.org/10.1371/journal.pgen.1012137
An intronic variant in Ferredoxin Reductase (FDXR) creates a cryptic exon in Quarter Horses with Equine Juvenile Spinocerebellar Ataxia
PLOS Genetics: published May 20, 2026 | https://doi.org/10.1371/journal.pgen.1012158
Comparative whole-genome analyses of articular chondrocytes and skin fibroblasts reveal distinct genome instability landscapes in mesenchymal cell types
PLOS Genetics: published May 20, 2026 | https://doi.org/10.1371/journal.pgen.1012156
MR2G: A novel framework for causal network inference using GWAS summary data
PLOS Genetics: published May 26, 2026 | https://doi.org/10.1371/journal.pgen.1012144
ZBP1 Drives CD8+ T cell-mediated anti-tumor immunity in head and neck squamous cell carcinoma
PLOS Genetics: published May 26, 2026 | https://doi.org/10.1371/journal.pgen.1012107
Pre-cuticle DPY-6 acts as a blueprint for aECM periodic organization in C. elegans
PLOS Genetics: published May 26, 2026 | https://doi.org/10.1371/journal.pgen.1012168
FabF and FadM cooperate to recycle fatty acids and rescue ∆plsX lethality in Staphylococcus aureus
PLOS Genetics: published May 27, 2026 | https://doi.org/10.1371/journal.pgen.1012165
mFABIO: An integrative multi-tissue TWAS fine-mapping approach to prioritize potentially causal genes and tissues underlying binary traits
PLOS Genetics: published May 27, 2026 | https://doi.org/10.1371/journal.pgen.1012157
Predicting antifolate resistance in the unculturable fungal pathogen Pneumocystis jirovecii
PLOS Genetics: published May 27, 2026 | https://doi.org/10.1371/journal.pgen.1012163
Yap1 regulates motility and vertebral development and prevents kyphoscoliosis in zebrafish
PLOS Genetics: published May 28, 2026 | https://doi.org/10.1371/journal.pgen.1012172
Species-specific coevolution of RecA–RecN interfaces governs DNA double-strand break repair in Escherichia coli
PLOS Genetics: published May 28, 2026 | https://doi.org/10.1371/journal.pgen.1012169
Corrections
Correction: The foraging gene coordinates brain and heart networks to modulate socially cued interval timing in Drosophila
PLOS Genetics: published May 5, 2026 | https://doi.org/10.1371/journal.pgen.1012140
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Correction: Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses
PLOS Genetics: published May 19, 2026 | https://doi.org/10.1371/journal.pgen.1012155
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Correction: Alanine-scanning mutagenesis library of MreB reveals distinct roles for regulating cell shape and viability
PLOS Genetics: published May 20, 2026 | https://doi.org/10.1371/journal.pgen.1012154