June 2023

This photo shows the importance of conserving crop wild relatives that grow in natural habitats. The subject of the photo is a wild kumquat shrub, bearing small, orange fruit, that naturally occurs in mountainous areas. Crop wild relatives like this wild kumquat can be valuable genetic resources for improving cultivated crops through plant breeding. This photo highlights the vulnerability of wild kumquat populations and reminds us of the need to take action to conserve these valuable genetic resources for future use in agricultural improvement and ensuring global food security. Download June's cover page.

Image Credit: Nan Wang

Review

Steroid hormone regulation of innate immunity in Drosophila melanogaster

Scott A. Keith

PLOS Genetics: published June 15, 2023 | https://doi.org/10.1371/journal.pgen.1010782

Research Articles

The circadian clock is disrupted in pancreatic cancer

Patrick B. Schwartz, Manabu Nukaya, Mark E. Berres, Clifford D. Rubinstein, Gang Wu, John B. Hogenesch, Christopher A. Bradfield, Sean M. Ronnekleiv-Kelly

PLOS Genetics: published June 1, 2023 | https://doi.org/10.1371/journal.pgen.1010770

Overlapping functions of SIX homeoproteins during embryonic myogenesis

Maud Wurmser, Rouba Madani, Nathalie Chaverot, Stéphanie Backer, Matthew Borok, Matthieu Dos Santos, Glenda Comai, Shahragim Tajbakhsh, Frédéric Relaix, Marc Santolini, Ramkumar Sambasivan, Rulang Jiang, Pascal Maire

PLOS Genetics: published June 2, 2023 | https://doi.org/10.1371/journal.pgen.1010781

A polycistronic transgene design for combinatorial genetic perturbations from a single transcript in Drosophila

Alexander G. Teague, Maria Quintero, Fateme Karimi Dermani, Ross L. Cagan, Erdem Bangi

PLOS Genetics: published June 2, 2023 | https://doi.org/10.1371/journal.pgen.1010792

Combinations of genes at the 16p11.2 and 22q11.2 CNVs contribute to neurobehavioral traits

Mikhail Vysotskiy, Autism Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Lauren A. Weiss

PLOS Genetics: published June 2, 2023 | https://doi.org/10.1371/journal.pgen.1010780

The novel anti-phage system Shield co-opts an RmuC domain to mediate phage defense across Pseudomonas species

Elliot Macdonald, Rosanna Wright, James P. R. Connolly, Henrik Strahl, Michael Brockhurst, Stineke van Houte, Tim R. Blower, Tracy Palmer, Giuseppina Mariano

PLOS Genetics: published June 5, 2023 | https://doi.org/10.1371/journal.pgen.1010784

Spatio-temporal transcriptome dynamics coordinate rapid transition of core crop functions in ‘lactating’ pigeon

Yujie Wang, Xun Wang, Yi Luo, Jiaman Zhang, Yu Lin, Jie Wu, Bo Zeng, Lei Liu, Peiqi Yan, Jiyuan Liang, Hongrui Guo, Long Jin, Qianzi Tang, Keren Long, Mingzhou Li

PLOS Genetics: published June 8, 2023 | https://doi.org/10.1371/journal.pgen.1010746

Mapping genetic effects on cell type-specific chromatin accessibility and annotating complex immune trait variants using single nucleus ATAC-seq in peripheral blood

Paola Benaglio, Jacklyn Newsome, Jee Yun Han, Joshua Chiou, Anthony Aylward, Sierra Corban, Michael Miller, Mei-Lin Okino, Jaspreet Kaur, Sebastian Preissl, David U. Gorkin, Kyle J. Gaulton

PLOS Genetics: published June 8, 2023 | https://doi.org/10.1371/journal.pgen.1010759

Retrotransposon LINE-1 bodies in the cytoplasm of piRNA-deficient mouse spermatocytes: Ribonucleoproteins overcoming the integrated stress response

Chiara De Luca, Anuj Gupta, Alex Bortvin

PLOS Genetics: published June 12, 2023 | https://doi.org/10.1371/journal.pgen.1010797

Memory phase-specific genes in the Mushroom Bodies identified using CrebB-target DamID

Noemi Sgammeglia, Yves F. Widmer, Jenifer C. Kaldun, Cornelia Fritsch, Rémy Bruggmann, Simon G. Sprecher

PLOS Genetics: published June 12, 2023 | https://doi.org/10.1371/journal.pgen.1010802

Mutators can drive the evolution of multi-resistance to antibiotics

Danna R. Gifford, Ernesto Berríos-Caro, Christine Joerres, Marc Suñé, Jessica H. Forsyth, Anish Bhattacharyya, Tobias Galla, Christopher G. Knight

PLOS Genetics: published June 13, 2023 | https://doi.org/10.1371/journal.pgen.1010791

Development of AlissAID system targeting GFP or mCherry fusion protein

Yoshitaka Ogawa, Kohei Nishimura, Keisuke Obara, Takumi Kamura

PLOS Genetics: published June 14, 2023 | https://doi.org/10.1371/journal.pgen.1010731

IFT74 variants cause skeletal ciliopathy and motile cilia defects in mice and humans

Zeineb Bakey, Oscar A. Cabrera, Julia Hoefele, Dinu Antony, Kaman Wu, Michael W. Stuck, Dimitra Micha, Thibaut Eguether, Abigail O. Smith, Nicole N. van der Wel, Matias Wagner, Lara Strittmatter, Philip L. Beales, Julie A. Jonassen, Isabelle Thiffault, Maxime Cadieux-Dion, Laura Boyes, Saba Sharif, Beyhan Tüysüz, Desiree Dunstheimer, Hans W. M. Niessen, William Devine, Cecilia W. Lo, Hannah M. Mitchison, Miriam Schmidts, Gregory J. Pazour

PLOS Genetics: published June 14, 2023 | https://doi.org/10.1371/journal.pgen.1010796

Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies

Shotaro Nakano, Soshiro Kashio, Kei Nishimura, Asuka Takeishi, Hina Kosakamoto, Fumiaki Obata, Erina Kuranaga, Takahiro Chihara, Yoshio Yamauchi, Toshiaki Isobe, Masayuki Miura

PLOS Genetics: published June 15, 2023 | https://doi.org/10.1371/journal.pgen.1010761

Genomic conservation of crop wild relatives: A case study of citrus

Nan Wang, Shuo Cao, Zhongjie Liu, Hua Xiao, Jianbing Hu, Xiaodong Xu, Peng Chen, Zhiyao Ma, Junli Ye, Lijun Chai, Wenwu Guo, Robert M. Larkin, Qiang Xu, Peter L. Morrell, Yongfeng Zhou, Xiuxin Deng

PLOS Genetics: published June 20, 2023 | https://doi.org/10.1371/journal.pgen.1010811

During heat stress in Myxococcus xanthus, the CdbS PilZ domain protein, in concert with two PilZ-DnaK chaperones, perturbs chromosome organization and accelerates cell death

Michael Seidel, Dorota Skotnicka, Timo Glatter, Lotte Søgaard-Andersen

PLOS Genetics: published June 20, 2023 | https://doi.org/10.1371/journal.pgen.1010819

Integrated analysis of genome-wide association studies and 3D epigenomic characteristics reveal the BMP2 gene regulating loin muscle depth in Yorkshire pigs

Yuanxin Miao, Yunxia Zhao, Siqi Wan, Quanshun Mei, Heng Wang, Chuanke Fu, Xinyun Li, Shuhong Zhao, Xuewen Xu, Tao Xiang

PLOS Genetics: published June 20, 2023 | https://doi.org/10.1371/journal.pgen.1010820

Regulatory logic of endogenous RNAi in silencing de novo genomic conflicts

Jeffrey Vedanayagam, Ching-Jung Lin, Ranjith Papareddy, Michael Nodine, Alex S. Flynt, Jiayu Wen, Eric C. Lai

PLOS Genetics: published June 21, 2023 | https://doi.org/10.1371/journal.pgen.1010787

Genetic basis of I-complex plasmid stability and conjugation

Zheng Jie Lian, Minh-Duy Phan, Steven J. Hancock, Nguyen Thi Khanh Nhu, David L. Paterson, Mark A. Schembri

PLOS Genetics: published June 22, 2023 | https://doi.org/10.1371/journal.pgen.1010773

Genetic analysis of a phenotypic loss in the mechanosensory entrainment of a circalunar clock

Dušica Briševac, Celine Prakash, Tobias S. Kaiser

PLOS Genetics: published June 22, 2023 | https://doi.org/10.1371/journal.pgen.1010763

Metabolic adaptation to consume butyrate under prolonged resource exhaustion

Sophia Katz, Claudia Grajeda-Iglesias, Bella Agranovich, Alia Ghrayeb, Ifat Abramovich, Sabrin Hilau, Eyal Gottlieb, Ruth Hershberg

PLOS Genetics: published June 22, 2023 | https://doi.org/10.1371/journal.pgen.1010812

Autosomal recessive hyposegmentation of granulocytes in Australian Shepherd Dogs indicates a role for LMBR1L in myeloid leukocytes

Bianca Lourdes Frehner, Matthias Christen, Iris M. Reichler, Vidhya Jagannathan, Marilisa Novacco, Barbara Riond, Laureen M. Peters, José Suárez Sánchez-Andrade, Aldona Pieńkowska-Schelling, Claude Schelling, Anja Kipar, Tosso Leeb, Orsolya Balogh

PLOS Genetics: published June 22, 2023 | https://doi.org/10.1371/journal.pgen.1010805

Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes

Eric Van Buren, Giorgia Radicioni, Sarah Lester, Wanda K. O’Neal, Hong Dang, Silva Kasela, Suresh Garudadri, Jeffrey L. Curtis, MeiLan K. Han, Jerry A. Krishnan, Emily S. Wan, Edwin K. Silverman, Annette Hastie, Victor E. Ortega, Tuuli Lappalainen, Martijn C. Nawijn, Maarten van den Berge, Stephanie A. Christenson, Yun Li, Michael H. Cho, Mehmet Kesimer, Samir N. P. Kelada

PLOS Genetics: published June 23, 2023 | https://doi.org/10.1371/journal.pgen.1010445

Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells

Aashika Sekar, Aaron Leiblich, S. Mark Wainwright, Cláudia C. Mendes, Dhruv Sarma, Josephine E. E. U. Hellberg, Carina Gandy, Deborah C. I. Goberdhan, Freddie C. Hamdy, Clive Wilson

PLOS Genetics: published June 26, 2023 | https://doi.org/10.1371/journal.pgen.1010815

The chloride antiporter CLCN7 is a modifier of lysosome dysfunction in FIG4 and VAC14 mutants

Xu Cao, Guy M. Lenk, Vedrana Mikusevic, Joseph A. Mindell, Miriam H. Meisler

PLOS Genetics: published June 26, 2023 | https://doi.org/10.1371/journal.pgen.1010800

A STIM dependent dopamine-neuropeptide axis maintains the larval drive to feed and grow in Drosophila

Nandashree Kasturacharya, Jasmine Kaur Dhall, Gaiti Hasan

PLOS Genetics: published June 26, 2023 | https://doi.org/10.1371/journal.pgen.1010435

The CERV protein of Cer1, a C. elegans LTR retrotransposon, is required for nuclear export of viral genomic RNA and can form giant nuclear rods

Bing Sun, Haram Kim, Craig C. Mello, James R. Priess

PLOS Genetics: published June 29, 2023 | https://doi.org/10.1371/journal.pgen.1010804

G3’M_TMD3 in the insect GABA receptor subunit, RDL, confers resistance to broflanilide and fluralaner

Yichi Zhang, Qiutang Huang, Chengwang Sheng, Genyan Liu, Kexin Zhang, Zhongqiang Jia, Tao Tang, Xin Mao, Andrew K. Jones, Zhaojun Han, Chunqing Zhao

PLOS Genetics: published June 29, 2023 | https://doi.org/10.1371/journal.pgen.1010814

Partial sequence identity in a 25-nucleotide long element is sufficient for transcriptional adaptation in the Caenorhabditis elegans act-5/act-3 model

Jordan M. Welker, Vahan Serobyan, Elhamalsadat Zaker Esfahani, Didier Y. R. Stainier

PLOS Genetics: published June 29, 2023 | https://doi.org/10.1371/journal.pgen.1010806

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