November 2017

Artist impression of localised lactation failure restricted to a mammary ductal branch while the remaining breast continues to lactate. Here, Oakes et al. show that mutation of Oas2 activated viral sensing within murine mammary glands and resulted in decreased milk protein synthesis, loss of proliferation, increased apoptosis and a robust interferon response. Activation of the Oas2 pathway could provide an evolutionary conserved mechanism to prevent viral transmission via milk. See Oakes et al.

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Image Credit: Dr. Samantha R. Oakes. Pencil on paper.

Viewpoints

Reimagining pheromone signalling in the model nematode Caenorhabditis elegans

Mark Viney, Simon Harvey

PLOS Genetics: published November 2, 2017 | https://doi.org/10.1371/journal.pgen.1007046

Perspective

CNGCs break through—A rice cyclic nucleotide-gated channel paves the way for pollen tube growth

Wolfgang Moeder, Keiko Yoshioka

PLOS Genetics: published November 30, 2017 | https://doi.org/10.1371/journal.pgen.1007066

Review

The evolution and adaptation of A-to-I RNA editing

Arielle L. Yablonovitch, Patricia Deng, Dionna Jacobson, Jin Billy Li

PLOS Genetics: published November 28, 2017 | https://doi.org/10.1371/journal.pgen.1007064

Research Articles

A case-control collapsing analysis identifies epilepsy genes implicated in trio sequencing studies focused on de novo mutations

Xiaolin Zhu, Raghavendra Padmanabhan, Brett Copeland, Joshua Bridgers, Zhong Ren, Sitharthan Kamalakaran, Ailbhe O'Driscoll-Collins, Samuel F. Berkovic, Ingrid E. Scheffer, Annapurna Poduri, Davide Mei, Renzo Guerrini, Daniel H. Lowenstein, Andrew S. Allen, Erin L. Heinzen, David B. Goldstein

PLOS Genetics: published November 29, 2017 | https://doi.org/10.1371/journal.pgen.1007104

Rv0004 is a new essential member of the mycobacterial DNA replication machinery

Katherine M. Mann, Deborah L. Huang, Anna J. Hooppaw, Michelle M. Logsdon, Kirill Richardson, Hark Joon Lee, Jacqueline M. Kimmey, Bree B. Aldridge, Christina L. Stallings

PLOS Genetics: published November 27, 2017 | https://doi.org/10.1371/journal.pgen.1007115

PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex

Ci Fu, Joseph Heitman

PLOS Genetics: published November 27, 2017 | https://doi.org/10.1371/journal.pgen.1007113

Epithelial rotation is preceded by planar symmetry breaking of actomyosin and protects epithelial tissue from cell deformations

Ivana Viktorinová, Ian Henry, Pavel Tomancak

PLOS Genetics: published November 27, 2017 | https://doi.org/10.1371/journal.pgen.1007107

Flip/flop mating-type switching in the methylotrophic yeast Ogataea polymorpha is regulated by an Efg1-Rme1-Ste12 pathway

Sara J. Hanson, Kevin P. Byrne, Kenneth H. Wolfe

PLOS Genetics: published November 27, 2017 | https://doi.org/10.1371/journal.pgen.1007092

Comprehensive molecular profiling of 718 Multiple Myelomas reveals significant differences in mutation frequencies between African and European descent cases

Zarko Manojlovic, Austin Christofferson, Winnie S. Liang, Jessica Aldrich, Megan Washington, Shukmei Wong, Daniel Rohrer, Scott Jewell, Rick A. Kittles, Mary Derome, Daniel Auclair, David Wesley Craig, Jonathan Keats, John D. Carpten

PLOS Genetics: published November 22, 2017 | https://doi.org/10.1371/journal.pgen.1007087

How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects

Christopher H. Chandler, Sudarshan Chari, Alycia Kowalski, Lin Choi, David Tack, Michael DeNieu, William Pitchers, Anne Sonnenschein, Leslie Marvin, Kristen Hummel, Christian Marier, Andrew Victory, Cody Porter, Anna Mammel, Julie Holms, Gayatri Sivaratnam, Ian Dworkin

PLOS Genetics: published November 22, 2017 | https://doi.org/10.1371/journal.pgen.1007075

mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay

Jennifer L. Anderson, Timothy S. Mulligan, Meng-Chieh Shen, Hui Wang, Catherine M. Scahill, Frederick J. Tan, Shao J. Du, Elisabeth M. Busch-Nentwich, Steven A. Farber

PLOS Genetics: published November 21, 2017 | https://doi.org/10.1371/journal.pgen.1007105

The nucleoid as a scaffold for the assembly of bacterial signaling complexes

Audrey Moine, Leon Espinosa, Eugenie Martineau, Mutum Yaikhomba, P. J. Jazleena, Deborah Byrne, Emanuele G. Biondi, Eugenio Notomista, Matteo Brilli, Virginie Molle, Pananghat Gayathri, Tâm Mignot, Emilia M. F. Mauriello

PLOS Genetics: published November 21, 2017 | https://doi.org/10.1371/journal.pgen.1007103

SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells

Sabine Jägle, Hauke Busch, Vivien Freihen, Sven Beyes, Monika Schrempp, Melanie Boerries, Andreas Hecht

PLOS Genetics: published November 20, 2017 | https://doi.org/10.1371/journal.pgen.1007109

Role of co-repressor genomic landscapes in shaping the Notch response

Stephen K. K. Chan, Gustavo Cerda-Moya, Robert Stojnic, Kat Millen, Bettina Fischer, Silvie Fexova, Lenka Skalska, Maria Gomez-Lamarca, Zoe Pillidge, Steven Russell, Sarah J. Bray

PLOS Genetics: published November 20, 2017 | https://doi.org/10.1371/journal.pgen.1007096

Post-guidance signaling by extracellular matrix-associated Slit/Slit-N maintains fasciculation and position of axon tracts in the nerve cord

Krishna Moorthi Bhat

PLOS Genetics: published November 20, 2017 | https://doi.org/10.1371/journal.pgen.1007094

Regulation of transcription elongation in response to osmostress

Andrea Silva, Santiago Cavero, Victoria Begley, Carme Solé, René Böttcher, Sebastián Chávez, Francesc Posas, Eulàlia de Nadal

PLOS Genetics: published November 20, 2017 | https://doi.org/10.1371/journal.pgen.1007090

Orienting the causal relationship between imprecisely measured traits using GWAS summary data

Gibran Hemani, Kate Tilling, George Davey Smith

PLOS Genetics: published November 17, 2017 | https://doi.org/10.1371/journal.pgen.1007081

UNC-16/JIP3 regulates early events in synaptic vesicle protein trafficking via LRK-1/LRRK2 and AP complexes

Bikash Choudhary, Madhushree Kamak, Neena Ratnakaran, Jitendra Kumar, Anjali Awasthi, Chun Li, Ken Nguyen, Kunihiro Matsumoto, Naoki Hisamoto, Sandhya P. Koushika

PLOS Genetics: published November 16, 2017 | https://doi.org/10.1371/journal.pgen.1007100

Natural variation of a sensor kinase controlling a conserved stress response pathway in Escherichia coli

Manuela Roggiani, Srujana S. Yadavalli, Mark Goulian

PLOS Genetics: published November 15, 2017 | https://doi.org/10.1371/journal.pgen.1007101

Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse

Jessica E. M. Dunleavy, Hidenobu Okuda, Anne E. O’Connor, D. Jo Merriner, Liza O’Donnell, Duangporn Jamsai, Martin Bergmann, Moira K. O’Bryan

PLOS Genetics: published November 14, 2017 | https://doi.org/10.1371/journal.pgen.1007078

The karrikin receptor KAI2 promotes drought resistance in Arabidopsis thaliana

Weiqiang Li, Kien Huu Nguyen, Ha Duc Chu, Chien Van Ha, Yasuko Watanabe, Yuriko Osakabe, Marco Antonio Leyva-González, Mayuko Sato, Kiminori Toyooka, Laura Voges, Maho Tanaka, Mohammad Golam Mostofa, Motoaki Seki, Mitsunori Seo, Shinjiro Yamaguchi, David C. Nelson, Chunjie Tian, Luis Herrera-Estrella, Lam-Son Phan Tran

PLOS Genetics: published November 13, 2017 | https://doi.org/10.1371/journal.pgen.1007076

A subset of sweet-sensing neurons identified by IR56d are necessary and sufficient for fatty acid taste

John M. Tauber, Elizabeth B. Brown, Yuanyuan Li, Maria E. Yurgel, Pavel Masek, Alex C. Keene

PLOS Genetics: published November 9, 2017 | https://doi.org/10.1371/journal.pgen.1007059

The combinatorial control of alternative splicing in C. elegans

June H. Tan, Andrew G. Fraser

PLOS Genetics: published November 9, 2017 | https://doi.org/10.1371/journal.pgen.1007033

A mutation in the viral sensor 2’-5’-oligoadenylate synthetase 2 causes failure of lactation

Samantha R. Oakes, David Gallego-Ortega, Prudence M. Stanford, Simon Junankar, Wendy Wing Yee Au, Zoya Kikhtyak, Anita von Korff, Claudio M. Sergio, Andrew M. K. Law, Lesley E. Castillo, Stephanie L. Allerdice, Adelaide I. J. Young, Catherine Piggin, Belinda Whittle, Edward Bertram, Matthew J. Naylor, Daniel L. Roden, Jesse Donovan, Alexei Korennykh, Christopher C. Goodnow, Moira K. O’Bryan, Christopher J. Ormandy

PLOS Genetics: published November 8, 2017 | https://doi.org/10.1371/journal.pgen.1007072

Hippo, TGF-β, and Src-MAPK pathways regulate transcription of the upd3 cytokine in Drosophila enterocytes upon bacterial infection

Philip Houtz, Alessandro Bonfini, Xi Liu, Jonathan Revah, Aurélien Guillou, Mickael Poidevin, Korneel Hens, Hsin-Yi Huang, Bart Deplancke, Yu-Chen Tsai, Nicolas Buchon

PLOS Genetics: published November 6, 2017 | https://doi.org/10.1371/journal.pgen.1007091

Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells

Minseung Choi, Diane P. Genereux, Jamie Goodson, Haneen Al-Azzawi, Shannon Q. Allain, Noah Simon, Stan Palasek, Carol B. Ware, Chris Cavanaugh, Daniel G. Miller, Winslow C. Johnson, Kevin D. Sinclair, Reinhard Stöger, Charles D. Laird

PLOS Genetics: published November 6, 2017 | https://doi.org/10.1371/journal.pgen.1007060

Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor

Charly Abi Ghanem, Cindy Degerny, Rashad Hussain, Philippe Liere, Antoine Pianos, Sophie Tourpin, René Habert, Wendy B. Macklin, Michael Schumacher, Abdel M. Ghoumari

PLOS Genetics: published November 6, 2017 | https://doi.org/10.1371/journal.pgen.1007049

How convincing is a matching Y-chromosome profile?

Mikkel M. Andersen, David J. Balding

PLOS Genetics: published November 3, 2017 | https://doi.org/10.1371/journal.pgen.1007028

Co-option of the bZIP transcription factor Vrille as the activator of Doublesex1 in environmental sex determination of the crustacean Daphnia magna

Nur Syafiqah Mohamad Ishak, Quang Dang Nong, Tomoaki Matsuura, Yasuhiko Kato, Hajime Watanabe

PLOS Genetics: published November 2, 2017 | https://doi.org/10.1371/journal.pgen.1006953

Loss of the Caenorhabditis elegans pocket protein LIN-35 reveals MuvB's innate function as the repressor of DREAM target genes

Paul D. Goetsch, Jacob M. Garrigues, Susan Strome

PLOS Genetics: published November 1, 2017 | https://doi.org/10.1371/journal.pgen.1007088

Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease

Maria Victoria Fernández, Jong Hun Kim, John P. Budde, Kathleen Black, Alexandra Medvedeva, Ben Saef, Yuetiva Deming, Jorge Del-Aguila, Laura Ibañez, Umber Dube, Oscar Harari, Joanne Norton, Rachel Chasse, John C. Morris, Alison Goate, NIA-LOAD family study group, NCRAD, Carlos Cruchaga

PLOS Genetics: published November 1, 2017 | https://doi.org/10.1371/journal.pgen.1007045

Cover

Oas2 activation results in lactation failure.

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