July 2017

Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport

Daniel J. Barbosa, Joana Duro, Bram Prevo, Dhanya K. Cheerambathur, Ana X. Carvalho, Reto Gassmann

PLOS Genetics: published July 31, 2017 | https://doi.org/10.1371/journal.pgen.1006941

Modular function of long noncoding RNA, COLDAIR, in the vernalization response

Dong-Hwan Kim, Yanpeng Xi, Sibum Sung

PLOS Genetics: published July 31, 2017 | https://doi.org/10.1371/journal.pgen.1006939

The Drosophila Duox maturation factor is a key component of a positive feedback loop that sustains regeneration signaling

Sumbul Jawed Khan, Syeda Nayab Fatima Abidi, Andrea Skinner, Yuan Tian, Rachel K. Smith-Bolton

PLOS Genetics: published July 28, 2017 | https://doi.org/10.1371/journal.pgen.1006937

Nuclear/cytoplasmic transport defects in BBS6 underlie congenital heart disease through perturbation of a chromatin remodeling protein

Charles Anthony Scott, Autumn N. Marsden, Michael R. Rebagliati, Qihong Zhang, Xitiz Chamling, Charles C. Searby, Lisa M. Baye, Val C. Sheffield, Diane C. Slusarski

PLOS Genetics: published July 28, 2017 | https://doi.org/10.1371/journal.pgen.1006936

The RhoJ-BAD signaling network: An Achilles’ heel for BRAF mutant melanomas

Rolando Ruiz, Sohail Jahid, Melissa Harris, Diego M. Marzese, Francisco Espitia, Priya Vasudeva, Chi-Fen Chen, Sebastien de Feraudy, Jie Wu, Daniel L. Gillen, Tatiana B. Krasieva, Bruce J. Tromberg, William J. Pavan, Dave S. Hoon, Anand K. Ganesan

PLOS Genetics: published July 28, 2017 | https://doi.org/10.1371/journal.pgen.1006913

The mecillinam resistome reveals a role for peptidoglycan endopeptidases in stimulating cell wall synthesis in Escherichia coli

Ghee Chuan Lai, Hongbaek Cho, Thomas G. Bernhardt

PLOS Genetics: published July 27, 2017 | https://doi.org/10.1371/journal.pgen.1006934

Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice

Kota Inoue, Kenji Ichiyanagi, Kei Fukuda, Michael Glinka, Hiroyuki Sasaki

PLOS Genetics: published July 27, 2017 | https://doi.org/10.1371/journal.pgen.1006926

Krox20 hindbrain regulation incorporates multiple modes of cooperation between cis-acting elements

Elodie Thierion, Johan Le Men, Samuel Collombet, Céline Hernandez, Fanny Coulpier, Patrick Torbey, Morgane Thomas-Chollier, Daan Noordermeer, Patrick Charnay, Pascale Gilardi-Hebenstreit

PLOS Genetics: published July 27, 2017 | https://doi.org/10.1371/journal.pgen.1006903

Replication stress affects the fidelity of nucleosome-mediated epigenetic inheritance

Wenzhu Li, Jia Yi, Pamela Agbu, Zheng Zhou, Richard L. Kelley, Scott Kallgren, Songtao Jia, Xiangwei He

PLOS Genetics: published July 27, 2017 | https://doi.org/10.1371/journal.pgen.1006900

MiR-1254 suppresses HO-1 expression through seed region-dependent silencing and non-seed interaction with TFAP2A transcript to attenuate NSCLC growth

Mengfan Pu, Chenggang Li, Xinming Qi, Jing Chen, Yizheng Wang, Lulu Gao, Lingling Miao, Jin Ren

PLOS Genetics: published July 27, 2017 | https://doi.org/10.1371/journal.pgen.1006896

The population genomics of archaeological transition in west Iberia: Investigation of ancient substructure using imputation and haplotype-based methods

Rui Martiniano, Lara M. Cassidy, Ros Ó'Maoldúin, Russell McLaughlin, Nuno M. Silva, Licinio Manco, Daniel Fidalgo, Tania Pereira, Maria J. Coelho, Miguel Serra, Joachim Burger, Rui Parreira, Elena Moran, Antonio C. Valera, Eduardo Porfirio, Rui Boaventura, Ana M. Silva, Daniel G. Bradley

PLOS Genetics: published July 27, 2017 | https://doi.org/10.1371/journal.pgen.1006852

Dynamic hyper-editing underlies temperature adaptation in Drosophila

Ilana Buchumenski, Osnat Bartok, Reut Ashwal-Fluss, Varun Pandey, Hagit T. Porath, Erez Y. Levanon, Sebastian Kadener

PLOS Genetics: published July 26, 2017 | https://doi.org/10.1371/journal.pgen.1006931

Reduced dosage of the chromosome axis factor Red1 selectively disrupts the meiotic recombination checkpoint in Saccharomyces cerevisiae

Tovah E. Markowitz, Daniel Suarez, Hannah G. Blitzblau, Neem J. Patel, Andrew L. Markhard, Amy J. MacQueen, Andreas Hochwagen

PLOS Genetics: published July 26, 2017 | https://doi.org/10.1371/journal.pgen.1006928

Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits

Lorin Crawford, Ping Zeng, Sayan Mukherjee, Xiang Zhou

PLOS Genetics: published July 26, 2017 | https://doi.org/10.1371/journal.pgen.1006869

Control of RUNX-induced repression of Notch signaling by MLF and its partner DnaJ-1 during Drosophila hematopoiesis

Marion Miller, Aichun Chen, Vanessa Gobert, Benoit Augé, Mathilde Beau, Odile Burlet-Schiltz, Marc Haenlin, Lucas Waltzer

PLOS Genetics: published July 25, 2017 | https://doi.org/10.1371/journal.pgen.1006932

Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer’s disease

Qiongshi Lu, Ryan L. Powles, Sarah Abdallah, Derek Ou, Qian Wang, Yiming Hu, Yisi Lu, Wei Liu, Boyang Li, Shubhabrata Mukherjee, Paul K. Crane, Hongyu Zhao

PLOS Genetics: published July 24, 2017 | https://doi.org/10.1371/journal.pgen.1006933

Clinically severe CACNA1A alleles affect synaptic function and neurodegeneration differentially

Xi Luo, Jill A. Rosenfeld, Shinya Yamamoto, Tamar Harel, Zhongyuan Zuo, Melissa Hall, Klaas J. Wierenga, Matthew T. Pastore, Dennis Bartholomew, Mauricio R. Delgado, Joshua Rotenberg, Richard Alan Lewis, Lisa Emrick, Carlos A. Bacino, Mohammad K. Eldomery, Zeynep Coban Akdemir, Fan Xia, Yaping Yang, Seema R. Lalani, Timothy Lotze, James R. Lupski, Brendan Lee, Hugo J. Bellen, Michael F. Wangler, Members of the UDN

PLOS Genetics: published July 24, 2017 | https://doi.org/10.1371/journal.pgen.1006905

T-DNA-genome junctions form early after infection and are influenced by the chromatin state of the host genome

Shay Shilo, Pooja Tripathi, Cathy Melamed-Bessudo, Oren Tzfadia, Theodore R. Muth, Avraham A. Levy

PLOS Genetics: published July 24, 2017 | https://doi.org/10.1371/journal.pgen.1006875

Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function

Joshua W. Vincentz, Kevin P. Toolan, Wenjun Zhang, Anthony B. Firulli

PLOS Genetics: published July 21, 2017 | https://doi.org/10.1371/journal.pgen.1006922

Mutations in the Caenorhabditis elegans orthologs of human genes required for mitochondrial tRNA modification cause similar electron transport chain defects but different nuclear responses

Carmen Navarro-González, Ismaïl Moukadiri, Magda Villarroya, Ernesto López-Pascual, Simon Tuck, M.-Eugenia Armengod

PLOS Genetics: published July 21, 2017 | https://doi.org/10.1371/journal.pgen.1006921

A Drosophila model for toxicogenomics: Genetic variation in susceptibility to heavy metal exposure

Shanshan Zhou, Sarah E. Luoma, Genevieve E. St. Armour, Esha Thakkar, Trudy F. C. Mackay, Robert R. H. Anholt

PLOS Genetics: published July 21, 2017 | https://doi.org/10.1371/journal.pgen.1006907

Filamin actin-binding and titin-binding fulfill distinct functions in Z-disc cohesion

Nicanor González-Morales, Tristan K. Holenka, Frieder Schöck

PLOS Genetics: published July 21, 2017 | https://doi.org/10.1371/journal.pgen.1006880

Use of a microfluidic platform to uncover basic features of energy and environmental stress responses in individual cells of Bacillus subtilis

Matthew T. Cabeen, Jonathan R. Russell, Johan Paulsson, Richard Losick

PLOS Genetics: published July 20, 2017 | https://doi.org/10.1371/journal.pgen.1006901

Germline and reproductive tract effects intensify in male mice with successive generations of estrogenic exposure

Tegan S. Horan, Alyssa Marre, Terry Hassold, Crystal Lawson, Patricia A. Hunt

PLOS Genetics: published July 20, 2017 | https://doi.org/10.1371/journal.pgen.1006885

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

Jackson Champer, Riona Reeves, Suh Yeon Oh, Chen Liu, Jingxian Liu, Andrew G. Clark, Philipp W. Messer

PLOS Genetics: published July 20, 2017 | https://doi.org/10.1371/journal.pgen.1006796

Persistent damaged bases in DNA allow mutagenic break repair in Escherichia coli

Jessica M. Moore, Raul Correa, Susan M. Rosenberg, P. J. Hastings

PLOS Genetics: published July 20, 2017 | https://doi.org/10.1371/journal.pgen.1006733

Termination factor Rho: From the control of pervasive transcription to cell fate determination in Bacillus subtilis

Vladimir Bidnenko, Pierre Nicolas, Aleksandra Grylak-Mielnicka, Olivier Delumeau, Sandrine Auger, Anne Aucouturier, Cyprien Guerin, Francis Repoila, Jacek Bardowski, Stéphane Aymerich, Elena Bidnenko

PLOS Genetics: published July 19, 2017 | https://doi.org/10.1371/journal.pgen.1006909

The nucleoid occlusion factor Noc controls DNA replication initiation in Staphylococcus aureus

Ting Pang, Xindan Wang, Hoong Chuin Lim, Thomas G. Bernhardt, David Z. Rudner

PLOS Genetics: published July 19, 2017 | https://doi.org/10.1371/journal.pgen.1006908

Kinesin-1 promotes chondrocyte maintenance during skeletal morphogenesis

Adrian Santos-Ledo, Marina Garcia-Macia, Philip D. Campbell, Marta Gronska, Florence L. Marlow

PLOS Genetics: published July 17, 2017 | https://doi.org/10.1371/journal.pgen.1006918

Statistical correction of the Winner’s Curse explains replication variability in quantitative trait genome-wide association studies

Cameron Palmer, Itsik Pe’er

PLOS Genetics: published July 17, 2017 | https://doi.org/10.1371/journal.pgen.1006916

Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid

Maha El Shahawy, Claes-Göran Reibring, Cynthia L. Neben, Kristina Hallberg, Pauline Marangoni, Brian D. Harfe, Ophir D. Klein, Anders Linde, Amel Gritli-Linde

PLOS Genetics: published July 17, 2017 | https://doi.org/10.1371/journal.pgen.1006914

A Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes

Guolun Wang, Lisa Gutzwiller, David Li-Kroeger, Brian Gebelein

PLOS Genetics: published July 17, 2017 | https://doi.org/10.1371/journal.pgen.1006910

A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription

Chelsea Herdman, Jean-Clement Mars, Victor Y. Stefanovsky, Michel G. Tremblay, Marianne Sabourin-Felix, Helen Lindsay, Mark D. Robinson, Tom Moss

PLOS Genetics: published July 17, 2017 | https://doi.org/10.1371/journal.pgen.1006899

The T-cell leukemia related rpl10-R98S mutant traps the 60S export adapter Nmd3 in the ribosomal P site in yeast

Stephanie Patchett, Sharmishtha Musalgaonkar, Andrey G. Malyutin, Arlen W. Johnson

PLOS Genetics: published July 17, 2017 | https://doi.org/10.1371/journal.pgen.1006894

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway

Steffen Grampp, Virginia Schmid, Rafik Salama, Victoria Lauer, Franziska Kranz, James L. Platt, James Smythies, Hani Choudhry, Margarete Goppelt-Struebe, Peter J. Ratcliffe, David R. Mole, Johannes Schödel

PLOS Genetics: published July 17, 2017 | https://doi.org/10.1371/journal.pgen.1006872

African genetic ancestry interacts with body mass index to modify risk for uterine fibroids

Ayush Giri, Todd L. Edwards, Katherine E. Hartmann, Eric S. Torstenson, Melissa Wellons, Pamela J. Schreiner, Digna R. Velez Edwards

PLOS Genetics: published July 17, 2017 | https://doi.org/10.1371/journal.pgen.1006871

Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis

Paula Dietrich, Irudayam Maria Johnson, Shanta Alli, Ioannis Dragatsis

PLOS Genetics: published July 17, 2017 | https://doi.org/10.1371/journal.pgen.1006846

OsCNGC13 promotes seed-setting rate by facilitating pollen tube growth in stylar tissues

Yang Xu, Jie Yang, Yihua Wang, Jiachang Wang, Yang Yu, Yu Long, Yunlong Wang, Huan Zhang, Yulong Ren, Jun Chen, Ying Wang, Xin Zhang, Xiuping Guo, Fuqing Wu, Shanshan Zhu, Qibing Lin, Ling Jiang, Chuanyin Wu, Haiyang Wang, Jianmin Wan

PLOS Genetics: published July 14, 2017 | https://doi.org/10.1371/journal.pgen.1006906

Tex19.1 promotes Spo11-dependent meiotic recombination in mouse spermatocytes

James H. Crichton, Christopher J. Playfoot, Marie MacLennan, David Read, Howard J. Cooke, Ian R. Adams

PLOS Genetics: published July 14, 2017 | https://doi.org/10.1371/journal.pgen.1006904

Notch-dependent epithelial fold determines boundary formation between developmental fields in the Drosophila antenna

Hui-Yu Ku, Y. Henry Sun

PLOS Genetics: published July 14, 2017 | https://doi.org/10.1371/journal.pgen.1006898

NlpD links cell wall remodeling and outer membrane invagination during cytokinesis in Escherichia coli

Mary-Jane Tsang, Anastasiya A. Yakhnina, Thomas G. Bernhardt

PLOS Genetics: published July 14, 2017 | https://doi.org/10.1371/journal.pgen.1006888

An ancient neurotrophin receptor code; a single Runx/Cbfβ complex determines somatosensory neuron fate specification in zebrafish

Philia Gau, Andrew Curtright, Logan Condon, David W. Raible, Ajay Dhaka

PLOS Genetics: published July 14, 2017 | https://doi.org/10.1371/journal.pgen.1006884

Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing

Ai Tian, Hassina Benchabane, Zhenghan Wang, Chloe Zimmerman, Nan Xin, Jessica Perochon, Gabriela Kalna, Owen J. Sansom, Chao Cheng, Julia B. Cordero, Yashi Ahmed

PLOS Genetics: published July 14, 2017 | https://doi.org/10.1371/journal.pgen.1006870

The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis

Jeffrey L. Kurkewich, Justin Hansen, Nathan Klopfenstein, Helen Zhang, Christian Wood, Austin Boucher, Joseph Hickman, David E. Muench, H. Leighton Grimes, Richard Dahl

PLOS Genetics: published July 13, 2017 | https://doi.org/10.1371/journal.pgen.1006887

Mouse models of 17q21.31 microdeletion and microduplication syndromes highlight the importance of Kansl1 for cognition

Thomas Arbogast, Giovanni Iacono, Claire Chevalier, Nurudeen O. Afinowi, Xander Houbaert, Matthijs C. van Eede, Christine Laliberte, Marie-Christine Birling, Katrin Linda, Hamid Meziane, Mohammed Selloum, Tania Sorg, Nael Nadif Kasri, David A. Koolen, Henk G. Stunnenberg, R. Mark Henkelman, Maksym Kopanitsa, Yann Humeau, Bert B. A. De Vries, Yann Herault

PLOS Genetics: published July 13, 2017 | https://doi.org/10.1371/journal.pgen.1006886

The ancestral levels of transcription and the evolution of sexual phenotypes in filamentous fungi

Frances Trail, Zheng Wang, Kayla Stefanko, Caitlyn Cubba, Jeffrey P. Townsend

PLOS Genetics: published July 13, 2017 | https://doi.org/10.1371/journal.pgen.1006867

Temporal dynamics of neurogenomic plasticity in response to social interactions in male threespined sticklebacks

Syed Abbas Bukhari, Michael C. Saul, Christopher H. Seward, Huimin Zhang, Miles Bensky, Noelle James, Sihai Dave Zhao, Sriram Chandrasekaran, Lisa Stubbs, Alison M. Bell

PLOS Genetics: published July 13, 2017 | https://doi.org/10.1371/journal.pgen.1006840

Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons

Stefan Zdraljevic, Christine Strand, Hannah S. Seidel, Daniel E. Cook, John G. Doench, Erik C. Andersen

PLOS Genetics: published July 12, 2017 | https://doi.org/10.1371/journal.pgen.1006891

Systematic identification and characterization of regulatory elements derived from human endogenous retroviruses

Jumpei Ito, Ryota Sugimoto, Hirofumi Nakaoka, Shiro Yamada, Tetsuaki Kimura, Takahide Hayano, Ituro Inoue

PLOS Genetics: published July 12, 2017 | https://doi.org/10.1371/journal.pgen.1006883

Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis

Zhidan Xia, Jiayu Wei, Yingniang Li, Jia Wang, Wenwen Li, Kai Wang, Xiaoli Hong, Lu Zhao, Caiyong Chen, Junxia Min, Fudi Wang

PLOS Genetics: published July 10, 2017 | https://doi.org/10.1371/journal.pgen.1006892

Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage

Joakim Klar, Jörg Piontek, Susanne Milatz, Muhammad Tariq, Muhammad Jameel, Tilman Breiderhoff, Jens Schuster, Ambrin Fatima, Maria Asif, Muhammad Sher, Katrin Mäbert, Anja Fromm, Shahid M. Baig, Dorothee Günzel, Niklas Dahl

PLOS Genetics: published July 7, 2017 | https://doi.org/10.1371/journal.pgen.1006897

Xist RNA repeat E is essential for ASH2L recruitment to the inactive X and regulates histone modifications and escape gene expression

Minghui Yue, Akiyo Ogawa, Norishige Yamada, John Lalith Charles Richard, Artem Barski, Yuya Ogawa

PLOS Genetics: published July 7, 2017 | https://doi.org/10.1371/journal.pgen.1006890

Genetic control of the root system in rice under normal and drought stress conditions by genome-wide association study

Xiaokai Li, Zilong Guo, Yan Lv, Xiang Cen, Xipeng Ding, Hua Wu, Xianghua Li, Jianping Huang, Lizhong Xiong

PLOS Genetics: published July 7, 2017 | https://doi.org/10.1371/journal.pgen.1006889

Processing closely spaced lesions during Nucleotide Excision Repair triggers mutagenesis in E. coli

Régine Janel-Bintz, Rita L. Napolitano, Asako Isogawa, Shingo Fujii, Robert P. Fuchs

PLOS Genetics: published July 7, 2017 | https://doi.org/10.1371/journal.pgen.1006881

Yorkie is required to restrict the injury responses in planarians

Alexander Y. T. Lin, Bret J. Pearson

PLOS Genetics: published July 7, 2017 | https://doi.org/10.1371/journal.pgen.1006874

The nucleoid occlusion protein SlmA is a direct transcriptional activator of chitobiose utilization in Vibrio cholerae

Catherine A. Klancher, Chelsea A. Hayes, Ankur B. Dalia

PLOS Genetics: published July 6, 2017 | https://doi.org/10.1371/journal.pgen.1006877

EGFR controls Drosophila tracheal tube elongation by intracellular trafficking regulation

Ivette Olivares-Castiñeira, Marta Llimargas

PLOS Genetics: published July 5, 2017 | https://doi.org/10.1371/journal.pgen.1006882

Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation

Eunhee Kim, Kazuko Sakata, Francesca-Fang Liao

PLOS Genetics: published July 5, 2017 | https://doi.org/10.1371/journal.pgen.1006849

Stochasticity in the enterococcal sex pheromone response revealed by quantitative analysis of transcription in single cells

Rebecca J. Breuer, Arpan Bandyopadhyay, Sofie A. O’Brien, Aaron M. T. Barnes, Ryan C. Hunter, Wei-Shou Hu, Gary M. Dunny

PLOS Genetics: published July 3, 2017 | https://doi.org/10.1371/journal.pgen.1006878

Evolution and multiple roles of the Pancrustacea specific transcription factor zelda in insects

Lupis Ribeiro, Vitória Tobias-Santos, Daniele Santos, Felipe Antunes, Geórgia Feltran, Jackson de Souza Menezes, L. Aravind, Thiago M. Venancio, Rodrigo Nunes da Fonseca

PLOS Genetics: published July 3, 2017 | https://doi.org/10.1371/journal.pgen.1006868

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Late Neolithic Portuguese human remains studied using ancient genomics.

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