The Janus-faced Nature of miR-22 in Hematopoiesis: Is It an Oncogenic Tumor Suppressor or Rather a Tumor-Suppressive Oncogene?

Alexander Arthur Wurm, Daniel G. Tenen, Gerhard Behre

PLOS Genetics: published January 12, 2017 | https://doi.org/10.1371/journal.pgen.1006505

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Recruitment of Fkh1 to replication origins requires precisely positioned Fkh1/2 binding sites and concurrent assembly of the pre-replicative complex

Allan Reinapae, Kristiina Jalakas, Nikita Avvakumov, Marko Lõoke, Kersti Kristjuhan, Arnold Kristjuhan

PLOS Genetics: published January 31, 2017 | https://doi.org/10.1371/journal.pgen.1006588

β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans

Michael Walser, Christoph Alois Umbricht, Erika Fröhli, Paolo Nanni, Alex Hajnal

PLOS Genetics: published January 30, 2017 | https://doi.org/10.1371/journal.pgen.1006592

Re-wiring of energy metabolism promotes viability during hyperreplication stress in E. coli

Godefroid Charbon, Christopher Campion, Siu Hung Joshua Chan, Louise Bjørn, Allan Weimann, Luís Cláudio Nascimento da Silva, Peter Ruhdal Jensen, Anders Løbner-Olesen

PLOS Genetics: published January 27, 2017 | https://doi.org/10.1371/journal.pgen.1006590

High-Throughput Characterization of Blood Serum Proteomics of IBD Patients with Respect to Aging and Genetic Factors

Antonio F. Di Narzo, Shannon E. Telesco, Carrie Brodmerkel, Carmen Argmann, Lauren A. Peters, Katherine Li, Brian Kidd, Joel Dudley, Judy Cho, Eric E. Schadt, Andrew Kasarskis, Radu Dobrin, Ke Hao

PLOS Genetics: published January 27, 2017 | https://doi.org/10.1371/journal.pgen.1006565

Nutrient-Dependent Endocycling in Steroidogenic Tissue Dictates Timing of Metamorphosis in Drosophila melanogaster

Yuya Ohhara, Satoru Kobayashi, Naoki Yamanaka

PLOS Genetics: published January 25, 2017 | https://doi.org/10.1371/journal.pgen.1006583

Post-Translational Dosage Compensation Buffers Genetic Perturbations to Stoichiometry of Protein Complexes

Koji Ishikawa, Koji Makanae, Shintaro Iwasaki, Nicholas T. Ingolia, Hisao Moriya

PLOS Genetics: published January 25, 2017 | https://doi.org/10.1371/journal.pgen.1006554

Genetic Variation in the Social Environment Contributes to Health and Disease

Amelie Baud, Megan K. Mulligan, Francesco Paolo Casale, Jesse F. Ingels, Casey J. Bohl, Jacques Callebert, Jean-Marie Launay, Jon Krohn, Andres Legarra, Robert W. Williams, Oliver Stegle

PLOS Genetics: published January 25, 2017 | https://doi.org/10.1371/journal.pgen.1006498

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The Replisomes Remain Spatially Proximal throughout the Cell Cycle in Bacteria

Sarah M. Mangiameli, Brian T. Veit, Houra Merrikh, Paul A. Wiggins

PLOS Genetics: published January 23, 2017 | https://doi.org/10.1371/journal.pgen.1006582

A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice

Bo Xiong, Yangu Zhao, Stephanie Beall, Anna Burkart Sadusky, Jurrien Dean

PLOS Genetics: published January 23, 2017 | https://doi.org/10.1371/journal.pgen.1006580

Reduced Insulin/Insulin-Like Growth Factor Receptor Signaling Mitigates Defective Dendrite Morphogenesis in Mutants of the ER Stress Sensor IRE-1

Yehuda Salzberg, Andrew J. Coleman, Kevin Celestrin, Moran Cohen-Berkman, Thomas Biederer, Sivan Henis-Korenblit, Hannes E. Bülow

PLOS Genetics: published January 23, 2017 | https://doi.org/10.1371/journal.pgen.1006579

Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction

Takashi Nakasuji, Narumi Ogonuki, Tomoki Chiba, Tomomi Kato, Kumiko Shiozawa, Kenji Yamatoya, Hiromitsu Tanaka, Tadashi Kondo, Kenji Miyado, Naoyuki Miyasaka, Toshiro Kubota, Atsuo Ogura, Hiroshi Asahara

PLOS Genetics: published January 23, 2017 | https://doi.org/10.1371/journal.pgen.1006578

A Gap Junction Protein, Inx2, Modulates Calcium Flux to Specify Border Cell Fate during Drosophila oogenesis

Aresh Sahu, Ritabrata Ghosh, Girish Deshpande, Mohit Prasad

PLOS Genetics: published January 23, 2017 | https://doi.org/10.1371/journal.pgen.1006542

Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint

Michał Dmowski, Justyna Rudzka, Judith L. Campbell, Piotr Jonczyk, Iwona J. Fijałkowska

PLOS Genetics: published January 20, 2017 | https://doi.org/10.1371/journal.pgen.1006572

Age-Dependent Neuroendocrine Signaling from Sensory Neurons Modulates the Effect of Dietary Restriction on Longevity of Caenorhabditis elegans

Marissa Fletcher, Dennis H. Kim

PLOS Genetics: published January 20, 2017 | https://doi.org/10.1371/journal.pgen.1006544

Bombyx mori P-element Somatic Inhibitor (BmPSI) Is a Key Auxiliary Factor for Silkworm Male Sex Determination

Jun Xu, Shuqing Chen, Baosheng Zeng, Anthony A. James, Anjiang Tan, Yongping Huang

PLOS Genetics: published January 19, 2017 | https://doi.org/10.1371/journal.pgen.1006576

A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets

Jaleal S. Sanjak, Anthony D. Long, Kevin R. Thornton

PLOS Genetics: published January 19, 2017 | https://doi.org/10.1371/journal.pgen.1006573

Anaerobically Grown Escherichia coli Has an Enhanced Mutation Rate and Distinct Mutational Spectra

Sonal Shewaramani, Thomas J. Finn, Sinead C. Leahy, Rees Kassen, Paul B. Rainey, Christina D. Moon

PLOS Genetics: published January 19, 2017 | https://doi.org/10.1371/journal.pgen.1006570

Genome-Wide Binding of Posterior HOXA/D Transcription Factors Reveals Subgrouping and Association with CTCF

Ivana Jerković, Daniel M. Ibrahim, Guillaume Andrey, Stefan Haas, Peter Hansen, Catrin Janetzki, Irene González Navarrete, Peter N. Robinson, Jochen Hecht, Stefan Mundlos

PLOS Genetics: published January 19, 2017 | https://doi.org/10.1371/journal.pgen.1006567

Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication

Nina Peel, Jyoti Iyer, Anar Naik, Michael P. Dougherty, Markus Decker, Kevin F. O’Connell

PLOS Genetics: published January 19, 2017 | https://doi.org/10.1371/journal.pgen.1006543

Rfx2 Stabilizes Foxj1 Binding at Chromatin Loops to Enable Multiciliated Cell Gene Expression

Ian K. Quigley, Chris Kintner

PLOS Genetics: published January 19, 2017 | https://doi.org/10.1371/journal.pgen.1006538

KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype

Petr Kasparek, Zuzana Ileninova, Olga Zbodakova, Ivan Kanchev, Oldrich Benada, Karel Chalupsky, Maria Brattsand, Inken M. Beck, Radislav Sedlacek

PLOS Genetics: published January 17, 2017 | https://doi.org/10.1371/journal.pgen.1006566

PRC2 Represses Hormone-Induced Somatic Embryogenesis in Vegetative Tissue of Arabidopsis thaliana

Iva Mozgová, Rafael Muñoz-Viana, Lars Hennig

PLOS Genetics: published January 17, 2017 | https://doi.org/10.1371/journal.pgen.1006562

Cardiomyocyte Regulation of Systemic Lipid Metabolism by the Apolipoprotein B-Containing Lipoproteins in Drosophila

Sunji Lee, Hong Bao, Zachary Ishikawa, Weidong Wang, Hui-Ying Lim

PLOS Genetics: published January 17, 2017 | https://doi.org/10.1371/journal.pgen.1006555

A Novel Imprinted Gene NUWA Controls Mitochondrial Function in Early Seed Development in Arabidopsis

Shan He, Yan Sun, Qian Yang, Xiangyu Zhang, Qingpei Huang, Peng Zhao, Mengxiang Sun, Jingjing Liu, Weiqiang Qian, Genji Qin, Hongya Gu, Li-Jia Qu

PLOS Genetics: published January 17, 2017 | https://doi.org/10.1371/journal.pgen.1006553

Inference of Candidate Germline Mutator Loci in Humans from Genome-Wide Haplotype Data

Cathal Seoighe, Aylwyn Scally

PLOS Genetics: published January 17, 2017 | https://doi.org/10.1371/journal.pgen.1006549

Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology

Kevin K. Ogden, Wenjuan Chen, Sharon A. Swanger, Miranda J. McDaniel, Linlin Z. Fan, Chun Hu, Anel Tankovic, Hirofumi Kusumoto, Gabrielle J. Kosobucki, Anthony J. Schulien, Zhuocheng Su, Joseph Pecha, Subhrajit Bhattacharya, Slavé Petrovski, Adam E. Cohen, Elias Aizenman, Stephen F. Traynelis, Hongjie Yuan

PLOS Genetics: published January 17, 2017 | https://doi.org/10.1371/journal.pgen.1006536

Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies

Ronald de Vlaming, Aysu Okbay, Cornelius A. Rietveld, Magnus Johannesson, Patrik K. E. Magnusson, André G. Uitterlinden, Frank J. A. van Rooij, Albert Hofman, Patrick J. F. Groenen, A. Roy Thurik, Philipp D. Koellinger

PLOS Genetics: published January 17, 2017 | https://doi.org/10.1371/journal.pgen.1006495

Inhibition of a NF-κB/Diap1 Pathway by PGRP-LF Is Required for Proper Apoptosis during Drosophila Development

Raphael Tavignot, Delphine Chaduli, Fatoumata Djitte, Bernard Charroux, Julien Royet

PLOS Genetics: published January 13, 2017 | https://doi.org/10.1371/journal.pgen.1006569

Acylation of the Type 3 Secretion System Translocon Using a Dedicated Acyl Carrier Protein

Julie P. Viala, Valérie Prima, Rémy Puppo, Rym Agrebi, Mickaël J. Canestrari, Sabrina Lignon, Nicolas Chauvin, Stéphane Méresse, Tâm Mignot, Régine Lebrun, Emmanuelle Bouveret

PLOS Genetics: published January 13, 2017 | https://doi.org/10.1371/journal.pgen.1006556

Anillin Phosphorylation Controls Timely Membrane Association and Successful Cytokinesis

Hyunjung Kim, James M. Johnson, Robert F. Lera, Sarang Brahma, Mark E. Burkard

PLOS Genetics: published January 12, 2017 | https://doi.org/10.1371/journal.pgen.1006511

Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice

Martina M. A. Muggenthaler, Biswajit Chowdhury, S. Naimul Hasan, Harold E. Cross, Brian Mark, Gaurav V. Harlalka, Michael A. Patton, Miho Ishida, Elijah R. Behr, Sanjay Sharma, Kenneth Zahka, Eissa Faqeih, Brian Blakley, Mike Jackson, Melissa Lees, Vernon Dolinsky, Leroy Cross, Philip Stanier, Claire Salter, Emma L. Baple, Fowzan S. Alkuraya, Andrew H. Crosby, Barbara Triggs-Raine, Barry A. Chioza

PLOS Genetics: published January 12, 2017 | https://doi.org/10.1371/journal.pgen.1006470

Mechanical Control of Whole Body Shape by a Single Cuticular Protein Obstructor-E in Drosophila melanogaster

Reiko Tajiri, Nobuhiro Ogawa, Haruhiko Fujiwara, Tetsuya Kojima

PLOS Genetics: published January 11, 2017 | https://doi.org/10.1371/journal.pgen.1006548

Reverse Pathway Genetic Approach Identifies Epistasis in Autism Spectrum Disorders

Ileena Mitra, Alinoë Lavillaureix, Erika Yeh, Michela Traglia, Kathryn Tsang, Carrie E. Bearden, Katherine A. Rauen, Lauren A. Weiss

PLOS Genetics: published January 11, 2017 | https://doi.org/10.1371/journal.pgen.1006516

Glucose-ABL1-TOR Signaling Modulates Cell Cycle Tuning to Control Terminal Appressorial Cell Differentiation

Margarita Marroquin-Guzman, Guangchao Sun, Richard A. Wilson

PLOS Genetics: published January 10, 2017 | https://doi.org/10.1371/journal.pgen.1006557

GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary

Chen Jiang, Fan Diao, Yong-Juan Sang, Na Xu, Rui-Lou Zhu, Xiu-Xing Wang, Zhong Chen, Wei-Wei Tao, Bing Yao, Hai-Xiang Sun, Xing-Xu Huang, Bin Xue, Chao-Jun Li

PLOS Genetics: published January 10, 2017 | https://doi.org/10.1371/journal.pgen.1006535

Drosophila Clock Is Required in Brain Pacemaker Neurons to Prevent Premature Locomotor Aging Independently of Its Circadian Function

Alexandra Vaccaro, Abdul-Raouf Issa, Laurent Seugnet, Serge Birman, André Klarsfeld

PLOS Genetics: published January 10, 2017 | https://doi.org/10.1371/journal.pgen.1006507

Two Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegans

Lin Wang, Zhiyu Liu, Herong Shi, Jun Liu

PLOS Genetics: published January 9, 2017 | https://doi.org/10.1371/journal.pgen.1006568

Mutation Accumulation in an Asexual Relative of Arabidopsis

John T. Lovell, Robert J. Williamson, Stephen I. Wright, John K. McKay, Timothy F. Sharbel

PLOS Genetics: published January 9, 2017 | https://doi.org/10.1371/journal.pgen.1006550

Bdf1 Bromodomains Are Essential for Meiosis and the Expression of Meiotic-Specific Genes

Encar García-Oliver, Claire Ramus, Jonathan Perot, Marie Arlotto, Morgane Champleboux, Flore Mietton, Christophe Battail, Anne Boland, Jean-François Deleuze, Myriam Ferro, Yohann Couté, Jérôme Govin

PLOS Genetics: published January 9, 2017 | https://doi.org/10.1371/journal.pgen.1006541

Transcriptional and Post-transcriptional Mechanisms Limit Heading Date 1 (Hd1) Function to Adapt Rice to High Latitudes

Daniela Goretti, Damiano Martignago, Martina Landini, Vittoria Brambilla, Jorge Gómez-Ariza, Nerina Gnesutta, Francesca Galbiati, Silvio Collani, Hiroki Takagi, Ryohei Terauchi, Roberto Mantovani, Fabio Fornara

PLOS Genetics: published January 9, 2017 | https://doi.org/10.1371/journal.pgen.1006530

Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans

Cassandra R. Blanchette, Andrea Thackeray, Paola N. Perrat, Siegfried Hekimi, Claire Y. Bénard

PLOS Genetics: published January 9, 2017 | https://doi.org/10.1371/journal.pgen.1006525

An Arabidopsis Natural Epiallele Maintained by a Feed-Forward Silencing Loop between Histone and DNA

Astrid Agorio, Stéphanie Durand, Elisa Fiume, Cécile Brousse, Isabelle Gy, Matthieu Simon, Sarit Anava, Oded Rechavi, Olivier Loudet, Christine Camilleri, Nicolas Bouché

PLOS Genetics: published January 6, 2017 | https://doi.org/10.1371/journal.pgen.1006551

Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers

Samantha N. McNulty, Jose F. Tort, Gabriel Rinaldi, Kerstin Fischer, Bruce A. Rosa, Pablo Smircich, Santiago Fontenla, Young-Jun Choi, Rahul Tyagi, Kymberlie Hallsworth-Pepin, Victoria H. Mann, Lakshmi Kammili, Patricia S. Latham, Nicolas Dell’Oca, Fernanda Dominguez, Carlos Carmona, Peter U. Fischer, Paul J. Brindley, Makedonka Mitreva

PLOS Genetics: published January 6, 2017 | https://doi.org/10.1371/journal.pgen.1006537

SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention

Piera Calamita, Annarita Miluzio, Arianna Russo, Elisa Pesce, Sara Ricciardi, Farhat Khanim, Cristina Cheroni, Roberta Alfieri, Marilena Mancino, Chiara Gorrini, Grazisa Rossetti, Ivana Peluso, Massimiliano Pagani, Diego L. Medina, Johanna Rommens, Stefano Biffo

PLOS Genetics: published January 5, 2017 | https://doi.org/10.1371/journal.pgen.1006552

BTB-BACK Domain Protein POB1 Suppresses Immune Cell Death by Targeting Ubiquitin E3 ligase PUB17 for Degradation

Beatriz Orosa, Qin He, Joelle Mesmar, Eleanor M. Gilroy, Hazel McLellan, Chengwei Yang, Adam Craig, Mark Bailey, Cunjin Zhang, Jonathan David Moore, Petra C. Boevink, Zhendong Tian, Paul R. J. Birch, Ari Sadanandom

PLOS Genetics: published January 5, 2017 | https://doi.org/10.1371/journal.pgen.1006540

A Signature of Genomic Instability Resulting from Deficient Replication Licensing

Steven C. Pruitt, Maochun Qin, Jianmin Wang, Dimiter Kunnev, Amy Freeland

PLOS Genetics: published January 3, 2017 | https://doi.org/10.1371/journal.pgen.1006547

A Hidden Markov Model Approach for Simultaneously Estimating Local Ancestry and Admixture Time Using Next Generation Sequence Data in Samples of Arbitrary Ploidy

Russell Corbett-Detig, Rasmus Nielsen

PLOS Genetics: published January 3, 2017 | https://doi.org/10.1371/journal.pgen.1006529

Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone

Nitzan Gonen, Alexander Quinn, Helen C. O’Neill, Peter Koopman, Robin Lovell-Badge

PLOS Genetics: published January 3, 2017 | https://doi.org/10.1371/journal.pgen.1006520

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Extremely Rare Polymorphisms in Saccharomyces cerevisiae Allow Inference of the Mutational Spectrum

Yuan O. Zhu, Gavin Sherlock, Dmitri A. Petrov

PLOS Genetics: published January 3, 2017 | https://doi.org/10.1371/journal.pgen.1006455