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March 2016

Facial motor neurons migrate in the plane of the hindbrain neuroepithelium, covering a distance of 100 microns in the course of about ten hours in the zebrafish shown here (red: cranial motor neuron nuclei, green: cranial motor neuron cytoplasm, blue: neuroepithelial nuclei; anterior is to the top, and the migrated facial motor neurons are the bilateral clusters at the bottom of the image). Facial motor neuron migration is tightly connected to the Planar Cell Polarity (PCP) pathway, and using genetic chimeras we show that signaling between the neurons and the planar polarized neuroepithelium controls filopodial dynamics and directional migration. Davey et al.

Image Credit: Cecilia Moens

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