December 2015

Tremendous cellular growth is required to construct a complex dendritic arbor, and it remains unclear how membrane and protein components are transported to support a rapidly growing, polarized dendrite. Shown here is the elaborate dendritic arbor of a PVD sensory neuron in Caenorhabditis elegans. In the PVD neuron, we demonstrate that the regulation of dendritic trafficking by the small GTPase RAB-10 is necessary to pattern a complex dendritic arbor. Taylor et al.

Image Credit: Caitlin Taylor, Shen Lab, Stanford University

Editorial

PLOS Genetics Data Sharing Policy: In Pursuit of Functional Utility

Gregory S. Barsh, Gregory M. Cooper, Gregory P. Copenhaver, Greg Gibson, Mark I. McCarthy, Hua Tang, Scott M. Williams

PLOS Genetics: published December 14, 2015 | https://doi.org/10.1371/journal.pgen.1005716

Perspectives

Catching a (Double-Strand) Break: The Rad51 and Dmc1 Strand Exchange Proteins Can Co-occupy Both Ends of a Meiotic DNA Double-Strand Break

Amy J. MacQueen

PLOS Genetics: published December 31, 2015 | https://doi.org/10.1371/journal.pgen.1005741

Why Are tRNAs Overproduced in the Absence of Maf1, a Negative Regulator of RNAP III, Not Fully Functional?

Magdalena Boguta

PLOS Genetics: published December 31, 2015 | https://doi.org/10.1371/journal.pgen.1005743

Reviews

New Perspectives on DNA and RNA Triplexes As Effectors of Biological Activity

Albino Bacolla, Guliang Wang, Karen M. Vasquez

PLOS Genetics: published December 23, 2015 | https://doi.org/10.1371/journal.pgen.1005696

DNA Methylation: Insights into Human Evolution

Irene Hernando-Herraez, Raquel Garcia-Perez, Andrew J. Sharp, Tomas Marques-Bonet

PLOS Genetics: published December 10, 2015 | https://doi.org/10.1371/journal.pgen.1005661

The Epitranscriptome and Innate Immunity

Mary A. O’Connell, Niamh M. Mannion, Liam P. Keegan

PLOS Genetics: published December 10, 2015 | https://doi.org/10.1371/journal.pgen.1005687

Minor Loops in Major Folds: Enhancer–Promoter Looping, Chromatin Restructuring, and Their Association with Transcriptional Regulation and Disease

Navneet Matharu, Nadav Ahituv

PLOS Genetics: published December 3, 2015 | https://doi.org/10.1371/journal.pgen.1005640

Research Articles

Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Formation and Function in Assisted Fertilization

Yasuhiro Yamauchi, Jonathan M. Riel, Victor Ruthig, Monika A. Ward

PLOS Genetics: published December 31, 2015 | https://doi.org/10.1371/journal.pgen.1005476

Small Rad51 and Dmc1 Complexes Often Co-occupy Both Ends of a Meiotic DNA Double Strand Break

M. Scott Brown, Jennifer Grubb, Annie Zhang, Michael J. Rust, Douglas K. Bishop

PLOS Genetics: published December 31, 2015 | https://doi.org/10.1371/journal.pgen.1005653

RNA Polymerase III Output Is Functionally Linked to tRNA Dimethyl-G26 Modification

Aneeshkumar G. Arimbasseri, Nathan H. Blewett, James R. Iben, Tek N. Lamichhane, Vera Cherkasova, Markus Hafner, Richard J. Maraia

PLOS Genetics: published December 31, 2015 | https://doi.org/10.1371/journal.pgen.1005671

Origins of De Novo Genes in Human and Chimpanzee

Jorge Ruiz-Orera, Jessica Hernandez-Rodriguez, Cristina Chiva, Eduard Sabidó, Ivanela Kondova, Ronald Bontrop, Tomàs Marqués-Bonet, M.Mar Albà

PLOS Genetics: published December 31, 2015 | https://doi.org/10.1371/journal.pgen.1005721

The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling

Nadja Drusenheimer, Bernhard Migdal, Sandra Jäckel, Lena Tveriakhina, Kristina Scheider, Katharina Schulz, Jieny Gröper, Karl Köhrer, Thomas Klein

PLOS Genetics: published December 31, 2015 | https://doi.org/10.1371/journal.pgen.1005749

Viral Transmission Dynamics at Single-Cell Resolution Reveal Transiently Immune Subpopulations Caused by a Carrier State Association

William Cenens, Angela Makumi, Sander K. Govers, Rob Lavigne, Abram Aertsen

PLOS Genetics: published December 31, 2015 | https://doi.org/10.1371/journal.pgen.1005770

Auxin Response Factor SlARF2 Is an Essential Component of the Regulatory Mechanism Controlling Fruit Ripening in Tomato

Yanwei Hao, Guojian Hu, Dario Breitel, Mingchun Liu, Isabelle Mila, Pierre Frasse, Yongyao Fu, Asaph Aharoni, Mondher Bouzayen, Mohamed Zouine

PLOS Genetics: published December 30, 2015 | https://doi.org/10.1371/journal.pgen.1005649

Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF Complexes

Jesse R. Raab, Samuel Resnick, Terry Magnuson

PLOS Genetics: published December 30, 2015 | https://doi.org/10.1371/journal.pgen.1005748

An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies

Wesley K. Thompson, Yunpeng Wang, Andrew J. Schork, Aree Witoelar, Verena Zuber, Shujing Xu, Thomas Werge, Dominic Holland, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Ole A. Andreassen, Anders M. Dale

PLOS Genetics: published December 29, 2015 | https://doi.org/10.1371/journal.pgen.1005717

Arabidopsis COP1 SUPPRESSOR 2 Represses COP1 E3 Ubiquitin Ligase Activity through Their Coiled-Coil Domains Association

Dongqing Xu, Fang Lin, Yan Jiang, Junjie Ling, Chamari Hettiarachchi, Christian Tellgren-Roth, Magnus Holm, Ning Wei, Xing Wang Deng

PLOS Genetics: published December 29, 2015 | https://doi.org/10.1371/journal.pgen.1005747

The Nuclear Matrix Protein Megator Regulates Stem Cell Asymmetric Division through the Mitotic Checkpoint Complex in Drosophila Testes

Ying Liu, Shree Ram Singh, Xiankun Zeng, Jiangsha Zhao, Steven X. Hou

PLOS Genetics: published December 29, 2015 | https://doi.org/10.1371/journal.pgen.1005750

Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation

Santiago Naranjo, Justin D. Smith, Carlo G. Artieri, Mian Zhang, Yiqi Zhou, Michael E. Palmer, Hunter B. Fraser

PLOS Genetics: published December 29, 2015 | https://doi.org/10.1371/journal.pgen.1005751

Gene Regulatory Mechanisms Underlying the Spatial and Temporal Regulation of Target-Dependent Gene Expression in Drosophila Neurons

Anthony J. E. Berndt, Jonathan C. Y. Tang, Marc S. Ridyard, Tianshun Lian, Kathleen Keatings, Douglas W. Allan

PLOS Genetics: published December 29, 2015 | https://doi.org/10.1371/journal.pgen.1005754

Bacterial Proliferation: Keep Dividing and Don't Mind the Gap

Luisa Laureti, Julien Demol, Robert P. Fuchs, Vincent Pagès

PLOS Genetics: published December 29, 2015 | https://doi.org/10.1371/journal.pgen.1005757

Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors

Ying Xu, Futing An, Jolanta A. Borycz, Janusz Borycz, Ian A. Meinertzhagen, Tao Wang

PLOS Genetics: published December 29, 2015 | https://doi.org/10.1371/journal.pgen.1005764

The Sex Determination Gene transformer Regulates Male-Female Differences in Drosophila Body Size

Elizabeth J. Rideout, Marcus S. Narsaiya, Savraj S. Grewal

PLOS Genetics: published December 28, 2015 | https://doi.org/10.1371/journal.pgen.1005683

Dynamic Roles for Small RNAs and DNA Methylation during Ovule and Fiber Development in Allotetraploid Cotton

Qingxin Song, Xueying Guan, Z. Jeffrey Chen

PLOS Genetics: published December 28, 2015 | https://doi.org/10.1371/journal.pgen.1005724

fMiRNA-192 and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma

Yunxia Ge, Xiaodan Yan, Yiguang Jin, Xinyu Yang, Xiang Yu, Liqing Zhou, Sichong Han, Qipeng Yuan, Ming Yang

PLOS Genetics: published December 28, 2015 | https://doi.org/10.1371/journal.pgen.1005726

Methionine Mistranslation Bypasses the Restraint of the Genetic Code to Generate Mutant Proteins with Distinct Activities

Xiaoyun Wang, Tao Pan

PLOS Genetics: published December 28, 2015 | https://doi.org/10.1371/journal.pgen.1005745

Origin-Dependent Inverted-Repeat Amplification: Tests of a Model for Inverted DNA Amplification

Bonita J. Brewer, Celia Payen, Sara C. Di Rienzi, Megan M. Higgins, Giang Ong, Maitreya J. Dunham, M. K. Raghuraman

PLOS Genetics: published December 23, 2015 | https://doi.org/10.1371/journal.pgen.1005699

Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains

Brian J. Bennett, Richard C. Davis, Mete Civelek, Luz Orozco, Judy Wu, Hannah Qi, Calvin Pan, René R. Sevag Packard, Eleazar Eskin, Mujing Yan, Todd Kirchgessner, Zeneng Wang, Xinmin Li, Jill C. Gregory, Stanley L. Hazen, Peter S. Gargalovic, Aldons J. Lusis

PLOS Genetics: published December 22, 2015 | https://doi.org/10.1371/journal.pgen.1005711

Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough

Rebecca K. Holmes, Alex C. Tuck, Chenchen Zhu, Hywel R. Dunn-Davies, Grzegorz Kudla, Sandra Clauder-Munster, Sander Granneman, Lars M. Steinmetz, Christine Guthrie, David Tollervey

PLOS Genetics: published December 22, 2015 | https://doi.org/10.1371/journal.pgen.1005735

Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s

Michele Carbone, Erin G. Flores, Mitsuru Emi, Todd A. Johnson, Tatsuhiko Tsunoda, Dusty Behner, Harriet Hoffman, Mary Hesdorffer, Masaki Nasu, Andrea Napolitano, Amy Powers, Michael Minaai, Francine Baumann, Peter Bryant-Greenwood, Olivia Lauk, Michaela B. Kirschner, Walter Weder, Isabelle Opitz, Harvey I. Pass, Giovanni Gaudino, Sandra Pastorino, Haining Yang

PLOS Genetics: published December 18, 2015 | https://doi.org/10.1371/journal.pgen.1005633

EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes

Yinhua Jin, Nati Ha, Marta Forés, Jinyi Xiang, Christine Gläßer, Julieta Maldera, Gerardo Jiménez, Bruce A. Edgar

PLOS Genetics: published December 18, 2015 | https://doi.org/10.1371/journal.pgen.1005634

Comprehensive Identification of Long Non-coding RNAs in Purified Cell Types from the Brain Reveals Functional LncRNA in OPC Fate Determination

Xiaomin Dong, Kenian Chen, Raquel Cuevas-Diaz Duran, Yanan You, Steven A. Sloan, Ye Zhang, Shan Zong, Qilin Cao, Ben A. Barres, Jia Qian Wu

PLOS Genetics: published December 18, 2015 | https://doi.org/10.1371/journal.pgen.1005669

EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair

Yuehan Wu, Suk-Hee Lee, Elizabeth A. Williamson, Brian L. Reinert, Ju Hwan Cho, Fen Xia, Aruna Shanker Jaiswal, Gayathri Srinivasan, Bhavita Patel, Alexis Brantley, Daohong Zhou, Lijian Shao, Rupak Pathak, Martin Hauer-Jensen, Sudha Singh, Kimi Kong, Xaiohua Wu, Hyun-Suk Kim, Timothy Beissbarth, Jochen Gaedcke, Sandeep Burma, Jac A. Nickoloff, Robert A. Hromas

PLOS Genetics: published December 18, 2015 | https://doi.org/10.1371/journal.pgen.1005675

The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis

Joanna E. Haye, Alison E. Gammie

PLOS Genetics: published December 18, 2015 | https://doi.org/10.1371/journal.pgen.1005719

Brachyury, Foxa2 and the cis-Regulatory Origins of the Notochord

Diana S. José-Edwards, Izumi Oda-Ishii, Jamie E. Kugler, Yale J. Passamaneck, Lavanya Katikala, Yutaka Nibu, Anna Di Gregorio

PLOS Genetics: published December 18, 2015 | https://doi.org/10.1371/journal.pgen.1005730

Seed Dormancy in Arabidopsis Requires Self-Binding Ability of DOG1 Protein and the Presence of Multiple Isoforms Generated by Alternative Splicing

Kazumi Nakabayashi, Melanie Bartsch, Jia Ding, Wim J. J. Soppe

PLOS Genetics: published December 18, 2015 | https://doi.org/10.1371/journal.pgen.1005737

An Endosperm-Associated Cuticle Is Required for Arabidopsis Seed Viability, Dormancy and Early Control of Germination

Julien De Giorgi, Urszula Piskurewicz, Sylvain Loubery, Anne Utz-Pugin, Christophe Bailly, Laurent Mène-Saffrané, Luis Lopez-Molina

PLOS Genetics: published December 17, 2015 | https://doi.org/10.1371/journal.pgen.1005708

GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function

Anmol Kumar, Jaakko Kopra, Kärt Varendi, Lauriina L. Porokuokka, Anne Panhelainen, Satu Kuure, Pepin Marshall, Nina Karalija, Mari-Anne Härma, Carolina Vilenius, Kersti Lilleväli, Triin Tekko, Jelena Mijatovic, Nita Pulkkinen, Madis Jakobson, Maili Jakobson, Roxana Ola, Erik Palm, Maria Lindahl, Ingrid Strömberg, Vootele Võikar, T. Petteri Piepponen, Mart Saarma, Jaan-Olle Andressoo

PLOS Genetics: published December 17, 2015 | https://doi.org/10.1371/journal.pgen.1005710

Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity

Kristen Fortney, Edgar Dobriban, Paolo Garagnani, Chiara Pirazzini, Daniela Monti, Daniela Mari, Gil Atzmon, Nir Barzilai, Claudio Franceschi, Art B. Owen, Stuart K. Kim

PLOS Genetics: published December 17, 2015 | https://doi.org/10.1371/journal.pgen.1005728

The Inflammatory Transcription Factors NFκB, STAT1 and STAT3 Drive Age-Associated Transcriptional Changes in the Human Kidney

Zach K. O’Brown, Eric L. Van Nostrand, John P. Higgins, Stuart K. Kim

PLOS Genetics: published December 17, 2015 | https://doi.org/10.1371/journal.pgen.1005734

Co-evolution of Bacterial Ribosomal Protein S15 with Diverse mRNA Regulatory Structures

Betty L. Slinger, Hunter Newman, Younghan Lee, Shermin Pei, Michelle M. Meyer

PLOS Genetics: published December 16, 2015 | https://doi.org/10.1371/journal.pgen.1005720

Trm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased Translation

Wenjun Deng, I. Ramesh Babu, Dan Su, Shanye Yin, Thomas J. Begley, Peter C. Dedon

PLOS Genetics: published December 15, 2015 | https://doi.org/10.1371/journal.pgen.1005706

A Point Mutation in Suppressor of Cytokine Signalling 2 (Socs2) Increases the Susceptibility to Inflammation of the Mammary Gland while Associated with Higher Body Weight and Size and Higher Milk Production in a Sheep Model

Rachel Rupp, Pavel Senin, Julien Sarry, Charlotte Allain, Christian Tasca, Laeticia Ligat, David Portes, Florent Woloszyn, Olivier Bouchez, Guillaume Tabouret, Mathieu Lebastard, Cécile Caubet, Gilles Foucras, Gwenola Tosser-Klopp

PLOS Genetics: published December 11, 2015 | https://doi.org/10.1371/journal.pgen.1005629

Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae

Joanne M. Kingsbury, Neelam D. Sen, Maria E. Cardenas

PLOS Genetics: published December 11, 2015 | https://doi.org/10.1371/journal.pgen.1005714

Tyro3 Modulates Mertk-Associated Retinal Degeneration

Douglas Vollrath, Douglas Yasumura, Gillie Benchorin, Michael T. Matthes, Wei Feng, Natalie M. Nguyen, Cecilia D. Sedano, Melissa A. Calton, Matthew M. LaVail

PLOS Genetics: published December 11, 2015 | https://doi.org/10.1371/journal.pgen.1005723

Reproductive Aging Drives Protein Accumulation in the Uterus and Limits Lifespan in C. elegans

Stephanie M. Zimmerman, Izumi V. Hinkson, Joshua E. Elias, Stuart K. Kim

PLOS Genetics: published December 11, 2015 | https://doi.org/10.1371/journal.pgen.1005725

dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest

Rebecca E. W. Kaplan, Yutao Chen, Brad T. Moore, James M. Jordan, Colin S. Maxwell, Adam J. Schindler, L. Ryan Baugh

PLOS Genetics: published December 11, 2015 | https://doi.org/10.1371/journal.pgen.1005731

Understanding Biases in Ribosome Profiling Experiments Reveals Signatures of Translation Dynamics in Yeast

Jeffrey A. Hussmann, Stephanie Patchett, Arlen Johnson, Sara Sawyer, William H. Press

PLOS Genetics: published December 11, 2015 | https://doi.org/10.1371/journal.pgen.1005732

DLK-1/p38 MAP Kinase Signaling Controls Cilium Length by Regulating RAB-5 Mediated Endocytosis in Caenorhabditis elegans

Aniek van der Vaart, Suzanne Rademakers, Gert Jansen

PLOS Genetics: published December 11, 2015 | https://doi.org/10.1371/journal.pgen.1005733

Retromer Is Essential for Autophagy-Dependent Plant Infection by the Rice Blast Fungus

Wenhui Zheng, Jie Zhou, Yunlong He, Qiurong Xie, Ahai Chen, Huawei Zheng, Lei Shi, Xu Zhao, Chengkang Zhang, Qingping Huang, Kunhai Fang, Guodong Lu, Daniel J. Ebbole, Guangpu Li, Naweed I. Naqvi, Zonghua Wang

PLOS Genetics: published December 10, 2015 | https://doi.org/10.1371/journal.pgen.1005704

The Drosophila Zinc Finger Transcription Factor Ouija Board Controls Ecdysteroid Biosynthesis through Specific Regulation of spookier

Tatsuya Komura-Kawa, Keiko Hirota, Yuko Shimada-Niwa, Rieko Yamauchi, MaryJane Shimell, Tetsuro Shinoda, Akiyoshi Fukamizu, Michael B. O’Connor, Ryusuke Niwa

PLOS Genetics: published December 10, 2015 | https://doi.org/10.1371/journal.pgen.1005712

Hnrnph1 Is A Quantitative Trait Gene for Methamphetamine Sensitivity

Neema Yazdani, Clarissa C. Parker, Ying Shen, Eric R. Reed, Michael A. Guido, Loren A. Kole, Stacey L. Kirkpatrick, Jackie E. Lim, Greta Sokoloff, Riyan Cheng, W. Evan Johnson, Abraham A. Palmer, Camron D. Bryant

PLOS Genetics: published December 10, 2015 | https://doi.org/10.1371/journal.pgen.1005713

Skp1 Independent Function of Cdc53/Cul1 in F-box Protein Homeostasis

Radhika Mathur, James L. Yen, Peter Kaiser

PLOS Genetics: published December 10, 2015 | https://doi.org/10.1371/journal.pgen.1005727

Probing Xist RNA Structure in Cells Using Targeted Structure-Seq

Rui Fang, Walter N. Moss, Michael Rutenberg-Schoenberg, Matthew D. Simon

PLOS Genetics: published December 8, 2015 | https://doi.org/10.1371/journal.pgen.1005668

Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid

Fiona Semple, Heather MacPherson, Sheila Webb, Fiona Kilanowski, Laura Lettice, Sarah L. McGlasson, Ann P. Wheeler, Valerie Chen, Glenn L. Millhauser, Lauren Melrose, Donald J. Davidson, Julia R. Dorin

PLOS Genetics: published December 8, 2015 | https://doi.org/10.1371/journal.pgen.1005673

Integration Analysis of Three Omics Data Using Penalized Regression Methods: An Application to Bladder Cancer

Silvia Pineda, Francisco X. Real, Manolis Kogevinas, Alfredo Carrato, Stephen J. Chanock, Núria Malats, Kristel Van Steen

PLOS Genetics: published December 8, 2015 | https://doi.org/10.1371/journal.pgen.1005689

Compound Heterozygosity for Y Box Proteins Causes Sterility Due to Loss of Translational Repression

Elizabeth Snyder, Ramani Soundararajan, Manju Sharma, Andrea Dearth, Benjamin Smith, Robert E. Braun

PLOS Genetics: published December 8, 2015 | https://doi.org/10.1371/journal.pgen.1005690

Multifactorial Competition and Resistance in a Two-Species Bacterial System

Anupama Khare, Saeed Tavazoie

PLOS Genetics: published December 8, 2015 | https://doi.org/10.1371/journal.pgen.1005715

Estimating Information Processing in a Memory System: The Utility of Meta-analytic Methods for Genetics

Tugce Yildizoglu, Jan-Marek Weislogel, Farhan Mohammad, Edwin S.-Y. Chan, Pryseley N. Assam, Adam Claridge-Chang

PLOS Genetics: published December 8, 2015 | https://doi.org/10.1371/journal.pgen.1005718

Escape from Lethal Bacterial Competition through Coupled Activation of Antibiotic Resistance and a Mobilized Subpopulation

Reed M. Stubbendieck, Paul D. Straight

PLOS Genetics: published December 8, 2015 | https://doi.org/10.1371/journal.pgen.1005722

Sex Pheromones of C. elegans Males Prime the Female Reproductive System and Ameliorate the Effects of Heat Stress

Erin Z. Aprison, Ilya Ruvinsky

PLOS Genetics: published December 8, 2015 | https://doi.org/10.1371/journal.pgen.1005729

Kicking against the PRCs – A Domesticated Transposase Antagonises Silencing Mediated by Polycomb Group Proteins and Is an Accessory Component of Polycomb Repressive Complex 2

Shih Chieh Liang, Ben Hartwig, Pumi Perera, Santiago Mora-García, Erica de Leau, Harry Thornton, Flavia Lima de Alves, Juri Rapsilber, Suxin Yang, Geo Velikkakam James, Korbinian Schneeberger, E. Jean Finnegan, Franziska Turck, Justin Goodrich

PLOS Genetics: published December 7, 2015 | https://doi.org/10.1371/journal.pgen.1005660

Stable Pseudohyphal Growth in Budding Yeast Induced by Synergism between Septin Defects and Altered MAP-kinase Signaling

Junwon Kim, Mark D. Rose

PLOS Genetics: published December 7, 2015 | https://doi.org/10.1371/journal.pgen.1005684

Comparative Genomic Analyses of the Human NPHP1 Locus Reveal Complex Genomic Architecture and Its Regional Evolution in Primates

Bo Yuan, Pengfei Liu, Aditya Gupta, Christine R. Beck, Anusha Tejomurtula, Ian M. Campbell, Tomasz Gambin, Alexandra D. Simmons, Marjorie A. Withers, R. Alan Harris, Jeffrey Rogers, David C. Schwartz, James R. Lupski

PLOS Genetics: published December 7, 2015 | https://doi.org/10.1371/journal.pgen.1005686

Developmental Dynamics of X-Chromosome Dosage Compensation by the DCC and H4K20me1 in C. elegans

Maxwell Kramer, Anna-Lena Kranz, Amanda Su, Lara H. Winterkorn, Sarah Elizabeth Albritton, Sevinc Ercan

PLOS Genetics: published December 7, 2015 | https://doi.org/10.1371/journal.pgen.1005698

Genomic Insights into the Ancestry and Demographic History of South America

Julian R. Homburger, Andrés Moreno-Estrada, Christopher R. Gignoux, Dominic Nelson, Elena Sanchez, Patricia Ortiz-Tello, Bernardo A. Pons-Estel, Eduardo Acevedo-Vasquez, Pedro Miranda, Carl D. Langefeld, Simon Gravel, Marta E. Alarcón-Riquelme, Carlos D. Bustamante

PLOS Genetics: published December 4, 2015 | https://doi.org/10.1371/journal.pgen.1005602

Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Parallelism at the Molecular Sequence Level

Chandrasekhar Natarajan, Joana Projecto-Garcia, Hideaki Moriyama, Roy E. Weber, Violeta Muñoz-Fuentes, Andy J. Green, Cecilia Kopuchian, Pablo L. Tubaro, Luis Alza, Mariana Bulgarella, Matthew M. Smith, Robert E. Wilson, Angela Fago, Kevin G. McCracken, Jay F. Storz

PLOS Genetics: published December 4, 2015 | https://doi.org/10.1371/journal.pgen.1005681

Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish

Adi Shamay-Ramot, Khen Khermesh, Hagit T. Porath, Michal Barak, Yishay Pinto, Chaim Wachtel, Alona Zilberberg, Tali Lerer-Goldshtein, Sol Efroni, Erez Y. Levanon, Lior Appelbaum

PLOS Genetics: published December 4, 2015 | https://doi.org/10.1371/journal.pgen.1005702

LncRNA-HIT Functions as an Epigenetic Regulator of Chondrogenesis through Its Recruitment of p100/CBP Complexes

Hanqian L. Carlson, Jeffrey J. Quinn, Yul W. Yang, Chelsea K. Thornburg, Howard Y. Chang, H. Scott Stadler

PLOS Genetics: published December 3, 2015 | https://doi.org/10.1371/journal.pgen.1005680

RAB-10 Regulates Dendritic Branching by Balancing Dendritic Transport

Caitlin A. Taylor, Jing Yan, Audrey S. Howell, Xintong Dong, Kang Shen

PLOS Genetics: published December 3, 2015 | https://doi.org/10.1371/journal.pgen.1005695

Trehalose Accumulation Triggers Autophagy during Plant Desiccation

Brett Williams, Isaac Njaci, Lalehvash Moghaddam, Hao Long, Martin B Dickman, Xiuren Zhang, Sagadevan Mundree

PLOS Genetics: published December 3, 2015 | https://doi.org/10.1371/journal.pgen.1005705

A Simple Model-Based Approach to Inferring and Visualizing Cancer Mutation Signatures

Yuichi Shiraishi, Georg Tremmel, Satoru Miyano, Matthew Stephens

PLOS Genetics: published December 2, 2015 | https://doi.org/10.1371/journal.pgen.1005657

Top2 and Sgs1-Top3 Act Redundantly to Ensure rDNA Replication Termination

Kamilla Mundbjerg, Signe W. Jørgensen, Jacob Fredsøe, Ida Nielsen, Jakob Madsen Pedersen, Iben Bach Bentsen, Michael Lisby, Lotte Bjergbaek, Anni H Andersen

PLOS Genetics: published December 2, 2015 | https://doi.org/10.1371/journal.pgen.1005697

The Ribosome Biogenesis Protein Nol9 Is Essential for Definitive Hematopoiesis and Pancreas Morphogenesis in Zebrafish

Ewa Bielczyk-Maczyńska, Laure Lam Hung, Lauren Ferreira, Tobias Fleischmann, Félix Weis, Antonio Fernández-Pevida, Steven A. Harvey, Neha Wali, Alan J. Warren, Inês Barroso, Derek L. Stemple, Ana Cvejic

PLOS Genetics: published December 1, 2015 | https://doi.org/10.1371/journal.pgen.1005677

Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome

Luke Isbel, Rahul Srivastava, Harald Oey, Alex Spurling, Lucia Daxinger, Hamsa Puthalakath, Emma Whitelaw

PLOS Genetics: published December 1, 2015 | https://doi.org/10.1371/journal.pgen.1005693

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

Martijn van de Bunt, Jocelyn E. Manning Fox, Xiaoqing Dai, Amy Barrett, Caleb Grey, Lei Li, Amanda J. Bennett, Paul R. Johnson, Raymond V. Rajotte, Kyle J. Gaulton, Emmanouil T. Dermitzakis, Patrick E. MacDonald, Mark I. McCarthy, Anna L. Gloyn

PLOS Genetics: published December 1, 2015 | https://doi.org/10.1371/journal.pgen.1005694

Recruitment of Mediator Complex by Cell Type and Stage-Specific Factors Required for Tissue-Specific TAF Dependent Gene Activation in an Adult Stem Cell Lineage

Chenggang Lu, Margaret T. Fuller

PLOS Genetics: published December 1, 2015 | https://doi.org/10.1371/journal.pgen.1005701

Deep Reads

"Women Who Don't Give a Crap"

Holly Tabor

PLOS Genetics: published December 23, 2015 | https://doi.org/10.1371/journal.pgen.1005736

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RAB-10 regulates dendritic branching by balancing dendritic transport

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