May 2014

Copy Number Variation Is a Fundamental Aspect of the Placental Genome

Roberta L. Hannibal, Edward B. Chuong, Juan Carlos Rivera-Mulia, David M. Gilbert, Anton Valouev, Julie C. Baker

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004290

GOLPH3 Is Essential for Contractile Ring Formation and Rab11 Localization to the Cleavage Site during Cytokinesis in Drosophila melanogaster

Stefano Sechi, Gianni Colotti, Giorgio Belloni, Vincenzo Mattei, Anna Frappaolo, Grazia D. Raffa, Margaret T. Fuller, Maria Grazia Giansanti

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004305

Heterogeneity in the Frequency and Characteristics of Homologous Recombination in Pneumococcal Evolution

Rafal Mostowy, Nicholas J. Croucher, William P. Hanage, Simon R. Harris, Stephen Bentley, Christophe Fraser

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004300

R-loops Associated with Triplet Repeat Expansions Promote Gene Silencing in Friedreich Ataxia and Fragile X Syndrome

Matthias Groh, Michele M. P. Lufino, Richard Wade-Martins, Natalia Gromak

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004318

Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction

Louise V. Wain, Ian Sayers, María Soler Artigas, Michael A. Portelli, Eleftheria Zeggini, Ma'en Obeidat, Don D. Sin, Yohan Bossé, David Nickle, Corry-Anke Brandsma, Anders Malarstig, Ciara Vangjeli, Scott A. Jelinsky, Sally John, Iain Kilty, Tricia McKeever, Nick R. G. Shrine, James P. Cook, Shrina Patel, Tim D. Spector, Edward J. Hollox, Ian P. Hall, Martin D. Tobin

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004314

Drosha Promotes Splicing of a Pre-microRNA-like Alternative Exon

Mallory A. Havens, Ashley A. Reich, Michelle L. Hastings

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004312

Allele-Specific Genome-wide Profiling in Human Primary Erythroblasts Reveal Replication Program Organization

Rituparna Mukhopadhyay, Julien Lajugie, Nicolas Fourel, Ari Selzer, Michael Schizas, Boris Bartholdy, Jessica Mar, Chii Mei Lin, Melvenia M. Martin, Michael Ryan, Mirit I. Aladjem, Eric E. Bouhassira

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004319

Null Mutation in PGAP1 Impairing Gpi-Anchor Maturation in Patients with Intellectual Disability and Encephalopathy

Yoshiko Murakami, Hasan Tawamie, Yusuke Maeda, Christian Büttner, Rebecca Buchert, Farah Radwan, Stefanie Schaffer, Heinrich Sticht, Michael Aigner, André Reis, Taroh Kinoshita, Rami Abou Jamra

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004320

The Impairment of MAGMAS Function in Human Is Responsible for a Severe Skeletal Dysplasia

Cybel Mehawej, Agnès Delahodde, Laurence Legeai-Mallet, Valérie Delague, Nabil Kaci, Jean-Pierre Desvignes, Zoha Kibar, José-Mario Capo-Chichi, Eliane Chouery, Arnold Munnich, Valérie Cormier-Daire, André Mégarbané

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004311

Genetic Interactions Involving Five or More Genes Contribute to a Complex Trait in Yeast

Matthew B. Taylor, Ian M. Ehrenreich

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004324

Drosophila melanogaster Hox Transcription Factors Access the RNA Polymerase II Machinery through Direct Homeodomain Binding to a Conserved Motif of Mediator Subunit Med19

Muriel Boube, Bruno Hudry, Clément Immarigeon, Yannick Carrier, Sandra Bernat-Fabre, Samir Merabet, Yacine Graba, Henri-Marc Bourbon, David L. Cribbs

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004303

Loss of Function Mutation in the Palmitoyl-Transferase HHAT Leads to Syndromic 46,XY Disorder of Sex Development by Impeding Hedgehog Protein Palmitoylation and Signaling

Patrick Callier, Pierre Calvel, Armine Matevossian, Periklis Makrythanasis, Pascal Bernard, Hiroshi Kurosaka, Anne Vannier, Christel Thauvin-Robinet, Christelle Borel, Séverine Mazaud-Guittot, Antoine Rolland, Christèle Desdoits-Lethimonier, Michel Guipponi, Céline Zimmermann, Isabelle Stévant, Françoise Kuhne, Béatrice Conne, Federico Santoni, Sandy Lambert, Frederic Huet, Francine Mugneret, Jadwiga Jaruzelska, Laurence Faivre, Dagmar Wilhelm, Bernard Jégou, Paul A. Trainor, Marilyn D. Resh, Stylianos E. Antonarakis, Serge Nef

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004340

Heritable Transmission of Stress Resistance by High Dietary Glucose in Caenorhabditis elegans

Arnaud Tauffenberger, J. Alex Parker

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004346

The Spatiotemporal Program of DNA Replication Is Associated with Specific Combinations of Chromatin Marks in Human Cells

Franck Picard, Jean-Charles Cadoret, Benjamin Audit, Alain Arneodo, Adriana Alberti, Christophe Battail, Laurent Duret, Marie-Noelle Prioleau

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004282

A Novel C₂H₂ Transcription Factor that Regulates gliA Expression Interdependently with GliZ in Aspergillus fumigatus

Taylor J. Schoberle, C. Kim Nguyen-Coleman, Jennifer Herold, Ally Yang, Matt Weirauch, Timothy R. Hughes, John S. McMurray, Gregory S. May

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004336

Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification

Christoph Ruckenstuhl, Christine Netzberger, Iryna Entfellner, Didac Carmona-Gutierrez, Thomas Kickenweiz, Slaven Stekovic, Christina Gleixner, Christian Schmid, Lisa Klug, Alice G. Sorgo, Tobias Eisenberg, Sabrina Büttner, Guillermo Mariño, Rafal Koziel, Pidder Jansen-Dürr, Kai-Uwe Fröhlich, Guido Kroemer, Frank Madeo

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004347

Mutations in Four Glycosyl Hydrolases Reveal a Highly Coordinated Pathway for Rhodopsin Biosynthesis and N-Glycan Trimming in Drosophila melanogaster

Erica E. Rosenbaum, Eva Vasiljevic, Kimberley S. Brehm, Nansi Jo Colley

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004349

Single Nucleotide Variants in Transcription Factors Associate More Tightly with Phenotype than with Gene Expression

Priya Sudarsanam, Barak A. Cohen

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004325

An In Vivo EGF Receptor Localization Screen in C. elegans Identifies the Ezrin Homolog ERM-1 as a Temporal Regulator of Signaling

Andrea Haag, Peter Gutierrez, Alessandra Bühler, Michael Walser, Qiutan Yang, Maeva Langouët, David Kradolfer, Erika Fröhli, Christina J. Herrmann, Alex Hajnal, Juan M. Escobar-Restrepo

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004341

Revertant Mutation Releases Confined Lethal Mutation, Opening Pandora's Box: A Novel Genetic Pathogenesis

Yasushi Ogawa, Takuya Takeichi, Michihiro Kono, Nobuyuki Hamajima, Toshimichi Yamamoto, Kazumitsu Sugiura, Masashi Akiyama

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004276

Allelic Expression of Deleterious Protein-Coding Variants across Human Tissues

Kimberly R. Kukurba, Rui Zhang, Xin Li, Kevin S. Smith, David A. Knowles, Meng How Tan, Robert Piskol, Monkol Lek, Michael Snyder, Daniel G. MacArthur, Jin Billy Li, Stephen B. Montgomery

PLOS Genetics: published May 1, 2014 | https://doi.org/10.1371/journal.pgen.1004304

dGTP Starvation in Escherichia coli Provides New Insights into the Thymineless-Death Phenomenon

Mark Itsko, Roel M. Schaaper

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004310

Enhanced Interaction between Pseudokinase and Kinase Domains in Gcn2 stimulates eIF2α Phosphorylation in Starved Cells

Sebastien Lageix, Stefan Rothenburg, Thomas E. Dever, Alan G. Hinnebusch

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004326

Genome Sequencing and Comparative Genomics of the Broad Host-Range Pathogen Rhizoctonia solani AG8

James K. Hane, Jonathan P. Anderson, Angela H. Williams, Jana Sperschneider, Karam B. Singh

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004281

Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease

Sandra Tenreiro, Madalena M. Reimão-Pinto, Pedro Antas, José Rino, Donata Wawrzycka, Diana Macedo, Rita Rosado-Ramos, Triana Amen, Meytal Waiss, Filipa Magalhães, Andreia Gomes, Cláudia N. Santos, Daniel Kaganovich, Tiago Fleming Outeiro

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004302

RPM-1 Uses Both Ubiquitin Ligase and Phosphatase-Based Mechanisms to Regulate DLK-1 during Neuronal Development

Scott T. Baker, Karla J. Opperman, Erik D. Tulgren, Shane M. Turgeon, Willy Bienvenut, Brock Grill

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004297

Biased, Non-equivalent Gene-Proximal and -Distal Binding Motifs of Orphan Nuclear Receptor TR4 in Primary Human Erythroid Cells

Lihong Shi, M. C. Sierant, Katherine Gurdziel, Fan Zhu, Shuaiying Cui, Katarzyna E. Kolodziej, John Strouboulis, Yuanfang Guan, Osamu Tanabe, Kim-Chew Lim, James Douglas Engel

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004339

Genetic Dissection of the Drosophila melanogaster Female Head Transcriptome Reveals Widespread Allelic Heterogeneity

Elizabeth G. King, Brian J. Sanderson, Casey L. McNeil, Anthony D. Long, Stuart J. Macdonald

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004322

Mlh2 Is an Accessory Factor for DNA Mismatch Repair in Saccharomyces cerevisiae

Christopher S. Campbell, Hans Hombauer, Anjana Srivatsan, Nikki Bowen, Kerstin Gries, Arshad Desai, Christopher D. Putnam, Richard D. Kolodner

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004327

Epistatically Interacting Substitutions Are Enriched during Adaptive Protein Evolution

Lizhi Ian Gong, Jesse D. Bloom

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004328

Retinoid-X-Receptors (α/β) in Melanocytes Modulate Innate Immune Responses and Differentially Regulate Cell Survival following UV Irradiation

Daniel J. Coleman, Gloria Garcia, Stephen Hyter, Hyo Sang Jang, Sharmeen Chagani, Xiaobo Liang, Lionel Larue, Gitali Ganguli-Indra, Arup K. Indra

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004321

Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2

Marzia Scortegagna, Hyungsoo Kim, Jian-Liang Li, Hang Yao, Laurence M. Brill, Jaeseok Han, Eric Lau, David Bowtell, Gabriel Haddad, Randal J. Kaufman, Ze'ev A. Ronai

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004348

Population Genomic Analysis of Ancient and Modern Genomes Yields New Insights into the Genetic Ancestry of the Tyrolean Iceman and the Genetic Structure of Europe

Martin Sikora, Meredith L. Carpenter, Andres Moreno-Estrada, Brenna M. Henn, Peter A. Underhill, Federico Sánchez-Quinto, Ilenia Zara, Maristella Pitzalis, Carlo Sidore, Fabio Busonero, Andrea Maschio, Andrea Angius, Chris Jones, Javier Mendoza-Revilla, Georgi Nekhrizov, Diana Dimitrova, Nikola Theodossiev, Timothy T. Harkins, Andreas Keller, Frank Maixner, Albert Zink, Goncalo Abecasis, Serena Sanna, Francesco Cucca, Carlos D. Bustamante

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004353

Extensive Diversity of Prion Strains Is Defined by Differential Chaperone Interactions and Distinct Amyloidogenic Regions

Kevin C. Stein, Heather L. True

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004337

A Dominant-Negative Mutation of Mouse Lmx1b Causes Glaucoma and Is Semi-lethal via LBD1-Mediated Dimerisation

Sally H. Cross, Danilo G. Macalinao, Lisa McKie, Lorraine Rose, Alison L. Kearney, Joe Rainger, Caroline Thaung, Margaret Keighren, Shalini Jadeja, Katrine West, Stephen C. Kneeland, Richard S. Smith, Gareth R. Howell, Fiona Young, Morag Robertson, Rob van t' Hof, Simon W. M. John, Ian J. Jackson

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004359

A Lack of Parasitic Reduction in the Obligate Parasitic Green Alga Helicosporidium

Jean-François Pombert, Nicolas Achille Blouin, Chris Lane, Drion Boucias, Patrick J. Keeling

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004355

Meiotic Drive Impacts Expression and Evolution of X-Linked Genes in Stalk-Eyed Flies

Josephine A. Reinhardt, Cara L. Brand, Kimberly A. Paczolt, Philip M. Johns, Richard H. Baker, Gerald S. Wilkinson

PLOS Genetics: published May 15, 2014 | https://doi.org/10.1371/journal.pgen.1004362

Hyperactivated Wnt Signaling Induces Synthetic Lethal Interaction with Rb Inactivation by Elevating TORC1 Activities

Tianyi Zhang, Yang Liao, Fu-Ning Hsu, Robin Zhang, Jennifer S. Searle, Xun Pei, Xuan Li, Hyung Don Ryoo, Jun-Yuan Ji, Wei Du

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004357

Predicting the Minimal Translation Apparatus: Lessons from the Reductive Evolution of Mollicutes

Henri Grosjean, Marc Breton, Pascal Sirand-Pugnet, Florence Tardy, François Thiaucourt, Christine Citti, Aurélien Barré, Satoko Yoshizawa, Dominique Fourmy, Valérie de Crécy-Lagard, Alain Blanchard

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004363

Paternal Poly (ADP-ribose) Metabolism Modulates Retention of Inheritable Sperm Histones and Early Embryonic Gene Expression

Motomasa Ihara, Mirella L. Meyer-Ficca, N. Adrian Leu, Shilpa Rao, Fan Li, Brian D. Gregory, Irina A. Zalenskaya, Richard M. Schultz, Ralph G. Meyer

PLOS Genetics: published May 8, 2014 | https://doi.org/10.1371/journal.pgen.1004317

Genome-Wide Inference of Ancestral Recombination Graphs

Matthew D. Rasmussen, Melissa J. Hubisz, Ilan Gronau, Adam Siepel

PLOS Genetics: published May 15, 2014 | https://doi.org/10.1371/journal.pgen.1004342

Intron Retention in the 5′UTR of the Novel ZIF2 Transporter Enhances Translation to Promote Zinc Tolerance in Arabidopsis

Estelle Remy, Tânia R. Cabrito, Rita A. Batista, Mohamed A. M. Hussein, Miguel C. Teixeira, Alekos Athanasiadis, Isabel Sá-Correia, Paula Duque

PLOS Genetics: published May 15, 2014 | https://doi.org/10.1371/journal.pgen.1004375

Mutations in the Cholesterol Transporter Gene ABCA5 Are Associated with Excessive Hair Overgrowth

Gina M. DeStefano, Mazen Kurban, Kwame Anyane-Yeboa, Claudia Dall'Armi, Gilbert Di Paolo, Heather Feenstra, Nanette Silverberg, Luis Rohena, Larissa D. López-Cepeda, Vaidehi Jobanputra, Katherine A. Fantauzzo, Maija Kiuru, Marija Tadin-Strapps, Antonio Sobrino, Anna Vitebsky, Dorothy Warburton, Brynn Levy, Julio C. Salas-Alanis, Angela M. Christiano

PLOS Genetics: published May 15, 2014 | https://doi.org/10.1371/journal.pgen.1004333

G×G×E for Lifespan in Drosophila: Mitochondrial, Nuclear, and Dietary Interactions that Modify Longevity

Chen-Tseh Zhu, Paul Ingelmo, David M. Rand

PLOS Genetics: published May 15, 2014 | https://doi.org/10.1371/journal.pgen.1004354

Insights into the Genetic Structure and Diversity of 38 South Asian Indians from Deep Whole-Genome Sequencing

Lai-Ping Wong, Jason Kuan-Han Lai, Woei-Yuh Saw, Rick Twee-Hee Ong, Anthony Youzhi Cheng, Nisha Esakimuthu Pillai, Xuanyao Liu, Wenting Xu, Peng Chen, Jia-Nee Foo, Linda Wei-Lin Tan, Seok-Hwee Koo, Richie Soong, Markus Rene Wenk, Wei-Yen Lim, Chiea-Chuen Khor, Peter Little, Kee-Seng Chia, Yik-Ying Teo

PLOS Genetics: published May 15, 2014 | https://doi.org/10.1371/journal.pgen.1004377

Spermatid Cyst Polarization in Drosophila Depends upon apkc and the CPEB Family Translational Regulator orb2

Shuwa Xu, Sanjay Tyagi, Paul Schedl

PLOS Genetics: published May 15, 2014 | https://doi.org/10.1371/journal.pgen.1004380

EDR1 Physically Interacts with MKK4/MKK5 and Negatively Regulates a MAP Kinase Cascade to Modulate Plant Innate Immunity

Chunzhao Zhao, Haozhen Nie, Qiujing Shen, Shuqun Zhang, Wolfgang Lukowitz, Dingzhong Tang

PLOS Genetics: published May 15, 2014 | https://doi.org/10.1371/journal.pgen.1004389

p53 Requires the Stress Sensor USF1 to Direct Appropriate Cell Fate Decision

Amine Bouafia, Sébastien Corre, David Gilot, Nicolas Mouchet, Sharon Prince, Marie-Dominique Galibert

PLOS Genetics: published May 15, 2014 | https://doi.org/10.1371/journal.pgen.1004309

A Mutation in the FAM83G Gene in Dogs with Hereditary Footpad Hyperkeratosis (HFH)

Michaela Drögemüller, Vidhya Jagannathan, Doreen Becker, Cord Drögemüller, Claude Schelling, Jocelyn Plassais, Cécile Kaerle, Caroline Dufaure de Citres, Anne Thomas, Eliane J. Müller, Monika M. Welle, Petra Roosje, Tosso Leeb

PLOS Genetics: published May 15, 2014 | https://doi.org/10.1371/journal.pgen.1004370

A HECT Ubiquitin-Protein Ligase as a Novel Candidate Gene for Altered Quinine and Quinidine Responses in Plasmodium falciparum

Cecilia P. Sanchez, Chia-Hao Liu, Sybille Mayer, Astutiati Nurhasanah, Marek Cyrklaff, Jianbing Mu, Michael T. Ferdig, Wilfred D. Stein, Michael Lanzer

PLOS Genetics: published May 15, 2014 | https://doi.org/10.1371/journal.pgen.1004382

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

Claudia Giambartolomei, Damjan Vukcevic, Eric E. Schadt, Lude Franke, Aroon D. Hingorani, Chris Wallace, Vincent Plagnol

PLOS Genetics: published May 15, 2014 | https://doi.org/10.1371/journal.pgen.1004383

Phosphorylation of a WRKY Transcription Factor by MAPKs Is Required for Pollen Development and Function in Arabidopsis

Yuefeng Guan, Xiangzong Meng, Reshma Khanna, Erica LaMontagne, Yidong Liu, Shuqun Zhang

PLOS Genetics: published May 15, 2014 | https://doi.org/10.1371/journal.pgen.1004384

Genes That Bias Mendelian Segregation

Pierre Grognet, Hervé Lalucque, Fabienne Malagnac, Philippe Silar

PLOS Genetics: published May 15, 2014 | https://doi.org/10.1371/journal.pgen.1004387

Retinoic Acid-Related Orphan Receptor γ (RORγ): A Novel Participant in the Diurnal Regulation of Hepatic Gluconeogenesis and Insulin Sensitivity

Yukimasa Takeda, Hong Soon Kang, Johannes Freudenberg, Laura M. DeGraff, Raja Jothi, Anton M. Jetten

PLOS Genetics: published May 15, 2014 | https://doi.org/10.1371/journal.pgen.1004331

Selectivity in Genetic Association with Sub-classified Migraine in Women

Daniel I. Chasman, Verneri Anttila, Julie E. Buring, Paul M. Ridker, Markus Schürks, Tobias Kurth, on behalf of the International Headache Genetics Consortium

PLOS Genetics: published May 22, 2014 | https://doi.org/10.1371/journal.pgen.1004366

Scribble Modulates the MAPK/Fra1 Pathway to Disrupt Luminal and Ductal Integrity and Suppress Tumour Formation in the Mammary Gland

Nathan J. Godde, Julie M. Sheridan, Lorey K. Smith, Helen B. Pearson, Kara L. Britt, Ryan C. Galea, Laura L. Yates, Jane E. Visvader, Patrick O. Humbert

PLOS Genetics: published May 22, 2014 | https://doi.org/10.1371/journal.pgen.1004323

Octopamine Neuromodulation Regulates Gr32a-Linked Aggression and Courtship Pathways in Drosophila Males

Jonathan C. Andrews, María Paz Fernández, Qin Yu, Greg P. Leary, Adelaine K. W. Leung, Michael P. Kavanaugh, Edward A. Kravitz, Sarah J. Certel

PLOS Genetics: published May 22, 2014 | https://doi.org/10.1371/journal.pgen.1004356

Recent Mitochondrial DNA Mutations Increase the Risk of Developing Common Late-Onset Human Diseases

Gavin Hudson, Aurora Gomez-Duran, Ian J. Wilson, Patrick F. Chinnery

PLOS Genetics: published May 22, 2014 | https://doi.org/10.1371/journal.pgen.1004369

SHP2 Regulates Chondrocyte Terminal Differentiation, Growth Plate Architecture and Skeletal Cell Fates

Margot E. Bowen, Ugur M. Ayturk, Kyle C. Kurek, Wentian Yang, Matthew L. Warman

PLOS Genetics: published May 29, 2014 | https://doi.org/10.1371/journal.pgen.1004364

Genome-Wide Nucleosome Positioning Is Orchestrated by Genomic Regions Associated with DNase I Hypersensitivity in Rice

Yufeng Wu, Wenli Zhang, Jiming Jiang

PLOS Genetics: published May 22, 2014 | https://doi.org/10.1371/journal.pgen.1004378

Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype

Iori Sakakibara, Marc Santolini, Arnaud Ferry, Vincent Hakim, Pascal Maire

PLOS Genetics: published May 22, 2014 | https://doi.org/10.1371/journal.pgen.1004386

PINK1-Parkin Pathway Activity Is Regulated by Degradation of PINK1 in the Mitochondrial Matrix

Ruth E. Thomas, Laurie A. Andrews, Jonathon L. Burman, Wen-Yang Lin, Leo J. Pallanck

PLOS Genetics: published May 29, 2014 | https://doi.org/10.1371/journal.pgen.1004279

Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease in Zebrafish

Deanna L. Howarth, Claudia Lindtner, Ana M. Vacaru, Ravi Sachidanandam, Orkhontuya Tsedensodnom, Taisa Vasilkova, Christoph Buettner, Kirsten C. Sadler

PLOS Genetics: published May 29, 2014 | https://doi.org/10.1371/journal.pgen.1004335

Ras-Mediated Deregulation of the Circadian Clock in Cancer

Angela Relógio, Philippe Thomas, Paula Medina-Pérez, Silke Reischl, Sander Bervoets, Ewa Gloc, Pamela Riemer, Shila Mang-Fatehi, Bert Maier, Reinhold Schäfer, Ulf Leser, Hanspeter Herzel, Achim Kramer, Christine Sers

PLOS Genetics: published May 29, 2014 | https://doi.org/10.1371/journal.pgen.1004338

The Impact of Population Demography and Selection on the Genetic Architecture of Complex Traits

Kirk E. Lohmueller

PLOS Genetics: published May 29, 2014 | https://doi.org/10.1371/journal.pgen.1004379

A Genome-Wide Assessment of the Role of Untagged Copy Number Variants in Type 1 Diabetes

Manuela Zanda, Suna Onengut-Gumuscu, Neil Walker, Corina Shtir, Daniel Gallo, Chris Wallace, Deborah Smyth, John A. Todd, Matthew E. Hurles, Vincent Plagnol, Stephen S. Rich

PLOS Genetics: published May 29, 2014 | https://doi.org/10.1371/journal.pgen.1004367

PAX6 Regulates Melanogenesis in the Retinal Pigmented Epithelium through Feed-Forward Regulatory Interactions with MITF

Shaul Raviv, Kapil Bharti, Sigal Rencus-Lazar, Yamit Cohen-Tayar, Rachel Schyr, Naveh Evantal, Eran Meshorer, Alona Zilberberg, Maria Idelson, Benjamin Reubinoff, Rhonda Grebe, Rina Rosin-Arbesfeld, James Lauderdale, Gerard Lutty, Heinz Arnheiter, Ruth Ashery-Padan

PLOS Genetics: published May 29, 2014 | https://doi.org/10.1371/journal.pgen.1004360

Mosaic Epigenetic Dysregulation of Ectodermal Cells in Autism Spectrum Disorder

Esther R. Berko, Masako Suzuki, Faygel Beren, Christophe Lemetre, Christine M. Alaimo, R. Brent Calder, Karen Ballaban-Gil, Batya Gounder, Kaylee Kampf, Jill Kirschen, Shahina B. Maqbool, Zeineen Momin, David M. Reynolds, Natalie Russo, Lisa Shulman, Edyta Stasiek, Jessica Tozour, Maria Valicenti-McDermott, Shenglong Wang, Brett S. Abrahams, Joseph Hargitai, Dov Inbar, Zhengdong Zhang, Joseph D. Buxbaum, Sophie Molholm, John J. Foxe, Robert W. Marion, Adam Auton, John M. Greally

PLOS Genetics: published May 29, 2014 | https://doi.org/10.1371/journal.pgen.1004402

Rapid Evolution of PARP Genes Suggests a Broad Role for ADP-Ribosylation in Host-Virus Conflicts

Matthew D. Daugherty, Janet M. Young, Julie A. Kerns, Harmit S. Malik

PLOS Genetics: published May 29, 2014 | https://doi.org/10.1371/journal.pgen.1004403

Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway

Harry F. Heijnen, Richard van Wijk, Tamara C. Pereboom, Yvonne J. Goos, Cor W. Seinen, Brigitte A. van Oirschot, Rowie van Dooren, Marc Gastou, Rachel H. Giles, Wouter van Solinge, Taco W. Kuijpers, Hanna T. Gazda, Marc B. Bierings, Lydie Da Costa, Alyson W. MacInnes

PLOS Genetics: published May 29, 2014 | https://doi.org/10.1371/journal.pgen.1004371

The Proper Splicing of RNAi Factors Is Critical for Pericentric Heterochromatin Assembly in Fission Yeast

Scott P. Kallgren, Stuart Andrews, Xavier Tadeo, Haitong Hou, James J. Moresco, Patricia G. Tu, John R. Yates III, Peter L. Nagy, Songtao Jia

PLOS Genetics: published May 29, 2014 | https://doi.org/10.1371/journal.pgen.1004334

Discovery and Functional Annotation of SIX6 Variants in Primary Open-Angle Glaucoma

Megan Ulmer Carnes, Yangfan P. Liu, R. Rand Allingham, Benjamin T. Whigham, Shane Havens, Melanie E. Garrett, Chunyan Qiao, NEIGHBORHOOD Consortium Investigators, Nicholas Katsanis, Janey L. Wiggs, Louis R. Pasquale, Allison Ashley-Koch, Edwin C. Oh, Michael A. Hauser

PLOS Genetics: published May 29, 2014 | https://doi.org/10.1371/journal.pgen.1004372

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