March 2014

The Yeast Sks1p Kinase Signaling Network Regulates Pseudohyphal Growth and Glucose Response

Cole Johnson, Hye Kyong Kweon, Daniel Sheidy, Christian A. Shively, Dattatreya Mellacheruvu, Alexey I. Nesvizhskii, Philip C. Andrews, Anuj Kumar

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004183

Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling

Justin W. Leung, Poonam Agarwal, Marella D. Canny, Fade Gong, Aaron D. Robison, Ilya J. Finkelstein, Daniel Durocher, Kyle M. Miller

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004178

CDP-Diacylglycerol Synthetase Coordinates Cell Growth and Fat Storage through Phosphatidylinositol Metabolism and the Insulin Pathway

Yuan Liu, Wei Wang, Guanghou Shui, Xun Huang

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004172

Temperate Phages Acquire DNA from Defective Prophages by Relaxed Homologous Recombination: The Role of Rad52-Like Recombinases

Marianne De Paepe, Geoffrey Hutinet, Olivier Son, Jihane Amarir-Bouhram, Sophie Schbath, Marie-Agnès Petit

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004181

Functional Organization of a Multimodular Bacterial Chemosensory Apparatus

Audrey Moine, Rym Agrebi, Leon Espinosa, John R. Kirby, David R. Zusman, Tam Mignot, Emilia M. F. Mauriello

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004164

GC-Rich DNA Elements Enable Replication Origin Activity in the Methylotrophic Yeast Pichia pastoris

Ivan Liachko, Rachel A. Youngblood, Kyle Tsui, Kerry L. Bubb, Christine Queitsch, M. K. Raghuraman, Corey Nislow, Bonita J. Brewer, Maitreya J. Dunham

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004169

Genome-Wide DNA Methylation Analysis Predicts an Epigenetic Switch for GATA Factor Expression in Endometriosis

Matthew T. Dyson, Damian Roqueiro, Diana Monsivais, C. Mutlu Ercan, Mary Ellen Pavone, David C. Brooks, Toshiyuki Kakinuma, Masanori Ono, Nadereh Jafari, Yang Dai, Serdar E. Bulun

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004158

Cleavage Factor I Links Transcription Termination to DNA Damage Response and Genome Integrity Maintenance in Saccharomyces cerevisiae

Hélène Gaillard, Andrés Aguilera

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004203

RBPJ, the Major Transcriptional Effector of Notch Signaling, Remains Associated with Chromatin throughout Mitosis, Suggesting a Role in Mitotic Bookmarking

Robert J. Lake, Pei-Fang Tsai, Inchan Choi, Kyoung-Jae Won, Hua-Ying Fan

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004204

Epigenetic Control of Effector Gene Expression in the Plant Pathogenic Fungus Leptosphaeria maculans

Jessica L. Soyer, Mennat El Ghalid, Nicolas Glaser, Bénédicte Ollivier, Juliette Linglin, Jonathan Grandaubert, Marie-Hélène Balesdent, Lanelle R. Connolly, Michael Freitag, Thierry Rouxel, Isabelle Fudal

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004227

Co-translational Localization of an LTR-Retrotransposon RNA to the Endoplasmic Reticulum Nucleates Virus-Like Particle Assembly Sites

Jung H. Doh, Sheila Lutz, M. Joan Curcio

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004219

The First Steps of Adaptation of Escherichia coli to the Gut Are Dominated by Soft Sweeps

João Barroso-Batista, Ana Sousa, Marta Lourenço, Marie-Louise Bergman, Daniel Sobral, Jocelyne Demengeot, Karina B. Xavier, Isabel Gordo

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004182

ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma

Monisha E. Nongpiur, Chiea Chuen Khor, Hongyan Jia, Belinda K. Cornes, Li-Jia Chen, Chunyan Qiao, K. Saidas Nair, Ching-Yu Cheng, Liang Xu, Ronnie George, Do Tan, Khaled Abu-Amero, Shamira A. Perera, Mineo Ozaki, Takanori Mizoguchi, Yasuo Kurimoto, Sancy Low, Liza-Sharmini A. Tajudin, Ching-Lin Ho, Clement C. Y. Tham, Ileana Soto, Paul T. K. Chew, Hon-Tym Wong, Balekudaru Shantha, Masako Kuroda, Essam A. Osman, Guangxian Tang, Sujie Fan, Hailin Meng, Hua Wang, Bo Feng, Victor H. K. Yong, Serena M. L. Ting, Yang Li, Ya-Xing Wang, Zheng Li, Raghavan Lavanya, Ren-Yi Wu, Ying-Feng Zheng, Daniel H. Su, Seng-Chee Loon, R. Rand Allingham, Michael A. Hauser, Nagaswamy Soumittra, Vedam L. Ramprasad, Naushin Waseem, Azhany Yaakub, Kee-Seng Chia, Govindasamy Kumaramanickavel, Tina T. Wong, Alicia C. How, Tran Nguyen Bich Chau, Cameron P. Simmons, Jin-Xin Bei, Yi-Xin Zeng, Shomi S. Bhattacharya, Mingzhi Zhang, Donald T. Tan, Yik-Ying Teo, Saleh A. Al-Obeidan, Do Nhu Hon, E-Shyong Tai, Seang-Mei Saw, Paul J. Foster, Lingam Vijaya, Jost B. Jonas, Tien-Yin Wong, Simon W. M. John, Chi-Pui Pang, Eranga N. Vithana, Ningli Wang, Tin Aung

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004089

Mitogen-Activated Protein Kinase (MAPK) Pathway Regulates Branching by Remodeling Epithelial Cell Adhesion

Anneliis Ihermann-Hella, Maria Lume, Ilkka J. Miinalainen, Anniina Pirttiniemi, Yujuan Gui, Johan Peränen, Jean Charron, Mart Saarma, Frank Costantini, Satu Kuure

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004193

Final Pre-40S Maturation Depends on the Functional Integrity of the 60S Subunit Ribosomal Protein L3

Juan J. García-Gómez, Antonio Fernández-Pevida, Simon Lebaron, Iván V. Rosado, David Tollervey, Dieter Kressler, Jesús de la Cruz

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004205

Dysregulated Estrogen Receptor Signaling in the Hypothalamic-Pituitary-Ovarian Axis Leads to Ovarian Epithelial Tumorigenesis in Mice

Mary J. Laws, Athilakshmi Kannan, Sandeep Pawar, Wanda M. Haschek, Milan K. Bagchi, Indrani C. Bagchi

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004230

Cancer Evolution Is Associated with Pervasive Positive Selection on Globally Expressed Genes

Sheli L. Ostrow, Ruth Barshir, James DeGregori, Esti Yeger-Lotem, Ruth Hershberg

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004239

LILRB2 Interaction with HLA Class I Correlates with Control of HIV-1 Infection

Arman A. Bashirova, Enrique Martin-Gayo, Des C. Jones, Ying Qi, Richard Apps, Xiaojiang Gao, Patrick S. Burke, Craig J. Taylor, Jerome Rogich, Steven Wolinsky, Jay H. Bream, Priya Duggal, Shehnaz Hussain, Jeremy Martinson, Amy Weintrob, Gregory D. Kirk, Jacques Fellay, Susan P. Buchbinder, James J. Goedert, Steven G. Deeks, Florencia Pereyra, John Trowsdale, Mathias Lichterfeld, Amalio Telenti, Bruce D. Walker, Rachel L. Allen, Mary Carrington, Xu G. Yu

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004196

Gene-Based Sequencing Identifies Lipid-Influencing Variants with Ethnicity-Specific Effects in African Americans

Amy R. Bentley, Guanjie Chen, Daniel Shriner, Ayo P. Doumatey, Jie Zhou, Hanxia Huang, James C. Mullikin, Robert W. Blakesley, Nancy F. Hansen, Gerard G. Bouffard, Praveen F. Cherukuri, Baishali Maskeri, Alice C. Young, Adebowale Adeyemo, Charles N. Rotimi

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004190

Local Evolution of Seed Flotation in Arabidopsis

Susana Saez-Aguayo, Corinne Rondeau-Mouro, Audrey Macquet, Ilkka Kronholm, Marie-Christine Ralet, Adeline Berger, Christine Sallé, Damien Poulain, Fabienne Granier, Lucy Botran, Olivier Loudet, Juliette de Meaux, Annie Marion-Poll, Helen M. North

PLOS Genetics: published March 13, 2014 | https://doi.org/10.1371/journal.pgen.1004221

Genome-Wide Analysis of SREBP1 Activity around the Clock Reveals Its Combined Dependency on Nutrient and Circadian Signals

Federica Gilardi, Eugenia Migliavacca, Aurélien Naldi, Michaël Baruchet, Donatella Canella, Gwendal Le Martelot, Nicolas Guex, Béatrice Desvergne, the CycliX Consortium

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004155

Bacterial Regulon Evolution: Distinct Responses and Roles for the Identical OmpR Proteins of Salmonella Typhimurium and Escherichia coli in the Acid Stress Response

Heather J. Quinn, Andrew D. S. Cameron, Charles J. Dorman

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004215

The Rate of Nonallelic Homologous Recombination in Males Is Highly Variable, Correlated between Monozygotic Twins and Independent of Age

Jacqueline A. L. MacArthur, Timothy D. Spector, Sarah J. Lindsay, Massimo Mangino, Raj Gill, Kerrin S. Small, Matthew E. Hurles

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004195

An ER Complex of ODR-4 and ODR-8/Ufm1 Specific Protease 2 Promotes GPCR Maturation by a Ufm1-Independent Mechanism

Changchun Chen, Eisuke Itakura, Katherine P. Weber, Ramanujan S. Hegde, Mario de Bono

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004082

Noise Genetics: Inferring Protein Function by Correlating Phenotype with Protein Levels and Localization in Individual Human Cells

Shlomit Farkash-Amar, Anat Zimmer, Eran Eden, Ariel Cohen, Naama Geva-Zatorsky, Lydia Cohen, Ron Milo, Alex Sigal, Tamar Danon, Uri Alon

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004176

Genetic Basis of Metabolome Variation in Yeast

Jeffrey S. Breunig, Sean R. Hackett, Joshua D. Rabinowitz, Leonid Kruglyak

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004142

DNA Dynamics during Early Double-Strand Break Processing Revealed by Non-Intrusive Imaging of Living Cells

Hicham Saad, Franck Gallardo, Mathieu Dalvai, Nicolas Tanguy-le-Gac, David Lane, Kerstin Bystricky

PLOS Genetics: published March 13, 2014 | https://doi.org/10.1371/journal.pgen.1004187

The Functional Consequences of Variation in Transcription Factor Binding

Darren A. Cusanovich, Bryan Pavlovic, Jonathan K. Pritchard, Yoav Gilad

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004226

Genomic View of Bipolar Disorder Revealed by Whole Genome Sequencing in a Genetic Isolate

Benjamin Georgi, David Craig, Rachel L. Kember, Wencheng Liu, Ingrid Lindquist, Sara Nasser, Christopher Brown, Janice A. Egeland, Steven M. Paul, Maja Bućan

PLOS Genetics: published March 13, 2014 | https://doi.org/10.1371/journal.pgen.1004229

An Interspecific Fungal Hybrid Reveals Cross-Kingdom Rules for Allopolyploid Gene Expression Patterns

Murray P. Cox, Ting Dong, GengGeng Shen, Yogesh Dalvi, D. Barry Scott, Austen R. D. Ganley

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004180

Determinants beyond Both Complementarity and Cleavage Govern MicroR159 Efficacy in Arabidopsis

Junyan Li, Marlene Reichel, Anthony A. Millar

PLOS Genetics: published March 13, 2014 | https://doi.org/10.1371/journal.pgen.1004232

Genetic Dissection of Photoreceptor Subtype Specification by the Drosophila melanogaster Zinc Finger Proteins Elbow and No ocelli

Mathias F. Wernet, Kerstin M. Meier, Franziska Baumann-Klausener, Ruslan Dorfman, Ulrich Weihe, Thomas Labhart, Claude Desplan

PLOS Genetics: published March 13, 2014 | https://doi.org/10.1371/journal.pgen.1004210

Lsd1 Restricts the Number of Germline Stem Cells by Regulating Multiple Targets in Escort Cells

Susan Eliazer, Victor Palacios, Zhaohui Wang, Rahul K. Kollipara, Ralf Kittler, Michael Buszczak

PLOS Genetics: published March 13, 2014 | https://doi.org/10.1371/journal.pgen.1004200

Telomere Shortening Unrelated to Smoking, Body Weight, Physical Activity, and Alcohol Intake: 4,576 General Population Individuals with Repeat Measurements 10 Years Apart

Maren Weischer, Stig E. Bojesen, Børge G. Nordestgaard

PLOS Genetics: published March 13, 2014 | https://doi.org/10.1371/journal.pgen.1004191

The ABI4-Induced Arabidopsis ANAC060 Transcription Factor Attenuates ABA Signaling and Renders Seedlings Sugar Insensitive when Present in the Nucleus

Ping Li, Hua Zhou, Xiaoliang Shi, Bo Yu, Yan Zhou, Suli Chen, Yufeng Wang, Yu Peng, Rhonda C. Meyer, Sjef C. Smeekens, Sheng Teng

PLOS Genetics: published March 13, 2014 | https://doi.org/10.1371/journal.pgen.1004213

The Drosophila melanogaster Phospholipid Flippase dATP8B Is Required for Odorant Receptor Function

Yu-Chi Liu, Michelle W. Pearce, Takahiro Honda, Travis K. Johnson, Sandhya Charlu, Kavita R. Sharma, Mays Imad, Richard E. Burke, Konrad E. Zinsmaier, Anandasankar Ray, Anupama Dahanukar, Marien de Bruyne, Coral G. Warr

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004209

An Epigenetic Signature in Peripheral Blood Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy

Yun Li, Jason A. Chen, Renee L. Sears, Fuying Gao, Eric D. Klein, Anna Karydas, Michael D. Geschwind, Howard J. Rosen, Adam L. Boxer, Weilong Guo, Matteo Pellegrini, Steve Horvath, Bruce L. Miller, Daniel H. Geschwind, Giovanni Coppola

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004211

DWARF TILLER1, a WUSCHEL-Related Homeobox Transcription Factor, Is Required for Tiller Growth in Rice

Wenfei Wang, Gang Li, Jun Zhao, Huangwei Chu, Wenhui Lin, Dabing Zhang, Zhiyong Wang, Wanqi Liang

PLOS Genetics: published March 13, 2014 | https://doi.org/10.1371/journal.pgen.1004154

Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

Tasnim Dayeh, Petr Volkov, Sofia Salö, Elin Hall, Emma Nilsson, Anders H. Olsson, Clare L. Kirkpatrick, Claes B. Wollheim, Lena Eliasson, Tina Rönn, Karl Bacos, Charlotte Ling

PLOS Genetics: published March 6, 2014 | https://doi.org/10.1371/journal.pgen.1004160

Genetic Determinants Influencing Human Serum Metabolome among African Americans

Bing Yu, Yan Zheng, Danny Alexander, Alanna C. Morrison, Josef Coresh, Eric Boerwinkle

PLOS Genetics: published March 13, 2014 | https://doi.org/10.1371/journal.pgen.1004212

CYP6 P450 Enzymes and ACE-1 Duplication Produce Extreme and Multiple Insecticide Resistance in the Malaria Mosquito Anopheles gambiae

Constant V. Edi, Luc Djogbénou, Adam M. Jenkins, Kimberly Regna, Marc A. T. Muskavitch, Rodolphe Poupardin, Christopher M. Jones, John Essandoh, Guillaume K. Kétoh, Mark J. I. Paine, Benjamin G. Koudou, Martin J. Donnelly, Hilary Ranson, David Weetman

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004236

Suicidal Autointegration of Sleeping Beauty and piggyBac Transposons in Eukaryotic Cells

Yongming Wang, Jichang Wang, Anatharam Devaraj, Manvendra Singh, Ana Jimenez Orgaz, Jia-Xuan Chen, Matthias Selbach, Zoltán Ivics, Zsuzsanna Izsvák

PLOS Genetics: published March 13, 2014 | https://doi.org/10.1371/journal.pgen.1004103

Sex Chromosome Turnover Contributes to Genomic Divergence between Incipient Stickleback Species

Kohta Yoshida, Takashi Makino, Katsushi Yamaguchi, Shuji Shigenobu, Mitsuyasu Hasebe, Masakado Kawata, Manabu Kume, Seiichi Mori, Catherine L. Peichel, Atsushi Toyoda, Asao Fujiyama, Jun Kitano

PLOS Genetics: published March 13, 2014 | https://doi.org/10.1371/journal.pgen.1004223

Chromatin Targeting Signals, Nucleosome Positioning Mechanism and Non-Coding RNA-Mediated Regulation of the Chromatin Remodeling Complex NoRC

Laura Manelyte, Ralf Strohner, Thomas Gross, Gernot Längst

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004157

DUF1220 Dosage Is Linearly Associated with Increasing Severity of the Three Primary Symptoms of Autism

Jonathan M. Davis, Veronica B. Searles, Nathan Anderson, Jonathon Keeney, Laura Dumas, James M. Sikela

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004241

The Hmr and Lhr Hybrid Incompatibility Genes Suppress a Broad Range of Heterochromatic Repeats

P. R. V. Satyaki, Tawny N. Cuykendall, Kevin H-C. Wei, Nicholas J. Brideau, Hojoong Kwak, S. Aruna, Patrick M. Ferree, Shuqing Ji, Daniel A. Barbash

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004240

Sugar and Chromosome Stability: Clastogenic Effects of Sugars in Vitamin B6-Deficient Cells

Antonio Marzio, Chiara Merigliano, Maurizio Gatti, Fiammetta Vernì

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004199

Modeling 3D Facial Shape from DNA

Peter Claes, Denise K. Liberton, Katleen Daniels, Kerri Matthes Rosana, Ellen E. Quillen, Laurel N. Pearson, Brian McEvoy, Marc Bauchet, Arslan A. Zaidi, Wei Yao, Hua Tang, Gregory S. Barsh, Devin M. Absher, David A. Puts, Jorge Rocha, Sandra Beleza, Rinaldo W. Pereira, Gareth Baynam, Paul Suetens, Dirk Vandermeulen, Jennifer K. Wagner, James S. Boster, Mark D. Shriver

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004224

The bHLH Factors Extramacrochaetae and Daughterless Control Cell Cycle in Drosophila Imaginal Discs through the Transcriptional Regulation of the cdc25 Phosphatase string

Irene Andrade-Zapata, Antonio Baonza

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004233

FAK Acts as a Suppressor of RTK-MAP Kinase Signalling in Drosophila melanogaster Epithelia and Human Cancer Cells

Juan Pablo Macagno, Jesica Diaz Vera, Yachuan Yu, Iain MacPherson, Emma Sandilands, Ruth Palmer, Jim C. Norman, Margaret Frame, Marcos Vidal

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004262

Validation and Genotyping of Multiple Human Polymorphic Inversions Mediated by Inverted Repeats Reveals a High Degree of Recurrence

Cristina Aguado, Magdalena Gayà-Vidal, Sergi Villatoro, Meritxell Oliva, David Izquierdo, Carla Giner-Delgado, Víctor Montalvo, Judit García-González, Alexander Martínez-Fundichely, Laia Capilla, Aurora Ruiz-Herrera, Xavier Estivill, Marta Puig, Mario Cáceres

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004208

Asymmetry in Family History Implicates Nonstandard Genetic Mechanisms: Application to the Genetics of Breast Cancer

Clarice R. Weinberg, Min Shi, Lisa A. DeRoo, Jack A. Taylor, Dale P. Sandler, David M. Umbach

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004174

The Kil Peptide of Bacteriophage λ Blocks Escherichia coli Cytokinesis via ZipA-Dependent Inhibition of FtsZ Assembly

Daniel P. Haeusser, Marina Hoashi, Anna Weaver, Nathan Brown, James Pan, James A. Sawitzke, Lynn C. Thomason, Donald L. Court, William Margolin

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004217

Integrating Multiple Genomic Data to Predict Disease-Causing Nonsynonymous Single Nucleotide Variants in Exome Sequencing Studies

Jiaxin Wu, Yanda Li, Rui Jiang

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004237

Drosophila Pheromone-Sensing Neurons Expressing the ppk25 Ion Channel Subunit Stimulate Male Courtship and Female Receptivity

Vinoy Vijayan, Rob Thistle, Tong Liu, Elena Starostina, Claudio W. Pikielny

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004238

Genome-Wide Meta-Analysis of Homocysteine and Methionine Metabolism Identifies Five One Carbon Metabolism Loci and a Novel Association of ALDH1L1 with Ischemic Stroke

Stephen R. Williams, Qiong Yang, Fang Chen, Xuan Liu, Keith L. Keene, Paul Jacques, Wei-Min Chen, Galit Weinstein, Fang-Chi Hsu, Alexa Beiser, Liewei Wang, Ebony Bookman, Kimberly F. Doheny, Philip A. Wolf, Michelle Zilka, Jacob Selhub, Sarah Nelson, Stephanie M. Gogarten, Bradford B. Worrall, Sudha Seshadri, Michèle M. Sale, the Genomics and Randomized Trials Network, the Framingham Heart Study

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004214

Photoactivated UVR8-COP1 Module Determines Photomorphogenic UV-B Signaling Output in Arabidopsis

Xi Huang, Panyu Yang, Xinhao Ouyang, Liangbi Chen, Xing Wang Deng

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004218

A Combination of Activation and Repression by a Colinear Hox Code Controls Forelimb-Restricted Expression of Tbx5 and Reveals Hox Protein Specificity

Satoko Nishimoto, Carolina Minguillon, Sophie Wood, Malcolm P. O. Logan

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004245

A Multi-Trait, Meta-analysis for Detecting Pleiotropic Polymorphisms for Stature, Fatness and Reproduction in Beef Cattle

Sunduimijid Bolormaa, Jennie E. Pryce, Antonio Reverter, Yuandan Zhang, William Barendse, Kathryn Kemper, Bruce Tier, Keith Savin, Ben J. Hayes, Michael E. Goddard

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004198

Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation

Clint L. Miller, Ulrike Haas, Roxanne Diaz, Nicholas J. Leeper, Ramendra K. Kundu, Bhagat Patlolla, Themistocles L. Assimes, Frank J. Kaiser, Ljubica Perisic, Ulf Hedin, Lars Maegdefessel, Heribert Schunkert, Jeanette Erdmann, Thomas Quertermous, Georg Sczakiel

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004263

An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology

Diana Andrea Fernandes de Abreu, Antonio Caballero, Pascal Fardel, Nicholas Stroustrup, Zhunan Chen, KyungHwa Lee, William D. Keyes, Zachary M. Nash, Isaac F. López-Moyado, Federico Vaggi, Astrid Cornils, Martin Regenass, Anca Neagu, Ivan Ostojic, Chang Liu, Yongmin Cho, Deniz Sifoglu, Yu Shen, Walter Fontana, Hang Lu, Attila Csikasz-Nagy, Coleen T. Murphy, Adam Antebi, Eric Blanc, Javier Apfeld, Yun Zhang, Joy Alcedo, QueeLim Ch'ng

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004225

Identification of Interphase Functions for the NIMA Kinase Involving Microtubules and the ESCRT Pathway

Meera Govindaraghavan, Sarah Lea McGuire Anglin, Kuo-Fang Shen, Nandini Shukla, Colin P. De Souza, Stephen A. Osmani

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004248

CDKN2D-WDFY2 Is a Cancer-Specific Fusion Gene Recurrent in High-Grade Serous Ovarian Carcinoma

Kalpana Kannan, Cristian Coarfa, Kimal Rajapakshe, Shannon M. Hawkins, Martin M. Matzuk, Aleksandar Milosavljevic, Laising Yen

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004216

The Membrane-Associated Transcription Factor NAC089 Controls ER-Stress-Induced Programmed Cell Death in Plants

Zheng-Ting Yang, Mei-Jing Wang, Ling Sun, Sun-Jie Lu, Dong-Ling Bi, Le Sun, Ze-Ting Song, Shuang-Shuang Zhang, Shun-Fan Zhou, Jian-Xiang Liu

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004243

Selection of Orphan Rhs Toxin Expression in Evolved Salmonella enterica Serovar Typhimurium

Sanna Koskiniemi, Fernando Garza-Sánchez, Linus Sandegren, Julia S. Webb, Bruce A. Braaten, Stephen J. Poole, Dan I. Andersson, Christopher S. Hayes, David A. Low

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004255

Heterozygous De Novo and Inherited Mutations in the Smooth Muscle Actin (ACTG2) Gene Underlie Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome

Michael F. Wangler, Claudia Gonzaga-Jauregui, Tomasz Gambin, Samantha Penney, Timothy Moss, Atul Chopra, Frank J. Probst, Fan Xia, Yaping Yang, Steven Werlin, Ieva Eglite, Liene Kornejeva, Carlos A. Bacino, Dustin Baldridge, Jeff Neul, Efrat Lev Lehman, Austin Larson, Joke Beuten, Donna M. Muzny, Shalini Jhangiani, Baylor-Hopkins Center for Mendelian Genomics, Richard A. Gibbs, James R. Lupski, Arthur Beaudet

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004258

Dying Cells Protect Survivors from Radiation-Induced Cell Death in Drosophila

Amber Bilak, Lyle Uyetake, Tin Tin Su

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004220

Parent-of-Origin Effects Implicate Epigenetic Regulation of Experimental Autoimmune Encephalomyelitis and Identify Imprinted Dlk1 as a Novel Risk Gene

Pernilla Stridh, Sabrina Ruhrmann, Petra Bergman, Mélanie Thessén Hedreul, Sevasti Flytzani, Amennai Daniel Beyeen, Alan Gillett, Nina Krivosija, Johan Öckinger, Anne C. Ferguson-Smith, Maja Jagodic

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004265

Genetic Diversity in the Interference Selection Limit

Benjamin H. Good, Aleksandra M. Walczak, Richard A. Neher, Michael M. Desai

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004222

An Evolutionary Analysis of Antigen Processing and Presentation across Different Timescales Reveals Pervasive Selection

Diego Forni, Rachele Cagliani, Claudia Tresoldi, Uberto Pozzoli, Luca De Gioia, Giulia Filippi, Stefania Riva, Giorgia Menozzi, Marta Colleoni, Mara Biasin, Sergio Lo Caputo, Francesco Mazzotta, Giacomo P. Comi, Nereo Bresolin, Mario Clerici, Manuela Sironi

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004189

Worldwide Patterns of Ancestry, Divergence, and Admixture in Domesticated Cattle

Jared E. Decker, Stephanie D. McKay, Megan M. Rolf, JaeWoo Kim, Antonio Molina Alcalá, Tad S. Sonstegard, Olivier Hanotte, Anders Götherström, Christopher M. Seabury, Lisa Praharani, Masroor Ellahi Babar, Luciana Correia de Almeida Regitano, Mehmet Ali Yildiz, Michael P. Heaton, Wan-Sheng Liu, Chu-Zhao Lei, James M. Reecy, Muhammad Saif-Ur-Rehman, Robert D. Schnabel, Jeremy F. Taylor

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004254

Changes in Colorectal Carcinoma Genomes under Anti-EGFR Therapy Identified by Whole-Genome Plasma DNA Sequencing

Sumitra Mohan, Ellen Heitzer, Peter Ulz, Ingrid Lafer, Sigurd Lax, Martina Auer, Martin Pichler, Armin Gerger, Florian Eisner, Gerald Hoefler, Thomas Bauernhofer, Jochen B. Geigl, Michael R. Speicher

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004271

TBX3 Regulates Splicing In Vivo: A Novel Molecular Mechanism for Ulnar-Mammary Syndrome

Pavan Kumar P., Sarah Franklin, Uchenna Emechebe, Hao Hu, Barry Moore, Chris Lehman, Mark Yandell, Anne M. Moon

PLOS Genetics: published March 27, 2014 | https://doi.org/10.1371/journal.pgen.1004247

Comparative Genomic Analysis of N₂-Fixing and Non-N₂-Fixing Paenibacillus spp.: Organization, Evolution and Expression of the Nitrogen Fixation Genes

Jian-Bo Xie, Zhenglin Du, Lanqing Bai, Changfu Tian, Yunzhi Zhang, Jiu-Yan Xie, Tianshu Wang, Xiaomeng Liu, Xi Chen, Qi Cheng, Sanfeng Chen, Jilun Li

PLOS Genetics: published March 20, 2014 | https://doi.org/10.1371/journal.pgen.1004231

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MAPK activity in pseudostratified renal epithelium, which exhibits different cell cycle phases in one layer of cells.

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