April 2013

Six Homeoproteins Directly Activate Myod Expression in the Gene Regulatory Networks That Control Early Myogenesis

Frédéric Relaix, Josiane Demignon, Christine Laclef, Julien Pujol, Marc Santolini, Claire Niro, Mounia Lagha, Didier Rocancourt, Margaret Buckingham, Pascal Maire

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003425

Tissue Homeostasis in the Wing Disc of Drosophila melanogaster: Immediate Response to Massive Damage during Development

Salvador C. Herrera, Raquel Martín, Ginés Morata

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003446

All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs

Andrew J. Schork, Wesley K. Thompson, Phillip Pham, Ali Torkamani, J. Cooper Roddey, Patrick F. Sullivan, John R. Kelsoe, Michael C. O'Donovan, Helena Furberg, The Tobacco and Genetics Consortium, The Bipolar Disorder Psychiatric Genomics Consortium, The Schizophrenia Psychiatric Genomics Consortium, Nicholas J. Schork, Ole A. Andreassen, Anders M. Dale

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003449

Signatures of Diversifying Selection in European Pig Breeds

Samantha Wilkinson, Zen H. Lu, Hendrik-Jan Megens, Alan L. Archibald, Chris Haley, Ian J. Jackson, Martien A. M. Groenen, Richard P. M. A. Crooijmans, Rob Ogden, Pamela Wiener

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003453

Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate

Ole A. Andreassen, Wesley K. Thompson, Andrew J. Schork, Stephan Ripke, Morten Mattingsdal, John R. Kelsoe, Kenneth S. Kendler, Michael C. O'Donovan, Dan Rujescu, Thomas Werge, Pamela Sklar, The Psychiatric Genomics Consortium (PGC), Bipolar Disorder and Schizophrenia Working Groups, J. Cooper Roddey, Chi-Hua Chen, Linda McEvoy, Rahul S. Desikan, Srdjan Djurovic, Anders M. Dale

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003455

SNF5 Is an Essential Executor of Epigenetic Regulation during Differentiation

Jueng Soo You, Daniel D. De Carvalho, Chao Dai, Minmin Liu, Kurinji Pandiyan, Xianghong J. Zhou, Gangning Liang, Peter A. Jones

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003459

Breakpoint Analysis of Transcriptional and Genomic Profiles Uncovers Novel Gene Fusions Spanning Multiple Human Cancer Types

Craig P. Giacomini, Steven Sun, Sushama Varma, A. Hunter Shain, Marilyn M. Giacomini, Jay Balagtas, Robert T. Sweeney, Everett Lai, Catherine A. Del Vecchio, Andrew D. Forster, Nicole Clarke, Kelli D. Montgomery, Shirley Zhu, Albert J. Wong, Matt van de Rijn, Robert B. West, Jonathan R. Pollack

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003464

Genetic Requirements for Signaling from an Autoactive Plant NB-LRR Intracellular Innate Immune Receptor

Melinda Roberts, Saijun Tang, Anna Stallmann, Jeffery L. Dangl, Vera Bonardi

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003465

Tbx2 Terminates Shh/Fgf Signaling in the Developing Mouse Limb Bud by Direct Repression of Gremlin1

Henner F. Farin, Timo H-W. Lüdtke, Martina K. Schmidt, Susann Placzko, Karin Schuster-Gossler, Marianne Petry, Vincent M. Christoffels, Andreas Kispert

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003467

Genetic and Biochemical Assays Reveal a Key Role for Replication Restart Proteins in Group II Intron Retrohoming

Jun Yao, David M. Truong, Alan M. Lambowitz

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003469

Transposable Elements Are Major Contributors to the Origin, Diversification, and Regulation of Vertebrate Long Noncoding RNAs

Aurélie Kapusta, Zev Kronenberg, Vincent J. Lynch, Xiaoyu Zhuo, LeeAnn Ramsay, Guillaume Bourque, Mark Yandell, Cédric Feschotte

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003470

The Tissue-Specific RNA Binding Protein T-STAR Controls Regional Splicing Patterns of Neurexin Pre-mRNAs in the Brain

Ingrid Ehrmann, Caroline Dalgliesh, Yilei Liu, Marina Danilenko, Moira Crosier, Lynn Overman, Helen M. Arthur, Susan Lindsay, Gavin J. Clowry, Julian P. Venables, Philippe Fort, David J. Elliott

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003474

The Hourglass and the Early Conservation Models—Co-Existing Patterns of Developmental Constraints in Vertebrates

Barbara Piasecka, Paweł Lichocki, Sébastien Moretti, Sven Bergmann, Marc Robinson-Rechavi

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003476

Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants

Giovanni Esposito, Melissa Vos, Sven Vilain, Jef Swerts, Jorge De Sousa Valadas, Stefanie Van Meensel, Onno Schaap, Patrik Verstreken

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003478

Genome-Wide Association Studies Identify Two Novel BMP15 Mutations Responsible for an Atypical Hyperprolificacy Phenotype in Sheep

Julie Demars, Stéphane Fabre, Julien Sarry, Raffaella Rossetti, Hélène Gilbert, Luca Persani, Gwenola Tosser-Klopp, Philippe Mulsant, Zuzanna Nowak, Wioleta Drobik, Elzbieta Martyniuk, Loys Bodin

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003482

The Genome Organization of Thermotoga maritima Reflects Its Lifestyle

Haythem Latif, Joshua A. Lerman, Vasiliy A. Portnoy, Yekaterina Tarasova, Harish Nagarajan, Alexandra C. Schrimpe-Rutledge, Richard D. Smith, Joshua N. Adkins, Dae-Hee Lee, Yu Qiu, Karsten Zengler

PLOS Genetics: published April 25, 2013 | https://doi.org/10.1371/journal.pgen.1003485

TIP48/Reptin and H2A.Z Requirement for Initiating Chromatin Remodeling in Estrogen-Activated Transcription

Mathieu Dalvai, Laurence Fleury, Luca Bellucci, Silvia Kocanova, Kerstin Bystricky

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003387

ATP-Dependent Chromatin Remodeling by Cockayne Syndrome Protein B and NAP1-Like Histone Chaperones Is Required for Efficient Transcription-Coupled DNA Repair

Iltaeg Cho, Pei-Fang Tsai, Robert J. Lake, Asjad Basheer, Hua-Ying Fan

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003407

Disruption of TTDA Results in Complete Nucleotide Excision Repair Deficiency and Embryonic Lethality

Arjan F. Theil, Julie Nonnekens, Barbara Steurer, Pierre-Olivier Mari, Jan de Wit, Charlène Lemaitre, Jurgen A. Marteijn, Anja Raams, Alex Maas, Marcel Vermeij, Jeroen Essers, Jan H. J. Hoeijmakers, Giuseppina Giglia-Mari, Wim Vermeulen

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003431

Rod Monochromacy and the Coevolution of Cetacean Retinal Opsins

Robert W. Meredith, John Gatesy, Christopher A. Emerling, Vincent M. York, Mark S. Springer

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003432

Insulators Target Active Genes to Transcription Factories and Polycomb-Repressed Genes to Polycomb Bodies

Hua-Bing Li, Katsuhito Ohno, Hongxing Gui, Vincenzo Pirrotta

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003436

Mouse Oocyte Methylomes at Base Resolution Reveal Genome-Wide Accumulation of Non-CpG Methylation and Role of DNA Methyltransferases

Kenjiro Shirane, Hidehiro Toh, Hisato Kobayashi, Fumihito Miura, Hatsune Chiba, Takashi Ito, Tomohiro Kono, Hiroyuki Sasaki

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003439

Sex-Differential Selection and the Evolution of X Inactivation Strategies

Tim Connallon, Andrew G. Clark

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003440

Smaug/SAMD4A Restores Translational Activity of CUGBP1 and Suppresses CUG-Induced Myopathy

Maria de Haro, Ismael Al-Ramahi, Karlie R. Jones, Jerrah K. Holth, Lubov T. Timchenko, Juan Botas

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003445

The Chromosomal Passenger Protein Birc5b Organizes Microfilaments and Germ Plasm in the Zebrafish Embryo

Sreelaja Nair, Florence Marlow, Elliott Abrams, Lee Kapp, Mary C. Mullins, Francisco Pelegri

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003448

Sensory Neuron-Derived Eph Regulates Glomerular Arbors and Modulatory Function of a Central Serotonergic Neuron

Ajeet Pratap Singh, Rudra Nayan Das, Gururaj Rao, Aman Aggarwal, Soeren Diegelmann, Jan Felix Evers, Hrishikesh Karandikar, Matthias Landgraf, Veronica Rodrigues, K. VijayRaghavan

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003452

Cytotoxic Chromosomal Targeting by CRISPR/Cas Systems Can Reshape Bacterial Genomes and Expel or Remodel Pathogenicity Islands

Reuben B. Vercoe, James T. Chang, Ron L. Dy, Corinda Taylor, Tamzin Gristwood, James S. Clulow, Corinna Richter, Rita Przybilski, Andrew R. Pitman, Peter C. Fineran

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003454

Comprehensive Assignment of Roles for Salmonella Typhimurium Genes in Intestinal Colonization of Food-Producing Animals

Roy R. Chaudhuri, Eirwen Morgan, Sarah E. Peters, Stephen J. Pleasance, Debra L. Hudson, Holly M. Davies, Jinhong Wang, Pauline M. van Diemen, Anthony M. Buckley, Alison J. Bowen, Gillian D. Pullinger, Daniel J. Turner, Gemma C. Langridge, A. Keith Turner, Julian Parkhill, Ian G. Charles, Duncan J. Maskell, Mark P. Stevens

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003456

Dialects of the DNA Uptake Sequence in Neisseriaceae

Stephan A. Frye, Mariann Nilsen, Tone Tønjum, Ole Herman Ambur

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003458

The Histone Demethylase Jarid1b Ensures Faithful Mouse Development by Protecting Developmental Genes from Aberrant H3K4me3

Mareike Albert, Sandra U. Schmitz, Susanne M. Kooistra, Martina Malatesta, Cristina Morales Torres, Jens C. Rekling, Jens V. Johansen, Iratxe Abarrategui, Kristian Helin

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003461

Functional Dissection of the Drosophila melanogaster Condensin Subunit Cap-G Reveals Its Exclusive Association with Condensin I

Sabine Herzog, Sonal Nagarkar Jaiswal, Evelin Urban, Anna Riemer, Sina Fischer, Stefan K. Heidmann

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003463

Identification of a Tissue-Selective Heat Shock Response Regulatory Network

Eric Guisbert, Daniel M. Czyz, Klaus Richter, Patrick D. McMullen, Richard I. Morimoto

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003466

Neutral Genomic Microevolution of a Recently Emerged Pathogen, Salmonella enterica Serovar Agona

Zhemin Zhou, Angela McCann, Eva Litrup, Ronan Murphy, Martin Cormican, Seamus Fanning, Derek Brown, David S. Guttman, Sylvain Brisse, Mark Achtman

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003471

Scavenger Receptors Mediate the Role of SUMO and Ftz-f1 in Drosophila Steroidogenesis

Ana Talamillo, Leire Herboso, Lucia Pirone, Coralia Pérez, Monika González, Jonatan Sánchez, Ugo Mayor, Fernando Lopitz-Otsoa, Manuel S. Rodriguez, James D. Sutherland, Rosa Barrio

PLOS Genetics: published April 18, 2013 | https://doi.org/10.1371/journal.pgen.1003473

A Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest with Documented Ventricular Fibrillation

Yukiko Nakano, Kazuaki Chayama, Hidenori Ochi, Masaaki Toshishige, Yasufumi Hayashida, Daiki Miki, C. Nelson Hayes, Hidekazu Suzuki, Takehito Tokuyama, Noboru Oda, Kazuyoshi Suenari, Yuko Uchimura-Makita, Kenta Kajihara, Akinori Sairaku, Chikaaki Motoda, Mai Fujiwara, Yoshikazu Watanabe, Yukihiko Yoshida, Kimie Ohkubo, Ichiro Watanabe, Akihiko Nogami, Kanae Hasegawa, Hiroshi Watanabe, Naoto Endo, Takeshi Aiba, Wataru Shimizu, Seiko Ohno, Minoru Horie, Koji Arihiro, Satoshi Tashiro, Naomasa Makita, Yasuki Kihara

PLOS Genetics: published April 11, 2013 | https://doi.org/10.1371/journal.pgen.1003364

Mutations in LRRC50 Predispose Zebrafish and Humans to Seminomas

Sander G. Basten, Erica E. Davis, Ad J. M. Gillis, Ellen van Rooijen, Hans Stoop, Nikolina Babala, Ive Logister, Zachary G. Heath, Trudy N. Jonges, Nicholas Katsanis, Emile E. Voest, Freek J. van Eeden, Rene H. Medema, René F. Ketting, Stefan Schulte-Merker, Leendert H. J. Looijenga, Rachel H. Giles

PLOS Genetics: published April 11, 2013 | https://doi.org/10.1371/journal.pgen.1003384

Balancing Selection on a Regulatory Region Exhibiting Ancient Variation That Predates Human–Neandertal Divergence

Omer Gokcumen, Qihui Zhu, Lubbertus C. F. Mulder, Rebecca C. Iskow, Christian Austermann, Christopher D. Scharer, Towfique Raj, Jeremy M. Boss, Shamil Sunyaev, Alkes Price, Barbara Stranger, Viviana Simon, Charles Lee

PLOS Genetics: published April 11, 2013 | https://doi.org/10.1371/journal.pgen.1003404

RpoS Plays a Central Role in the SOS Induction by Sub-Lethal Aminoglycoside Concentrations in Vibrio cholerae

Zeynep Baharoglu, Evelyne Krin, Didier Mazel

PLOS Genetics: published April 11, 2013 | https://doi.org/10.1371/journal.pgen.1003421

Coordinated Cell Type–Specific Epigenetic Remodeling in Prefrontal Cortex Begins before Birth and Continues into Early Adulthood

Hennady P. Shulha, Iris Cheung, Yin Guo, Schahram Akbarian, Zhiping Weng

PLOS Genetics: published April 11, 2013 | https://doi.org/10.1371/journal.pgen.1003433

Senataxin Plays an Essential Role with DNA Damage Response Proteins in Meiotic Recombination and Gene Silencing

Olivier J. Becherel, Abrey J. Yeo, Alissa Stellati, Evelyn Y. H. Heng, John Luff, Amila M. Suraweera, Rick Woods, Jean Fleming, Dianne Carrie, Kristine McKinney, Xiaoling Xu, Chuxia Deng, Martin F. Lavin

PLOS Genetics: published April 11, 2013 | https://doi.org/10.1371/journal.pgen.1003435

Extensive Natural Epigenetic Variation at a De Novo Originated Gene

Amanda Bortolini Silveira, Charlotte Trontin, Sandra Cortijo, Joan Barau, Luiz Eduardo Vieira Del Bem, Olivier Loudet, Vincent Colot, Michel Vincentz

PLOS Genetics: published April 11, 2013 | https://doi.org/10.1371/journal.pgen.1003437

Analysis of Rare, Exonic Variation amongst Subjects with Autism Spectrum Disorders and Population Controls

Li Liu, Aniko Sabo, Benjamin M. Neale, Uma Nagaswamy, Christine Stevens, Elaine Lim, Corneliu A. Bodea, Donna Muzny, Jeffrey G. Reid, Eric Banks, Hillary Coon, Mark DePristo, Huyen Dinh, Tim Fennel, Jason Flannick, Stacey Gabriel, Kiran Garimella, Shannon Gross, Alicia Hawes, Lora Lewis, Vladimir Makarov, Jared Maguire, Irene Newsham, Ryan Poplin, Stephan Ripke, Khalid Shakir, Kaitlin E. Samocha, Yuanqing Wu, Eric Boerwinkle, Joseph D. Buxbaum, Edwin H. Cook Jr, Bernie Devlin, Gerard D. Schellenberg, James S. Sutcliffe, Mark J. Daly, Richard A. Gibbs, Kathryn Roeder

PLOS Genetics: published April 11, 2013 | https://doi.org/10.1371/journal.pgen.1003443

Reference-Free Population Genomics from Next-Generation Transcriptome Data and the Vertebrate–Invertebrate Gap

Philippe Gayral, José Melo-Ferreira, Sylvain Glémin, Nicolas Bierne, Miguel Carneiro, Benoit Nabholz, Joao M. Lourenco, Paulo C. Alves, Marion Ballenghien, Nicolas Faivre, Khalid Belkhir, Vincent Cahais, Etienne Loire, Aurélien Bernard, Nicolas Galtier

PLOS Genetics: published April 11, 2013 | https://doi.org/10.1371/journal.pgen.1003457

Continent-Wide Decoupling of Y-Chromosomal Genetic Variation from Language and Geography in Native South Americans

Lutz Roewer, Michael Nothnagel, Leonor Gusmão, Veronica Gomes, Miguel González, Daniel Corach, Andrea Sala, Evguenia Alechine, Teresinha Palha, Ney Santos, Andrea Ribeiro-dos-Santos, Maria Geppert, Sascha Willuweit, Marion Nagy, Sarah Zweynert, Miriam Baeta, Carolina Núñez, Begoña Martínez-Jarreta, Fabricio González-Andrade, Elizeu Fagundes de Carvalho, Dayse Aparecida da Silva, Juan José Builes, Daniel Turbón, Ana Maria Lopez Parra, Eduardo Arroyo-Pardo, Ulises Toscanini, Lisbeth Borjas, Claudia Barletta, Elizabeth Ewart, Sidney Santos, Michael Krawczak

PLOS Genetics: published April 11, 2013 | https://doi.org/10.1371/journal.pgen.1003460

Npc1 Acting in Neurons and Glia Is Essential for the Formation and Maintenance of CNS Myelin

Ting Yu, Andrew P. Lieberman

PLOS Genetics: published April 11, 2013 | https://doi.org/10.1371/journal.pgen.1003462

Site-Specific Phosphorylation of the DNA Damage Response Mediator Rad9 by Cyclin-Dependent Kinases Regulates Activation of Checkpoint Kinase 1

Carla Manuela Abreu, Ramesh Kumar, Danielle Hamilton, Andrew William Dawdy, Kevin Creavin, Sarah Eivers, Karen Finn, Jeremy Lynn Balsbaugh, Rosemary O'Connor, Patrick A. Kiely, Jeffrey Shabanowitz, Donald F. Hunt, Muriel Grenon, Noel Francis Lowndes

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003310

Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a Gene Cluster That Targets NF-kB

Angela Garding, Nupur Bhattacharya, Rainer Claus, Melanie Ruppel, Cordula Tschuch, Katharina Filarsky, Irina Idler, Manuela Zucknick, Maïwen Caudron-Herger, Christopher Oakes, Verena Fleig, Ioanna Keklikoglou, Danilo Allegra, Leticia Serra, Sudhir Thakurela, Vijay Tiwari, Dieter Weichenhan, Axel Benner, Bernhard Radlwimmer, Hanswalter Zentgraf, Stefan Wiemann, Karsten Rippe, Christoph Plass, Hartmut Döhner, Peter Lichter, Stephan Stilgenbauer, Daniel Mertens

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003373

Comparative Genomics of Wolbachia and the Bacterial Species Concept

Kirsten Maren Ellegaard, Lisa Klasson, Kristina Näslund, Kostas Bourtzis, Siv G. E. Andersson

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003381

Genetic and Genomic Architecture of the Evolution of Resistance to Antifungal Drug Combinations

Jessica A. Hill, Ron Ammar, Dax Torti, Corey Nislow, Leah E. Cowen

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003390

Bisphenol A Exposure Disrupts Genomic Imprinting in the Mouse

Martha Susiarjo, Isaac Sasson, Clementina Mesaros, Marisa S. Bartolomei

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003401

Iron-Responsive miR-485-3p Regulates Cellular Iron Homeostasis by Targeting Ferroportin

Carolyn Sangokoya, Jennifer F. Doss, Jen-Tsan Chi

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003408

Rtt109 Prevents Hyper-Amplification of Ribosomal RNA Genes through Histone Modification in Budding Yeast

Satoru Ide, Kimiko Saka, Takehiko Kobayashi

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003410

Drosophila DJ-1 Decreases Neural Sensitivity to Stress by Negatively Regulating Daxx-Like Protein through dFOXO

Soojin Hwang, Saera Song, Yoon Ki Hong, Gahee Choi, Yoon Seok Suh, Seung Yeop Han, Minjung Lee, Seung Hwan Park, Jang Ho Lee, Soojin Lee, Se Min Bang, Yuji Jeong, Won-Ju Chung, Im-Soon Lee, Gilsang Jeong, Jongkyeong Chung, Kyoung Sang Cho

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003412

Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1

Jennifer A. Calvo, Catherine A. Moroski-Erkul, Annabelle Lake, Lindsey W. Eichinger, Dharini Shah, Iny Jhun, Prajit Limsirichai, Roderick T. Bronson, David C. Christiani, Lisiane B. Meira, Leona D. Samson

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003413

Intrinsic Epigenetic Regulation of the D4Z4 Macrosatellite Repeat in a Transgenic Mouse Model for FSHD

Yvonne D. Krom, Peter E. Thijssen, Janet M. Young, Bianca den Hamer, Judit Balog, Zizhen Yao, Lisa Maves, Lauren Snider, Paul Knopp, Peter S. Zammit, Tonnie Rijkers, Baziel G. M. van Engelen, George W. Padberg, Rune R. Frants, Rabi Tawil, Stephen J. Tapscott, Silvère M. van der Maarel

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003415

Differential Association of the Conserved SUMO Ligase Zip3 with Meiotic Double-Strand Break Sites Reveals Regional Variations in the Outcome of Meiotic Recombination

Maria-Elisabetta Serrentino, Emmanuel Chaplais, Vérane Sommermeyer, Valérie Borde

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003416

Phosphorylation-Coupled Proteolysis of the Transcription Factor MYC2 Is Important for Jasmonate-Signaled Plant Immunity

Qingzhe Zhai, Liuhua Yan, Dan Tan, Rong Chen, Jiaqiang Sun, Liyan Gao, Meng-Qiu Dong, Yingchun Wang, Chuanyou Li

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003422

Asynchronous Replication, Mono-Allelic Expression, and Long Range Cis-Effects of ASAR6

Nathan Donley, Eric P. Stoffregen, Leslie Smith, Christina Montagna, Mathew J. Thayer

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003423

The Environment Affects Epistatic Interactions to Alter the Topology of an Empirical Fitness Landscape

Kenneth M. Flynn, Tim F. Cooper, Francisco B-G. Moore, Vaughn S. Cooper

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003426

Evolution after Introduction of a Novel Metabolic Pathway Consistently Leads to Restoration of Wild-Type Physiology

Sean Michael Carroll, Christopher J. Marx

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003427

An Essential Role for Zygotic Expression in the Pre-Cellular Drosophila Embryo

Zehra Ali-Murthy, Susan E. Lott, Michael B. Eisen, Thomas B. Kornberg

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003428

DNA Double-Strand Breaks Coupled with PARP1 and HNRNPA2B1 Binding Sites Flank Coordinately Expressed Domains in Human Chromosomes

Nickolai A. Tchurikov, Olga V. Kretova, Daria M. Fedoseeva, Dmitri V. Sosin, Sergei A. Grachev, Marina V. Serebraykova, Svetlana A. Romanenko, Nadezhda V. Vorobieva, Yuri V. Kravatsky

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003429

High-Resolution Mapping of Spontaneous Mitotic Recombination Hotspots on the 1.1 Mb Arm of Yeast Chromosome IV

Jordan St. Charles, Thomas D. Petes

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003434

Mondo/ChREBP-Mlx-Regulated Transcriptional Network Is Essential for Dietary Sugar Tolerance in Drosophila

Essi Havula, Mari Teesalu, Tuulia Hyötyläinen, Heini Seppälä, Kiran Hasygar, Petri Auvinen, Matej Orešič, Thomas Sandmann, Ville Hietakangas

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003438

Identification of Rtl1, a Retrotransposon-Derived Imprinted Gene, as a Novel Driver of Hepatocarcinogenesis

Jesse D. Riordan, Vincent W. Keng, Barbara R. Tschida, Todd E. Scheetz, Jason B. Bell, Kelly M. Podetz-Pedersen, Catherine D. Moser, Neal G. Copeland, Nancy A. Jenkins, Lewis R. Roberts, David A. Largaespada, Adam J. Dupuy

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003441

Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

Ricardo C. Ferreira, Daniel F. Freitag, Antony J. Cutler, Joanna M. M. Howson, Daniel B. Rainbow, Deborah J. Smyth, Stephen Kaptoge, Pamela Clarke, Charlotte Boreham, Richard M. Coulson, Marcin L. Pekalski, Wei-Min Chen, Suna Onengut-Gumuscu, Stephen S. Rich, Adam S. Butterworth, Anders Malarstig, John Danesh, John A. Todd

PLOS Genetics: published April 4, 2013 | https://doi.org/10.1371/journal.pgen.1003444

Cover

Steroid synthesis regulation: SUMO, Ftz-f1, Scavenger Receptors, and lipids meet in the ring gland

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