April 2012

As with DNA double-strand breaks, uncapped telomere ends lead to the formation of dicentric chromosomes. These chromosome configurations may initiate genomic instability by firing BFB-cycles after chromatin bridges break during mitosis. However, some of these may remain unbroken (blue, DNA) during furrow ingression (yellow, cortical actin) up to later stages of cytokinesis. A study by Pampalona et al. in human mammary epithelial cells exhibiting progressive telomere dysfunction reports that persistent chromatin bridges in the cleavage plane engender binucleated polyploid cells by failing to complete cytoplasmatic cell division.

Image Credit: Judit Pampalona (Universitat Autònoma de Barcelona).

Reviews

Modifier Genes and the Plasticity of Genetic Networks in Mice

Bruce A. Hamilton, Benjamin D. Yu

PLOS Genetics: published April 12, 2012 | https://doi.org/10.1371/journal.pgen.1002644

Defective Membrane Remodeling in Neuromuscular Diseases: Insights from Animal Models

Belinda S. Cowling, Anne Toussaint, Jean Muller, Jocelyn Laporte

PLOS Genetics: published April 5, 2012 | https://doi.org/10.1371/journal.pgen.1002595

Research Articles

Patterns of Ancestry, Signatures of Natural Selection, and Genetic Association with Stature in Western African Pygmies

Joseph P. Jarvis, Laura B. Scheinfeldt, Sameer Soi, Charla Lambert, Larsson Omberg, Bart Ferwerda, Alain Froment, Jean-Marie Bodo, William Beggs, Gabriel Hoffman, Jason Mezey, Sarah A. Tishkoff

PLOS Genetics: published April 26, 2012 | https://doi.org/10.1371/journal.pgen.1002641

Sequence-Specific Targeting of Dosage Compensation in Drosophila Favors an Active Chromatin Context

Artyom A. Alekseyenko, Joshua W. K. Ho, Shouyong Peng, Marnie Gelbart, Michael Y. Tolstorukov, Annette Plachetka, Peter V. Kharchenko, Youngsook L. Jung, Andrey A. Gorchakov, Erica Larschan, Tingting Gu, Aki Minoda, Nicole C. Riddle, Yuri B. Schwartz, Sarah C. R. Elgin, Gary H. Karpen, Vincenzo Pirrotta, Mitzi I. Kuroda, Peter J. Park

PLOS Genetics: published April 26, 2012 | https://doi.org/10.1371/journal.pgen.1002646

Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma

Janey L. Wiggs, Brian L. Yaspan, Michael A. Hauser, Jae H. Kang, R. Rand Allingham, Lana M. Olson, Wael Abdrabou, Bao J. Fan, Dan Y. Wang, Wendy Brodeur, Donald L. Budenz, Joseph Caprioli, Andrew Crenshaw, Kristy Crooks, Elizabeth DelBono, Kimberly F. Doheny, David S. Friedman, Douglas Gaasterland, Terry Gaasterland, Cathy Laurie, Richard K. Lee, Paul R. Lichter, Stephanie Loomis, Yutao Liu, Felipe A. Medeiros, Cathy McCarty, Daniel Mirel, Sayoko E. Moroi, David C. Musch, Anthony Realini, Frank W. Rozsa, Joel S. Schuman, Kathleen Scott, Kuldev Singh, Joshua D. Stein, Edward H. Trager, Paul VanVeldhuisen, Douglas Vollrath, Gadi Wollstein, Sachiko Yoneyama, Kang Zhang, Robert N. Weinreb, Jason Ernst, Manolis Kellis, Tomohiro Masuda, Don Zack, Julia E. Richards, Margaret Pericak-Vance, Louis R. Pasquale, Jonathan L. Haines

PLOS Genetics: published April 26, 2012 | https://doi.org/10.1371/journal.pgen.1002654

The Rac GTP Exchange Factor TIAM-1 Acts with CDC-42 and the Guidance Receptor UNC-40/DCC in Neuronal Protrusion and Axon Guidance

Rafael S. Demarco, Eric C. Struckhoff, Erik A. Lundquist

PLOS Genetics: published April 26, 2012 | https://doi.org/10.1371/journal.pgen.1002665

Budding Yeast Dma Proteins Control Septin Dynamics and the Spindle Position Checkpoint by Promoting the Recruitment of the Elm1 Kinase to the Bud Neck

Laura Merlini, Roberta Fraschini, Barbara Boettcher, Yves Barral, Giovanna Lucchini, Simonetta Piatti

PLOS Genetics: published April 26, 2012 | https://doi.org/10.1371/journal.pgen.1002670

The DSIF Subunits Spt4 and Spt5 Have Distinct Roles at Various Phases of Immunoglobulin Class Switch Recombination

Andre Stanlie, Nasim A. Begum, Hideo Akiyama, Tasuku Honjo

PLOS Genetics: published April 26, 2012 | https://doi.org/10.1371/journal.pgen.1002675

SPE-44 Implements Sperm Cell Fate

Madhura Kulkarni, Diane C. Shakes, Katie Guevel, Harold E. Smith

PLOS Genetics: published April 26, 2012 | https://doi.org/10.1371/journal.pgen.1002678

Progressive Telomere Dysfunction Causes Cytokinesis Failure and Leads to the Accumulation of Polyploid Cells

Judit Pampalona, Cristina Frías, Anna Genescà, Laura Tusell

PLOS Genetics: published April 26, 2012 | https://doi.org/10.1371/journal.pgen.1002679

Formation of Rigid, Non-Flight Forewings (Elytra) of a Beetle Requires Two Major Cuticular Proteins

Yasuyuki Arakane, Joseph Lomakin, Stevin H. Gehrke, Yasuaki Hiromasa, John M. Tomich, Subbaratnam Muthukrishnan, Richard W. Beeman, Karl J. Kramer, Michael R. Kanost

PLOS Genetics: published April 26, 2012 | https://doi.org/10.1371/journal.pgen.1002682

Genetic Inhibition of Solute-Linked Carrier 39 Family Transporter 1 Ameliorates Aβ Pathology in a Drosophila Model of Alzheimer's Disease

Minglin Lang, Lei Wang, Qiangwang Fan, Guiran Xiao, Xiaoxi Wang, Yi Zhong, Bing Zhou

PLOS Genetics: published April 26, 2012 | https://doi.org/10.1371/journal.pgen.1002683

Insulin Signaling Mediates Sexual Attractiveness in Drosophila

Tsung-Han Kuo, Tatyana Y. Fedina, Ingrid Hansen, Klaus Dreisewerd, Herman A. Dierick, Joanne Y. Yew, Scott D. Pletcher

PLOS Genetics: published April 26, 2012 | https://doi.org/10.1371/journal.pgen.1002684

Dynamics of Brassinosteroid Response Modulated by Negative Regulator LIC in Rice

Cui Zhang, Yunyuan Xu, Siyi Guo, Jiaying Zhu, Qing Huan, Huanhuan Liu, Lei Wang, Guanzheng Luo, Xiujie Wang, Kang Chong

PLOS Genetics: published April 26, 2012 | https://doi.org/10.1371/journal.pgen.1002686

PIWI Associated siRNAs and piRNAs Specifically Require the Caenorhabditis elegans HEN1 Ortholog henn-1

Taiowa A. Montgomery, Young-Soo Rim, Chi Zhang, Robert H. Dowen, Carolyn M. Phillips, Sylvia E. J. Fischer, Gary Ruvkun

PLOS Genetics: published April 19, 2012 | https://doi.org/10.1371/journal.pgen.1002616

The Caenorhabditis elegans HEN1 Ortholog, HENN-1, Methylates and Stabilizes Select Subclasses of Germline Small RNAs

Allison C. Billi, Amelia F. Alessi, Vishal Khivansara, Ting Han, Mallory Freeberg, Shohei Mitani, John K. Kim

PLOS Genetics: published April 19, 2012 | https://doi.org/10.1371/journal.pgen.1002617

Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population

Jordana T. Bell, Pei-Chien Tsai, Tsun-Po Yang, Ruth Pidsley, James Nisbet, Daniel Glass, Massimo Mangino, Guangju Zhai, Feng Zhang, Ana Valdes, So-Youn Shin, Emma L. Dempster, Robin M. Murray, Elin Grundberg, Asa K. Hedman, Alexandra Nica, Kerrin S. Small, The MuTHER Consortium, Emmanouil T. Dermitzakis, Mark I. McCarthy, Jonathan Mill, Tim D. Spector, Panos Deloukas

PLOS Genetics: published April 19, 2012 | https://doi.org/10.1371/journal.pgen.1002629

Polyglutamine Toxicity Is Controlled by Prion Composition and Gene Dosage in Yeast

He Gong, Nina V. Romanova, Kim D. Allen, Pavithra Chandramowlishwaran, Kavita Gokhale, Gary P. Newnam, Piotr Mieczkowski, Michael Y. Sherman, Yury O. Chernoff

PLOS Genetics: published April 19, 2012 | https://doi.org/10.1371/journal.pgen.1002634

Differing Requirements for RAD51 and DMC1 in Meiotic Pairing of Centromeres and Chromosome Arms in Arabidopsis thaliana

Olivier Da Ines, Kiyomi Abe, Chantal Goubely, Maria Eugenia Gallego, Charles I. White

PLOS Genetics: published April 19, 2012 | https://doi.org/10.1371/journal.pgen.1002636

Patterns of Cis Regulatory Variation in Diverse Human Populations

Barbara E. Stranger, Stephen B. Montgomery, Antigone S. Dimas, Leopold Parts, Oliver Stegle, Catherine E. Ingle, Magda Sekowska, George Davey Smith, David Evans, Maria Gutierrez-Arcelus, Alkes Price, Towfique Raj, James Nisbett, Alexandra C. Nica, Claude Beazley, Richard Durbin, Panos Deloukas, Emmanouil T. Dermitzakis

PLOS Genetics: published April 19, 2012 | https://doi.org/10.1371/journal.pgen.1002639

A New Role for Translation Initiation Factor 2 in Maintaining Genome Integrity

K. Elizabeth Madison, Mona R. Abdelmeguid, Erica N. Jones-Foster, Hiroshi Nakai

PLOS Genetics: published April 19, 2012 | https://doi.org/10.1371/journal.pgen.1002648

Competition between Replicative and Translesion Polymerases during Homologous Recombination Repair in Drosophila

Daniel P. Kane, Michael Shusterman, Yikang Rong, Mitch McVey

PLOS Genetics: published April 19, 2012 | https://doi.org/10.1371/journal.pgen.1002659

The Probability of a Gene Tree Topology within a Phylogenetic Network with Applications to Hybridization Detection

Yun Yu, James H. Degnan, Luay Nakhleh

PLOS Genetics: published April 19, 2012 | https://doi.org/10.1371/journal.pgen.1002660

A Coordinated Interdependent Protein Circuitry Stabilizes the Kinetochore Ensemble to Protect CENP-A in the Human Pathogenic Yeast Candida albicans

Jitendra Thakur, Kaustuv Sanyal

PLOS Genetics: published April 19, 2012 | https://doi.org/10.1371/journal.pgen.1002661

Genome-Wide Patterns of Arabidopsis Gene Expression in Nature

Christina L. Richards, Ulises Rosas, Joshua Banta, Naeha Bhambhra, Michael D. Purugganan

PLOS Genetics: published April 19, 2012 | https://doi.org/10.1371/journal.pgen.1002662

A Companion Cell–Dominant and Developmentally Regulated H3K4 Demethylase Controls Flowering Time in Arabidopsis via the Repression of FLC Expression

Hongchun Yang, Zhifu Han, Ying Cao, Di Fan, Hong Li, Huixian Mo, Yi Feng, Lei Liu, Zheng Wang, Yanling Yue, Sujuan Cui, She Chen, Jijie Chai, Ligeng Ma

PLOS Genetics: published April 19, 2012 | https://doi.org/10.1371/journal.pgen.1002664

dyschronic, a Drosophila Homolog of a Deaf-Blindness Gene, Regulates Circadian Output and Slowpoke Channels

James E. C. Jepson, Mohammad Shahidullah, Angelique Lamaze, Drew Peterson, Huihui Pan, Kyunghee Koh

PLOS Genetics: published April 19, 2012 | https://doi.org/10.1371/journal.pgen.1002671

Long-Range Chromosome Organization in E. coli: A Site-Specific System Isolates the Ter Macrodomain

Axel Thiel, Michèle Valens, Isabelle Vallet-Gely, Olivier Espéli, Frédéric Boccard

PLOS Genetics: published April 19, 2012 | https://doi.org/10.1371/journal.pgen.1002672

An Unbiased Assessment of the Role of Imprinted Genes in an Intergenerational Model of Developmental Programming

Elizabeth J. Radford, Elvira Isganaitis, Josep Jimenez-Chillaron, Joshua Schroeder, Michael Molla, Simon Andrews, Nathalie Didier, Marika Charalambous, Kirsten McEwen, Giovanna Marazzi, David Sassoon, Mary-Elizabeth Patti, Anne C. Ferguson-Smith

PLOS Genetics: published April 12, 2012 | https://doi.org/10.1371/journal.pgen.1002605

Type 2 Diabetes Risk Alleles Demonstrate Extreme Directional Differentiation among Human Populations, Compared to Other Diseases

Rong Chen, Erik Corona, Martin Sikora, Joel T. Dudley, Alex A. Morgan, Andres Moreno-Estrada, Geoffrey B. Nilsen, David Ruau, Stephen E. Lincoln, Carlos D. Bustamante, Atul J. Butte

PLOS Genetics: published April 12, 2012 | https://doi.org/10.1371/journal.pgen.1002621

Cell Contact–Dependent Outer Membrane Exchange in Myxobacteria: Genetic Determinants and Mechanism

Darshankumar T. Pathak, Xueming Wei, Alex Bucuvalas, Daniel H. Haft, Dietlind L. Gerloff, Daniel Wall

PLOS Genetics: published April 12, 2012 | https://doi.org/10.1371/journal.pgen.1002626

Dissection of Pol II Trigger Loop Function and Pol II Activity–Dependent Control of Start Site Selection In Vivo

Craig D. Kaplan, Huiyan Jin, Ivan Liang Zhang, Andrey Belyanin

PLOS Genetics: published April 12, 2012 | https://doi.org/10.1371/journal.pgen.1002627

Whole-Exome Sequencing and Homozygosity Analysis Implicate Depolarization-Regulated Neuronal Genes in Autism

Maria H. Chahrour, Timothy W. Yu, Elaine T. Lim, Bulent Ataman, Michael E. Coulter, R. Sean Hill, Christine R. Stevens, Christian R. Schubert, ARRA Autism Sequencing Collaboration, Michael E. Greenberg, Stacey B. Gabriel, Christopher A. Walsh

PLOS Genetics: published April 12, 2012 | https://doi.org/10.1371/journal.pgen.1002635

Hypoxia Disruption of Vertebrate CNS Pathfinding through EphrinB2 Is Rescued by Magnesium

Tamara J. Stevenson, Tony Trinh, Cory Kogelschatz, Esther Fujimoto, Mark E. Lush, Tatjana Piotrowski, Cameron J. Brimley, Joshua L. Bonkowsky

PLOS Genetics: published April 12, 2012 | https://doi.org/10.1371/journal.pgen.1002638

Population Structure of Hispanics in the United States: The Multi-Ethnic Study of Atherosclerosis

Ani Manichaikul, Walter Palmas, Carlos J. Rodriguez, Carmen A. Peralta, Jasmin Divers, Xiuqing Guo, Wei-Min Chen, Quenna Wong, Kayleen Williams, Kathleen F. Kerr, Kent D. Taylor, Michael Y. Tsai, Mark O. Goodarzi, Michèle M. Sale, Ana V. Diez-Roux, Stephen S. Rich, Jerome I. Rotter, Josyf C. Mychaleckyj

PLOS Genetics: published April 12, 2012 | https://doi.org/10.1371/journal.pgen.1002640

Mu Insertions Are Repaired by the Double-Strand Break Repair Pathway of Escherichia coli

Sooin Jang, Steven J. Sandler, Rasika M. Harshey

PLOS Genetics: published April 12, 2012 | https://doi.org/10.1371/journal.pgen.1002642

Coordinate Regulation of Lipid Metabolism by Novel Nuclear Receptor Partnerships

Pranali P. Pathare, Alex Lin, Karin E. Bornfeldt, Stefan Taubert, Marc R. Van Gilst

PLOS Genetics: published April 12, 2012 | https://doi.org/10.1371/journal.pgen.1002645

Transcriptional Regulation of Rod Photoreceptor Homeostasis Revealed by In Vivo NRL Targetome Analysis

Hong Hao, Douglas S. Kim, Bernward Klocke, Kory R. Johnson, Kairong Cui, Norimoto Gotoh, Chongzhi Zang, Janina Gregorski, Linn Gieser, Weiqun Peng, Yang Fann, Martin Seifert, Keji Zhao, Anand Swaroop

PLOS Genetics: published April 12, 2012 | https://doi.org/10.1371/journal.pgen.1002649

Context-Dependent Dual Role of SKI8 Homologs in mRNA Synthesis and Turnover

Eavan Dorcey, Antia Rodriguez-Villalon, Paula Salinas, Luca Santuari, Sylvain Pradervand, Keith Harshman, Christian S. Hardtke

PLOS Genetics: published April 12, 2012 | https://doi.org/10.1371/journal.pgen.1002652

Mutations in MITF and PAX3 Cause “Splashed White” and Other White Spotting Phenotypes in Horses

Regula Hauswirth, Bianca Haase, Marlis Blatter, Samantha A. Brooks, Dominik Burger, Cord Drögemüller, Vincent Gerber, Diana Henke, Jozef Janda, Rony Jude, K. Gary Magdesian, Jacqueline M. Matthews, Pierre-André Poncet, Vilhjálmur Svansson, Teruaki Tozaki, Lorna Wilkinson-White, M. Cecilia T. Penedo, Stefan Rieder, Tosso Leeb

PLOS Genetics: published April 12, 2012 | https://doi.org/10.1371/journal.pgen.1002653

Runs of Homozygosity Implicate Autozygosity as a Schizophrenia Risk Factor

Matthew C. Keller, Matthew A. Simonson, Stephan Ripke, Ben M. Neale, Pablo V. Gejman, Daniel P. Howrigan, Sang Hong Lee, Todd Lencz, Douglas F. Levinson, Patrick F. Sullivan, The Schizophrenia Psychiatric Genome-Wide Association Study Consortium

PLOS Genetics: published April 12, 2012 | https://doi.org/10.1371/journal.pgen.1002656

Deep Sequencing of Plant and Animal DNA Contained within Traditional Chinese Medicines Reveals Legality Issues and Health Safety Concerns

Megan L. Coghlan, James Haile, Jayne Houston, Dáithí C. Murray, Nicole E. White, Paula Moolhuijzen, Matthew I. Bellgard, Michael Bunce

PLOS Genetics: published April 12, 2012 | https://doi.org/10.1371/journal.pgen.1002657

Sex Reversal in C57BL/6J XY Mice Caused by Increased Expression of Ovarian Genes and Insufficient Activation of the Testis Determining Pathway

Stephanie M. Correa, Linda L. Washburn, Ravi S. Kahlon, Michelle C. Musson, Gerrit J. Bouma, Eva M. Eicher, Kenneth H. Albrecht

PLOS Genetics: published April 5, 2012 | https://doi.org/10.1371/journal.pgen.1002569

Fine-Scale Mapping of Natural Variation in Fly Fecundity Identifies Neuronal Domain of Expression and Function of an Aquaporin

Alan O. Bergland, Hyo-seok Chae, Young-Joon Kim, Marc Tatar

PLOS Genetics: published April 5, 2012 | https://doi.org/10.1371/journal.pgen.1002631

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Unresolved chromatin bridges during cytokinesis.

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