Pictured is a confocal image of live cells from a larval gland expressing a DsRED-tagged protein loaded into secretory granules and a GFP-tagged reporter protein localized to the nucleus. For the RED cargo to be synthesized and secreted, the tissue must be exposed to two different pulses of hormone. These steroid signals are also mediated by two distinct functional receptors, only one of which was previously characterized (see Costantino et al., doi:10.1371/journal.pgen.1000102).
Image Credit: Image generated by Benjamin F. B. Costantino and Daniel K. Bricker.
Interview
The Exception That Proves the Rule: An Interview with Jenny Graves
PLOS Genetics: published June 27, 2008 | https://doi.org/10.1371/journal.pgen.1000063
Research Articles
CRA-1 Uncovers a Double-Strand Break-Dependent Pathway Promoting the Assembly of Central Region Proteins on Chromosome Axes During C. elegans Meiosis
PLOS Genetics: published June 6, 2008 | https://doi.org/10.1371/journal.pgen.1000088
Genetic Identification of a Network of Factors that Functionally Interact with the Nucleosome Remodeling ATPase ISWI
PLOS Genetics: published June 6, 2008 | https://doi.org/10.1371/journal.pgen.1000089
Combined Analysis of Murine and Human Microarrays and ChIP Analysis Reveals Genes Associated with the Ability of MYC To Maintain Tumorigenesis
PLOS Genetics: published June 6, 2008 | https://doi.org/10.1371/journal.pgen.1000090
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Genome-Wide Analysis Reveals a Complex Pattern of Genomic Imprinting in Mice
PLOS Genetics: published June 6, 2008 | https://doi.org/10.1371/journal.pgen.1000091
Novel Roles for MLH3 Deficiency and TLE6-Like Amplification in DNA Mismatch Repair-Deficient Gastrointestinal Tumorigenesis and Progression
PLOS Genetics: published June 13, 2008 | https://doi.org/10.1371/journal.pgen.1000092
Regulation and Role of Arabidopsis CUL4-DDB1A-DDB2 in Maintaining Genome Integrity upon UV Stress
PLOS Genetics: published June 13, 2008 | https://doi.org/10.1371/journal.pgen.1000093
Overlapping Protein-Encoding Genes in Pseudomonas fluorescens Pf0-1
PLOS Genetics: published June 13, 2008 | https://doi.org/10.1371/journal.pgen.1000094
Trends in Selenium Utilization in Marine Microbial World Revealed through the Analysis of the Global Ocean Sampling (GOS) Project
PLOS Genetics: published June 13, 2008 | https://doi.org/10.1371/journal.pgen.1000095
SINE RNA Induces Severe Developmental Defects in Arabidopsis thaliana and Interacts with HYL1 (DRB1), a Key Member of the DCL1 Complex
PLOS Genetics: published June 13, 2008 | https://doi.org/10.1371/journal.pgen.1000096
Mitochondrial Morphogenesis, Dendrite Development, and Synapse Formation in Cerebellum Require both Bcl-w and the Glutamate Receptor δ2
PLOS Genetics: published June 13, 2008 | https://doi.org/10.1371/journal.pgen.1000097
Evaluating Statistical Methods Using Plasmode Data Sets in the Age of Massive Public Databases: An Illustration Using False Discovery Rates
PLOS Genetics: published June 20, 2008 | https://doi.org/10.1371/journal.pgen.1000098
A Drastic Reduction in the Life Span of Cystatin C L68Q Carriers Due to Life-Style Changes during the Last Two Centuries
PLOS Genetics: published June 20, 2008 | https://doi.org/10.1371/journal.pgen.1000099
An Evolutionarily Conserved Sexual Signature in the Primate Brain
PLOS Genetics: published June 20, 2008 | https://doi.org/10.1371/journal.pgen.1000100
Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis
PLOS Genetics: published June 20, 2008 | https://doi.org/10.1371/journal.pgen.1000101
A Novel Ecdysone Receptor Mediates Steroid-Regulated Developmental Events during the Mid-Third Instar of Drosophila
PLOS Genetics: published June 20, 2008 | https://doi.org/10.1371/journal.pgen.1000102
Incompatibilities Involving Yeast Mismatch Repair Genes: A Role for Genetic Modifiers and Implications for Disease Penetrance and Variation in Genomic Mutation Rates
PLOS Genetics: published June 20, 2008 | https://doi.org/10.1371/journal.pgen.1000103
Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53
PLOS Genetics: published June 27, 2008 | https://doi.org/10.1371/journal.pgen.1000104
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Low Levels of DNA Polymerase Alpha Induce Mitotic and Meiotic Instability in the Ribosomal DNA Gene Cluster of Saccharomyces cerevisiae
PLOS Genetics: published June 27, 2008 | https://doi.org/10.1371/journal.pgen.1000105
Sepsid even-skipped Enhancers Are Functionally Conserved in Drosophila Despite Lack of Sequence Conservation
PLOS Genetics: published June 27, 2008 | https://doi.org/10.1371/journal.pgen.1000106
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A Large-Scale Rheumatoid Arthritis Genetic Study Identifies Association at Chromosome 9q33.2
PLOS Genetics: published June 27, 2008 | https://doi.org/10.1371/journal.pgen.1000107
Metabolic Actions of Estrogen Receptor Beta (ERβ) are Mediated by a Negative Cross-Talk with PPARγ
PLOS Genetics: published June 27, 2008 | https://doi.org/10.1371/journal.pgen.1000108
Calibrating the Performance of SNP Arrays for Whole-Genome Association Studies
PLOS Genetics: published June 27, 2008 | https://doi.org/10.1371/journal.pgen.1000109
Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair
PLOS Genetics: published June 27, 2008 | https://doi.org/10.1371/journal.pgen.1000110
Global Mapping of DNA Methylation in Mouse Promoters Reveals Epigenetic Reprogramming of Pluripotency Genes
PLOS Genetics: published June 27, 2008 | https://doi.org/10.1371/journal.pgen.1000116
Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women
PLOS Genetics: published July 4, 2008 | https://doi.org/10.1371/journal.pgen.1000118
E1 Ubiquitin-Activating Enzyme UBA-1 Plays Multiple Roles throughout C. elegans Development
PLOS Genetics: published July 18, 2008 | https://doi.org/10.1371/journal.pgen.1000131