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Open Access
Peer-reviewed
Research Article
A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma
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Dirk Smith ,
Contributed equally to this work with: Dirk Smith, Hannes Helgason
Current Address: Insight BioConsulting, LLC, Bainbridge Island, Washington, United States of America,
Affiliation Amgen Inc., Discovery Research, South San Francisco, California, United States of America
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Hannes Helgason ,
Contributed equally to this work with: Dirk Smith, Hannes Helgason
Affiliations deCODE genetics / Amgen Inc., Reykjavík, Iceland, School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland
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Patrick Sulem,
Affiliation deCODE genetics / Amgen Inc., Reykjavík, Iceland
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Unnur Steina Bjornsdottir,
Affiliation Department of Medicine, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland
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Ai Ching Lim,
Affiliation Amgen Inc., Discovery Research, South San Francisco, California, United States of America
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Gardar Sveinbjornsson,
Affiliation deCODE genetics / Amgen Inc., Reykjavík, Iceland
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Haruki Hasegawa,
Affiliation Amgen Inc., Discovery Research, South San Francisco, California, United States of America
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Michael Brown,
Current Address: Adimab, Lebanon, New Hampshire, United States of America
Affiliation Amgen Inc., Discovery Research, South San Francisco, California, United States of America
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Randal R. Ketchem,
Current Address: Just Biotherapeutics, Seattle, Washington, United States of America
Affiliation Amgen Inc., Discovery Research, South San Francisco, California, United States of America
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Monica Gavala,
Affiliation Amgen Inc., Discovery Research, South San Francisco, California, United States of America
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Logan Garrett,
Current Address: Absci, Portland, Oregon, United States of America
Affiliation Amgen Inc., Discovery Research, South San Francisco, California, United States of America
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Adalbjorg Jonasdottir,
Affiliation deCODE genetics / Amgen Inc., Reykjavík, Iceland
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Aslaug Jonasdottir,
Affiliation deCODE genetics / Amgen Inc., Reykjavík, Iceland
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Asgeir Sigurdsson,
Affiliation deCODE genetics / Amgen Inc., Reykjavík, Iceland
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Olafur T. Magnusson,
Affiliation deCODE genetics / Amgen Inc., Reykjavík, Iceland
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Gudmundur I. Eyjolfsson,
Affiliation The Laboratory in Mjodd, RAM, Reykjavik, Iceland
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Isleifur Olafsson,
Affiliation Department of Clinical Biochemistry, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland
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Pall Torfi Onundarson,
Affiliations Laboratory Hematology, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland, Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
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Olof Sigurdardottir,
Affiliations Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland, Department of Clinical Biochemistry, Akureyri Hospital, Akureyri, Iceland
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David Gislason,
Affiliation Department of Respiratory Medicine and Sleep, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland
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Thorarinn Gislason,
Affiliations Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland, Department of Respiratory Medicine and Sleep, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland
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Bjorn Runar Ludviksson,
Affiliations Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland, Department of Immunology, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland
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Dora Ludviksdottir,
Affiliations Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland, Department of Respiratory Medicine and Sleep, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland
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H. Marike Boezen,
Affiliations GRIAC research institute, Groningen, The Netherlands, University Medical Center Groningen, University of Groningen, Department of Epidemiology, Groningen, The Netherlands
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Andrea Heinzmann,
Affiliation Center for Pediatrics, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center – University of Freiburg, Faculty of Medicine, Freiburg, Germany
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Marcus Krueger,
Affiliation Center for Pediatrics, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center – University of Freiburg, Faculty of Medicine, Freiburg, Germany
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Celeste Porsbjerg,
Affiliation Department of Respiratory Medicine, Bispebjerg University Hospital, Copenhagen University, Copenhagen, Denmark
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Tarunveer S. Ahluwalia,
Affiliation COPSAC (Copenhagen Prospective Studies on Asthma in Childhood), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
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Johannes Waage,
Affiliation COPSAC (Copenhagen Prospective Studies on Asthma in Childhood), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
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Vibeke Backer,
Affiliation Department of Respiratory Medicine, Bispebjerg University Hospital, Copenhagen University, Copenhagen, Denmark
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Klaus A. Deichmann,
Affiliation Center for Pediatrics, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center – University of Freiburg, Faculty of Medicine, Freiburg, Germany
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Gerard H. Koppelman,
Affiliations GRIAC research institute, Groningen, The Netherlands, University Medical Center Groningen, University of Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, Groningen, The Netherlands
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Klaus Bønnelykke,
Affiliation COPSAC (Copenhagen Prospective Studies on Asthma in Childhood), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
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Hans Bisgaard,
Affiliation COPSAC (Copenhagen Prospective Studies on Asthma in Childhood), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
⨯ - Gisli Masson,
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Unnur Thorsteinsdottir,
Affiliations deCODE genetics / Amgen Inc., Reykjavík, Iceland, Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
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Daniel F. Gudbjartsson,
Affiliations deCODE genetics / Amgen Inc., Reykjavík, Iceland, School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland
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James A. Johnston,
Affiliation Amgen Inc., Discovery Research, South San Francisco, California, United States of America
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Ingileif Jonsdottir ,
* E-mail: kstefans@decode.is (KS); ingileif.jonsdottir@decode.is (IJ)
Affiliations deCODE genetics / Amgen Inc., Reykjavík, Iceland, Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland, Department of Immunology, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland
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Kari Stefansson
* E-mail: kstefans@decode.is (KS); ingileif.jonsdottir@decode.is (IJ)
Affiliations deCODE genetics / Amgen Inc., Reykjavík, Iceland, Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
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A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma
- Dirk Smith,
- Hannes Helgason,
- Patrick Sulem,
- Unnur Steina Bjornsdottir,
- Ai Ching Lim,
- Gardar Sveinbjornsson,
- Haruki Hasegawa,
- Michael Brown,
- Randal R. Ketchem,
- Monica Gavala
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- Published: March 8, 2017
- https://doi.org/10.1371/journal.pgen.1006659