A robust and adaptive framework for interaction testing in quantitative traits between multiple genetic loci and exposure variables

• Julian Hecker ,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft

  * E-mail: rejhe@channing.harvard.edu

  Affiliations Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-7918-089X

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• Dmitry Prokopenko,

  Roles Conceptualization, Data curation, Writing – original draft

  Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Genetics and Aging Unit and McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-1844-5652

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• Matthew Moll,

  Roles Data curation, Writing – review & editing

  Affiliations Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-0683-0975

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• Sanghun Lee,

  Roles Writing – review & editing

  Affiliations Department of Medical Consilience, Division of Medicine, Graduate School, Dankook University, Yongin, South Korea, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-0573-9555

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• Wonji Kim,

  Roles Data curation, Writing – review & editing

  Affiliations Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-1249-797X

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• Dandi Qiao,

  Roles Data curation, Writing – review & editing

  Affiliations Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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• Kirsten Voorhies,

  Roles Writing – review & editing

  Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Department of Population Medicine, PRecisiOn Medicine Translational Research (PROMoTeR) Center, Harvard Pilgrim Health Care, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-0249-4337

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• Woori Kim,

  Roles Data curation, Writing – review & editing

  Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Systems Biology and Computer Science Program, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0001-7573-7718

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• Stijn Vansteelandt,

  Roles Methodology, Writing – review & editing

  Affiliations Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Gent, Belgium, Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom

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• Brian D. Hobbs,

  Roles Data curation, Writing – review & editing

  Affiliations Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-9564-0745

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• Michael H. Cho,

  Roles Data curation, Resources, Writing – review & editing

  Affiliations Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-4907-1657

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• Edwin K. Silverman,

  Roles Writing – review & editing

  Affiliations Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-3641-3822

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• Sharon M. Lutz,

  Roles Methodology, Writing – review & editing

  Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America, Department of Population Medicine, PRecisiOn Medicine Translational Research (PROMoTeR) Center, Harvard Pilgrim Health Care, Boston, Massachusetts, United States of America

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• Dawn L. DeMeo,

  Roles Writing – review & editing

  Affiliations Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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• Scott T. Weiss,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft

  Affiliations Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-7196-303X

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•  [ ... ],
• Christoph Lange

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – original draft

  Affiliations Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

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