A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing

• Tao Chen ,

  Contributed equally to this work with: Tao Chen, Bin Zhang, Thomas Ziegenhals, Archana B. Prusty

  Roles Data curation, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliation Laboratory for Functional Genomics and Systems Biology, Berlin Institute for Medical System Biology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

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• Bin Zhang ,

  Contributed equally to this work with: Tao Chen, Bin Zhang, Thomas Ziegenhals, Archana B. Prusty

  Roles Data curation, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliations Department of Biology, Southern University of Science and Technology (SUSTech), Shenzhen, China, Cancer Science Institute of Singapore, National University of Singapore, Singapore

  http://orcid.org/0000-0001-8835-8370

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• Thomas Ziegenhals ,

  Contributed equally to this work with: Tao Chen, Bin Zhang, Thomas Ziegenhals, Archana B. Prusty

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany

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• Archana B. Prusty ,

  Contributed equally to this work with: Tao Chen, Bin Zhang, Thomas Ziegenhals, Archana B. Prusty

  Roles Investigation, Writing – review & editing

  Affiliation Department of Biochemistry, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany

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• Sebastian Fröhler,

  Roles Formal analysis

  Affiliation Laboratory for Functional Genomics and Systems Biology, Berlin Institute for Medical System Biology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

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• Clemens Grimm,

  Roles Investigation

  Affiliation Department of Biochemistry, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany

  http://orcid.org/0000-0001-9085-5130

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• Yuhui Hu,

  Roles Investigation

  Affiliation Department of Biology, Southern University of Science and Technology (SUSTech), Shenzhen, China

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• Bernhard Schaefke,

  Roles Investigation

  Affiliations Department of Biology, Southern University of Science and Technology (SUSTech), Shenzhen, China, Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology (SUSTech), Shenzhen, China

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• Liang Fang,

  Roles Investigation

  Affiliations Department of Biology, Southern University of Science and Technology (SUSTech), Shenzhen, China, Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology (SUSTech), Shenzhen, China

  http://orcid.org/0000-0003-4502-1756

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• Min Zhang,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Biology, Southern University of Science and Technology (SUSTech), Shenzhen, China

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• Nadine Kraemer,

  Roles Investigation

  Affiliations Charité-Universitätsmedizin Berlin, Institute of Cell Biology and Neurobiology, Berlin, Germany, Charité-Universitätsmedizin Berlin, Department of Pediatric Neurology, Berlin, Germany

  http://orcid.org/0000-0002-7002-5161

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• Angela M. Kaindl ,

  Roles Conceptualization, Investigation, Resources

  * E-mail: utz.fischer@biozentrum.uni-wuerzburg.de (UF); angela.kaindl@charite.de (AK); chenw@sustech.edu.cn (WC)

  Affiliations Charité-Universitätsmedizin Berlin, Institute of Cell Biology and Neurobiology, Berlin, Germany, Charité-Universitätsmedizin Berlin, Department of Pediatric Neurology, Berlin, Germany, Charité-Universitätsmedizin Berlin, Center for Chronically Sick Children, Berlin, Germany

  http://orcid.org/0000-0001-9454-206X

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• Utz Fischer ,

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: utz.fischer@biozentrum.uni-wuerzburg.de (UF); angela.kaindl@charite.de (AK); chenw@sustech.edu.cn (WC)

  Affiliation Department of Biochemistry, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany

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• Wei Chen

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: utz.fischer@biozentrum.uni-wuerzburg.de (UF); angela.kaindl@charite.de (AK); chenw@sustech.edu.cn (WC)

  Affiliations Department of Biology, Southern University of Science and Technology (SUSTech), Shenzhen, China, Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology (SUSTech), Shenzhen, China

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