Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid

Fiona Semple; Heather MacPherson; Sheila Webb; Fiona Kilanowski; Laura Lettice; Sarah L. McGlasson; Ann P. Wheeler; Valerie Chen; Glenn L. Millhauser; Lauren Melrose; Donald J. Davidson; Julia R. Dorin

doi:10.1371/journal.pgen.1005673

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Open Access

Peer-reviewed

Research Article

Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid

Fiona Semple,

Affiliations MRC Centre for Inflammation Research, University of Edinburgh, Queen’s Medical Research Institute (QMRI), Edinburgh, United Kingdom, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom
⨯
Heather MacPherson,

Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom
⨯
Sheila Webb,

Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom
⨯
Fiona Kilanowski,

Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom
⨯
Laura Lettice,

Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom
⨯
Sarah L. McGlasson,

Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom
⨯
Ann P. Wheeler,

Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom
⨯
Valerie Chen,

Affiliation Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, California, United States of America
⨯
Glenn L. Millhauser,

Affiliation Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, California, United States of America
⨯
Lauren Melrose,

Affiliation MRC Centre for Inflammation Research, University of Edinburgh, Queen’s Medical Research Institute (QMRI), Edinburgh, United Kingdom
⨯
Donald J. Davidson,

Affiliation MRC Centre for Inflammation Research, University of Edinburgh, Queen’s Medical Research Institute (QMRI), Edinburgh, United Kingdom
⨯
Julia R. Dorin

* E-mail: Julia.dorin@ed.ac.uk

Affiliations MRC Centre for Inflammation Research, University of Edinburgh, Queen’s Medical Research Institute (QMRI), Edinburgh, United Kingdom, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom
⨯

Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid

Fiona Semple,
Heather MacPherson,
Sheila Webb,
Fiona Kilanowski,
Laura Lettice,
Sarah L. McGlasson,
Ann P. Wheeler,
Valerie Chen,
Glenn L. Millhauser,
Lauren Melrose

Published: December 8, 2015
https://doi.org/10.1371/journal.pgen.1005673

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