Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality

• Nicholas C. Wu,

  Affiliations Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America,, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, United States of America,

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• C. Anders Olson,

  Affiliation Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America,

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• Yushen Du,

  Affiliation Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America,

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• Shuai Le,

  Affiliation Department of Microbiology, Third Military Medical University, Chongqing, 400038, China

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• Kevin Tran,

  Affiliation Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America,

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• Roland Remenyi,

  Affiliation Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America,

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• Danyang Gong,

  Affiliation Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America,

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• Laith Q. Al-Mawsawi,

  Affiliation Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America,

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• Hangfei Qi,

  Affiliation Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America,

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• Ting-Ting Wu,

  Affiliation Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America,

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• Ren Sun

  * E-mail: RSun@mednet.ucla.edu

  Affiliations Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America,, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, United States of America,, AIDS Institute, University of California, Los Angeles, Los Angeles, California, United States of America

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