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Correction: Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality

  • Nicholas C. Wu,
  • C. Anders Olson,
  • Yushen Du,
  • Shuai Le,
  • Kevin Tran,
  • Roland Remenyi,
  • Danyang Gong,
  • Laith Q. Al-Mawsawi,
  • Hangfei Qi,
  • Ting-Ting Wu,
  • Ren Sun

Correction: Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality

  • Nicholas C. Wu, 
  • C. Anders Olson, 
  • Yushen Du, 
  • Shuai Le, 
  • Kevin Tran, 
  • Roland Remenyi, 
  • Danyang Gong, 
  • Laith Q. Al-Mawsawi, 
  • Hangfei Qi, 
  • Ting-Ting Wu
PLOS
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There is a labelling error in Panel C of Fig 2. The labels ‘PA N-terminal Domain’ and ‘PA C-terminal Domain’ are swapped. The left label should be ‘PA N-terminal Domain’, and the right label should be ‘PA C-terminal Domain’. The authors have provided the correct version of Fig 2 which can be viewed below.

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Fig 2. Fitness profiling of PA influenza virus polymerase subunit.

(A) Correlations of log10 relative frequency of individual point mutations between replicates are shown. Relative frequencymutation i = (Occurrence frequencymutation i)/(Occurrence frequencyWT) (B) Log10 RF indices for silent mutations, nonsense mutations, and missense mutations are shown as histograms. Point mutations located at the 5 terminal 400 bp and 3 terminal 400 bp regions are not included in this analysis to avoid complication by the vRNA packaging signal [93, 94]. (C) The locations of the PA C-terminal domain and the PA N-terminal domain are shown as white boxes. The locations of the mutated regions in each mutant library are shown as green boxes. Log10 RF indices for individual point mutations are plotted across the PA gene. Each point mutation is colored coded as in panel B. Purple: silent mutations; Cyan: nonsense mutations; Brown: missense mutations. A smooth curve was fitted by loess and plotted for each point mutation type.

https://doi.org/10.1371/journal.pgen.1006709.g001

Reference

  1. 1. Wu NC, Olson CA, Du Y, Le S, Tran K, Remenyi R, et al. (2015) Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality. PLoS Genet 11(7): e1005310. pmid:26132554