There is a labelling error in Panel C of Fig 2. The labels ‘PA N-terminal Domain’ and ‘PA C-terminal Domain’ are swapped. The left label should be ‘PA N-terminal Domain’, and the right label should be ‘PA C-terminal Domain’. The authors have provided the correct version of Fig 2 which can be viewed below.
(A) Correlations of log10 relative frequency of individual point mutations between replicates are shown. Relative frequencymutation i = (Occurrence frequencymutation i)/(Occurrence frequencyWT) (B) Log10 RF indices for silent mutations, nonsense mutations, and missense mutations are shown as histograms. Point mutations located at the 5 terminal 400 bp and 3 terminal 400 bp regions are not included in this analysis to avoid complication by the vRNA packaging signal [93, 94]. (C) The locations of the PA C-terminal domain and the PA N-terminal domain are shown as white boxes. The locations of the mutated regions in each mutant library are shown as green boxes. Log10 RF indices for individual point mutations are plotted across the PA gene. Each point mutation is colored coded as in panel B. Purple: silent mutations; Cyan: nonsense mutations; Brown: missense mutations. A smooth curve was fitted by loess and plotted for each point mutation type.
Citation: Wu NC, Olson CA, Du Y, Le S, Tran K, Remenyi R, et al. (2017) Correction: Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality. PLoS Genet 13(4): e1006709. https://doi.org/10.1371/journal.pgen.1006709
Published: April 25, 2017
Copyright: © 2017 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.