Selective and Genetic Constraints on Pneumococcal Serotype Switching

Nicholas J. Croucher; Lisa Kagedan; Claudette M. Thompson; Julian Parkhill; Stephen D. Bentley; Jonathan A. Finkelstein; Marc Lipsitch; William P. Hanage

doi:10.1371/journal.pgen.1005095

Loading metrics

Open Access

Peer-reviewed

Research Article

Selective and Genetic Constraints on Pneumococcal Serotype Switching

Nicholas J. Croucher ,

* E-mail: n.croucher@imperial.ac.uk

Affiliations Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom, Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America
⨯
Lisa Kagedan,

Affiliation Department of Epidemiology and Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America
⨯
Claudette M. Thompson,

Affiliation Department of Epidemiology and Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America
⨯
Julian Parkhill,

Affiliation Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Stephen D. Bentley,

Affiliation Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Jonathan A. Finkelstein,

Affiliations Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, United States of America, Division of General Pediatrics, Boston Children’s Hospital, Boston, Massachusetts, United States of America
⨯
Marc Lipsitch,

Affiliations Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America, Department of Epidemiology and Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America
⨯
William P. Hanage

Affiliation Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America
⨯

Selective and Genetic Constraints on Pneumococcal Serotype Switching

Nicholas J. Croucher,
Lisa Kagedan,
Claudette M. Thompson,
Julian Parkhill,
Stephen D. Bentley,
Jonathan A. Finkelstein,
Marc Lipsitch,
William P. Hanage

Published: March 31, 2015
https://doi.org/10.1371/journal.pgen.1005095

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Genetic loci
Is the Subject Area "Genetic loci" applicable to this article?

Thanks for your feedback.
Sequence clustering
Is the Subject Area "Sequence clustering" applicable to this article?

Thanks for your feedback.
Genomics
Is the Subject Area "Genomics" applicable to this article?

Thanks for your feedback.
DNA recombination
Is the Subject Area "DNA recombination" applicable to this article?

Thanks for your feedback.
Phylogenetics
Is the Subject Area "Phylogenetics" applicable to this article?

Thanks for your feedback.
Transformation associated recombination
Is the Subject Area "Transformation associated recombination" applicable to this article?

Thanks for your feedback.
Homologous recombination
Is the Subject Area "Homologous recombination" applicable to this article?

Thanks for your feedback.
Permutation
Is the Subject Area "Permutation" applicable to this article?

Thanks for your feedback.