Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

• Anubha Mahajan,

  Affiliation Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Xueling Sim,

  Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Hui Jin Ng,

  Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Alisa Manning,

  Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• Manuel A. Rivas,

  Affiliation Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Heather M. Highland,

  Affiliation Human Genetics Center, The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Adam E. Locke,

  Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Niels Grarup,

  Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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• Hae Kyung Im,

  Affiliation Department of Health Studies, Biostatistics Laboratory, The University of Chicago, Chicago, Illinois, United States of America

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• Pablo Cingolani,

  Affiliations School of Computer Science, McGill University, Montreal, Quebec, Canada, McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada

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• Jason Flannick,

  Affiliations Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Pierre Fontanillas,

  Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• Christian Fuchsberger,

  Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Kyle J. Gaulton,

  Affiliation Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Tanya M. Teslovich,

  Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• N. William Rayner,

  Affiliations Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

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• Neil R. Robertson,

  Affiliations Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Nicola L. Beer,

  Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Jana K. Rundle,

  Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Jette Bork-Jensen,

  Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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• Claes Ladenvall,

  Affiliation Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden

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• Christine Blancher,

  Affiliation High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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• David Buck,

  Affiliation High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Gemma Buck,

  Affiliation High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Noël P. Burtt,

  Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• Stacey Gabriel,

  Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• Anette P. Gjesing,

  Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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• Christopher J. Groves,

  Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Mette Hollensted,

  Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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• Jeroen R. Huyghe,

  Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Anne U. Jackson,

  Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Goo Jun,

  Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Johanne Marie Justesen,

  Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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• Massimo Mangino,

  Affiliation Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom

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• Jacquelyn Murphy,

  Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• Matt Neville,

  Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Robert Onofrio,

  Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• Kerrin S. Small,

  Affiliation Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom

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• Heather M. Stringham,

  Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Ann-Christine Syvänen,

  Affiliation Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

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• Joseph Trakalo,

  Affiliation High Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Goncalo Abecasis,

  Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Graeme I. Bell,

  Affiliation Departments of Medicine and Human Genetics, The University of Chicago, Chicago, Illinois, United States of America

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• John Blangero,

  Affiliation Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America

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• Nancy J. Cox,

  Affiliation Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, United States of America

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• Ravindranath Duggirala,

  Affiliation Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America

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• Craig L. Hanis,

  Affiliation Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Mark Seielstad,

  Affiliations Blood Systems Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine & Institute for Human Genetics, University of California, San Francisco, San Francisco, California, United States of America

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• James G. Wilson,

  Affiliation Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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• Cramer Christensen,

  Affiliation Department of Internal Medicine and Endocrinology, Vejle Hospital, Vejle, Denmark

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• Ivan Brandslund,

  Affiliations Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark, Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark

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• Rainer Rauramaa,

  Affiliation Foundation for Research in Health, Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland

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• Gabriela L. Surdulescu,

  Affiliation Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom

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• Alex S. F. Doney,

  Affiliation Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, United Kingdom

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• Lars Lannfelt,

  Affiliation Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden

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• Allan Linneberg,

  Affiliations Department of Clinical Experimental Research, Glostrup University Hospital, Glostrup, Denmark, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark

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• Bo Isomaa,

  Affiliations Department of Social Services and Health Care, Jakobstad, Finland, Folkhälsan Research Centre, Helsinki, Finland

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• Tiinamaija Tuomi,

  Affiliations Folkhälsan Research Centre, Helsinki, Finland, Department of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland

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• Marit E. Jørgensen,

  Affiliation Steno Diabetes Center, Gentofte, Denmark

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• Torben Jørgensen,

  Affiliations Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark, Faculty of Medicine, University of Aalborg, Aalborg, Denmark

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• Johanna Kuusisto,

  Affiliations Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland, Kuopio University Hospital, Kuopio, Finland

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• Matti Uusitupa,

  Affiliation Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland

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• Veikko Salomaa,

  Affiliation National Institute for Health and Welfare, Helsinki, Finland

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• Timothy D. Spector,

  Affiliation Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom

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• Andrew D. Morris,

  Affiliation Clinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee, United Kingdom

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• Colin N. A. Palmer,

  Affiliation Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, United Kingdom

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• Francis S. Collins,

  Affiliation Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Karen L. Mohlke,

  Affiliation Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Richard N. Bergman,

  Affiliation Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, California, United States of America

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• Erik Ingelsson,

  Affiliations Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

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• Lars Lind,

  Affiliation Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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• Jaakko Tuomilehto,

  Affiliations Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia, Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), University Hospital LaPaz, Autonomous University of Madrid, Madrid, Spain, Center for Vascular Prevention, Danube University Krems, Krems, Austria, Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland

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• Torben Hansen,

  Affiliations The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

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• Richard M. Watanabe,

  Affiliations Department of Physiology & Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, Diabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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• Inga Prokopenko,

  Affiliations Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, United Kingdom

  ⨯
• Josee Dupuis,

  Affiliations National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

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• Fredrik Karpe,

  Affiliations Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, United Kingdom

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• Leif Groop,

  Affiliation Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden

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• Markku Laakso,

  Affiliations Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland, Kuopio University Hospital, Kuopio, Finland

  ⨯
• Oluf Pedersen,

  Affiliation The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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• Jose C. Florez,

  Affiliations Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  ⨯
• Andrew P. Morris,

  Affiliations Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom, Estonian Genome Centre, University of Tartu, Tartu, Estonia

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• David Altshuler,

  Affiliations Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• James B. Meigs,

  Affiliation General Medicine Division, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Michael Boehnke,

  Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Mark I. McCarthy,

  Affiliations Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, United Kingdom

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• Cecilia M. Lindgren ,

  * E-mail: celi@well.ox.ac.uk (CML); anna.gloyn@drl.ox.ac.uk (ALG)

  Affiliations Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• Anna L. Gloyn ,

  * E-mail: celi@well.ox.ac.uk (CML); anna.gloyn@drl.ox.ac.uk (ALG)

  Affiliations Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, United Kingdom

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•  [ ... ],
• On Behalf of the T2D-GENES consortium and GoT2D consortium

  ¶Members of both consortia are listed in the Acknowledgments.

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