Vangl2-Regulated Polarisation of Second Heart Field-Derived Cells Is Required for Outflow Tract Lengthening during Cardiac Development

Simon A. Ramsbottom; Vipul Sharma; Hong Jun Rhee; Lorraine Eley; Helen M. Phillips; Hannah F. Rigby; Charlotte Dean; Bill Chaudhry; Deborah J. Henderson

doi:10.1371/journal.pgen.1004871

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Open Access

Peer-reviewed

Research Article

Vangl2-Regulated Polarisation of Second Heart Field-Derived Cells Is Required for Outflow Tract Lengthening during Cardiac Development

Simon A. Ramsbottom ,

Contributed equally to this work with: Simon A. Ramsbottom, Vipul Sharma

Affiliation Institute of Genetic Medicine, Newcastle University, Centre for Life, Newcastle upon Tyne, United Kingdom
⨯
Vipul Sharma ,

Contributed equally to this work with: Simon A. Ramsbottom, Vipul Sharma

Affiliation Institute of Genetic Medicine, Newcastle University, Centre for Life, Newcastle upon Tyne, United Kingdom
⨯
Hong Jun Rhee,

Affiliation Institute of Genetic Medicine, Newcastle University, Centre for Life, Newcastle upon Tyne, United Kingdom
⨯
Lorraine Eley,

Affiliation Institute of Genetic Medicine, Newcastle University, Centre for Life, Newcastle upon Tyne, United Kingdom
⨯
Helen M. Phillips,

Affiliation Institute of Genetic Medicine, Newcastle University, Centre for Life, Newcastle upon Tyne, United Kingdom
⨯
Hannah F. Rigby,

Affiliation Institute of Genetic Medicine, Newcastle University, Centre for Life, Newcastle upon Tyne, United Kingdom
⨯
Charlotte Dean,

Affiliations Leukocyte Biology, National Heart and Lung Institute, Imperial College London, London, United Kingdom, Mammalian Genetics Unit, MRC Harwell, Oxfordshire, United Kingdom
⨯
Bill Chaudhry,

Affiliation Institute of Genetic Medicine, Newcastle University, Centre for Life, Newcastle upon Tyne, United Kingdom
⨯
Deborah J. Henderson

* E-mail: deborah.henderson@ncl.ac.uk

Affiliation Institute of Genetic Medicine, Newcastle University, Centre for Life, Newcastle upon Tyne, United Kingdom
⨯

Vangl2-Regulated Polarisation of Second Heart Field-Derived Cells Is Required for Outflow Tract Lengthening during Cardiac Development

Simon A. Ramsbottom,
Vipul Sharma,
Hong Jun Rhee,
Lorraine Eley,
Helen M. Phillips,
Hannah F. Rigby,
Charlotte Dean,
Bill Chaudhry,
Deborah J. Henderson

Published: December 18, 2014
https://doi.org/10.1371/journal.pgen.1004871

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