Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis

• Jessica LaRusch ,

  Contributed equally to this work with: Jessica LaRusch, Jinsei Jung, Ignacio J. General

  Affiliation Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Jinsei Jung ,

  Contributed equally to this work with: Jessica LaRusch, Jinsei Jung, Ignacio J. General

  Affiliation Department of Pharmacology and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea

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• Ignacio J. General ,

  Contributed equally to this work with: Jessica LaRusch, Jinsei Jung, Ignacio J. General

  Affiliation Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Michele D. Lewis,

  Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, United States of America

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• Hyun Woo Park,

  Current address: Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, California, United States of America

  Affiliation Department of Pharmacology and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea

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• Randall E. Brand,

  Affiliation Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Andres Gelrud,

  Current address: University of Chicago, Chicago, Illinois, United States of America

  Affiliation Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Michelle A. Anderson,

  Affiliation Department of Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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• Peter A. Banks,

  Affiliation Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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• Darwin Conwell,

  Current address: The Ohio State University, Columbus, Ohio, United States of America

  Affiliation Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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• Christopher Lawrence,

  Affiliation Digestive Disease Center, Medical University of South Carolina, Charleston, South Carolina, United States of America

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• Joseph Romagnuolo,

  Affiliation Digestive Disease Center, Medical University of South Carolina, Charleston, South Carolina, United States of America

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• John Baillie,

  Current address: Carteret Medical Group, Morehead City, North Carolina, United States of America

  Affiliation Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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• Samer Alkaade,

  Affiliation Department of Internal Medicine, St. Louis University School of Medicine, St Louis, Missouri, United States of America

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• Gregory Cote,

  Affiliation Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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• Timothy B. Gardner,

  Affiliation Dartmouth-Hitchcock Medical Center, Hanover, New Hampshire, United States of America

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• Stephen T. Amann,

  Affiliation North Mississippi Medical Center, Tupelo, Mississippi, United States of America

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• Adam Slivka,

  Affiliation Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Bimaljit Sandhu,

  Current address: St Mary's Hospital, Richmond, Virginia, United States of America

  Affiliation Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia, United States of America

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• Amy Aloe,

  Affiliation Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Michelle L. Kienholz,

  Affiliation Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Dhiraj Yadav,

  Affiliation Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• M. Michael Barmada,

  Affiliation Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Ivet Bahar ,

  ¶IB, MGL and DCW co-directed this project.

  Affiliation Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Min Goo Lee ,

  ¶IB, MGL and DCW co-directed this project.

  Affiliation Department of Pharmacology and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea

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• David C. Whitcomb ,

  * E-mail: whitcomb@pitt.edu

  ¶IB, MGL and DCW co-directed this project.

  Affiliations Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Cell Biology and Molecular Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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•  [ ... ],
• the North American Pancreatitis Study Group

  ¶‡ Full membership of the North American Pancreatitis Study Group is provided in the Acknowledgments.

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