A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan

• Elizabeth X. Kwan,

  Affiliation Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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• Eric J. Foss,

  Affiliation Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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• Scott Tsuchiyama,

  Affiliation The Buck Institute for Research on Aging, Novato, California, United States of America

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• Gina M. Alvino,

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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• Leonid Kruglyak,

  Affiliation Howard Hughes Medical Institute, Lewis-Sigler Institute for Integrative Genomics, and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America

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• Matt Kaeberlein,

  Affiliation Department of Pathology, University of Washington, Seattle, Washington, United States of America

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• M. K. Raghuraman,

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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• Bonita J. Brewer,

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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• Brian K. Kennedy,

  Affiliation The Buck Institute for Research on Aging, Novato, California, United States of America

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• Antonio Bedalov

  * E-mail: abedalov@fhcrc.org

  Affiliation Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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