The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

Hailong Wang; Linda Z. Shi; Catherine C. L. Wong; Xuemei Han; Patty Yi-Hwa Hwang; Lan N. Truong; Qingyuan Zhu; Zhengping Shao; David J. Chen; Michael W. Berns; John R. Yates III; Longchuan Chen; Xiaohua Wu

doi:10.1371/journal.pgen.1003277

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Open Access

Peer-reviewed

Research Article

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

Hailong Wang,

Affiliation Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Linda Z. Shi,

Affiliation The Institute of Engineering in Medicine, University of California San Diego, La Jolla, California, United States of America
⨯
Catherine C. L. Wong,

Affiliation Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Xuemei Han,

Affiliation Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Patty Yi-Hwa Hwang,

Affiliation Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Lan N. Truong,

Affiliation Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Qingyuan Zhu,

Affiliation The Institute of Engineering in Medicine, University of California San Diego, La Jolla, California, United States of America
⨯
Zhengping Shao,

Affiliation Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
⨯
David J. Chen,

Affiliation Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
⨯
Michael W. Berns,

Affiliation The Institute of Engineering in Medicine, University of California San Diego, La Jolla, California, United States of America
⨯
John R. Yates III,

Affiliation Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Longchuan Chen,

Affiliation Department of Pathology, Veterans Affairs Medical Center, Long Beach, California, United States of America
⨯
Xiaohua Wu

* E-mail: xiaohwu@scripps.edu

Affiliation Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
⨯

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

Hailong Wang,
Linda Z. Shi,
Catherine C. L. Wong,
Xuemei Han,
Patty Yi-Hwa Hwang,
Lan N. Truong,
Qingyuan Zhu,
Zhengping Shao,
David J. Chen,
Michael W. Berns

Published: February 28, 2013
https://doi.org/10.1371/journal.pgen.1003277

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Phosphorylation
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DNA damage
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DNA repair
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Insects
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In vitro kinase assay
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Immunoblotting
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Microhomology-mediated end joining
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Cell cycle and cell division
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