ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy

• Juliette Faraco ,

  Contributed equally to this work with: Juliette Faraco, Ling Lin

  Affiliation Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, California, United States of America

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• Ling Lin ,

  Contributed equally to this work with: Juliette Faraco, Ling Lin

  Affiliation Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, California, United States of America

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• Birgitte Rahbek Kornum,

  Affiliations Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, California, United States of America, Center for Sleep Medicine, Department of Clinical Neurophysiology, Faculty of Health Sciences, University of Copenhagen, Glostrup Hospital, Copenhagen, Denmark

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• Eimear E. Kenny,

  Affiliation Department of Genetics, Stanford University, Palo Alto, California, United States of America

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• Gosia Trynka,

  Affiliation University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands

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• Mali Einen,

  Affiliation Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, California, United States of America

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• Tom J. Rico,

  Affiliation Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, California, United States of America

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• Peter Lichtner,

  Affiliation Institute of Human Genetics, Helmholtz Zentrum München–German Research Center for Environmental Health, Munich, Germany

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• Yves Dauvilliers,

  Affiliations National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), Paris, France, Sleep Unit, Gui-de-Chauliac Hospital, INSERM-1061, Montpellier, France

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• Isabelle Arnulf,

  Affiliations National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), Paris, France, Sleep Disorders Unit, Hospital Pitié-Salpêtrière, Pierre and Marie Curie University, Paris, France

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• Michel Lecendreux,

  Affiliations National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), Paris, France, Centre Pédiatrique des Pathologies du Sommeil, Hôpital Robert Debré, Paris, France

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• Sirous Javidi,

  Affiliations Hephata-Klinik, Schwalmstadt-Treysa, Germany, Department of Neurology, Philipps University of Marburg, Marburg, Germany

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• Peter Geisler,

  Affiliation Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany

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• Geert Mayer,

  Affiliations Hephata-Klinik, Schwalmstadt-Treysa, Germany, Department of Neurology, Philipps University of Marburg, Marburg, Germany

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• Fabio Pizza,

  Affiliation Department of Neurological Sciences, University of Bologna/IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy

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• Francesca Poli,

  Affiliation Department of Neurological Sciences, University of Bologna/IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy

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• Giuseppe Plazzi,

  Affiliations Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, California, United States of America, Department of Neurological Sciences, University of Bologna/IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy

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• Sebastiaan Overeem,

  Affiliation Kempenhaeghe Centre for Sleep Medicine, Heeze, The Netherlands

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• Gert Jan Lammers,

  Affiliation Leiden University Medical Center, Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands

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• David Kemlink,

  Affiliation Department of Neurology, Charles University, 1st Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic

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• Karel Sonka,

  Affiliation Department of Neurology, Charles University, 1st Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic

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• Sona Nevsimalova,

  Affiliation Department of Neurology, Charles University, 1st Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic

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• Guy Rouleau,

  Affiliation CHU Ste-Justine Research Centre, Centre of Excellence in Neuromics, Université de Montréal (CENUM), Montreal, Quebec, Canada

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• Alex Desautels,

  Affiliations Neurology Service, Hôpital du Sacré-Coeur, Université de Montréal, Montréal, Quebec, Canada, Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur, Université de Montréal, Montréal, Québec, Canada

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• Jacques Montplaisir,

  Affiliation Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur, Université de Montréal, Montréal, Québec, Canada

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• Birgit Frauscher,

  Affiliation Department of Neurology, Innsbruck Medical University, Innsbruck, Austria

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• Laura Ehrmann,

  Affiliation Department of Neurology, Innsbruck Medical University, Innsbruck, Austria

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• Birgit Högl,

  Affiliation Department of Neurology, Innsbruck Medical University, Innsbruck, Austria

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• Poul Jennum,

  Affiliation Center for Sleep Medicine, Department of Clinical Neurophysiology, Faculty of Health Sciences, University of Copenhagen, Glostrup Hospital, Copenhagen, Denmark

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• Patrice Bourgin,

  Affiliation University Sleep Clinic and CNRS UPR3212, Strasbourg University Hospital, Strasbourg University, Strasbourg, France

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• Rosa Peraita-Adrados,

  Affiliation Sleep and Epilepsy Unit-Clinical Neurophysiology Service, University Hospital Gregorio Marañón, Madrid, Spain

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• Alex Iranzo,

  Affiliation Neurology Service and Multisciplinary Sleep Unit, Hospital Clínic, CIBERNED, IDIBAPS, Barcelona, Spain

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• Claudio Bassetti,

  Affiliation Department of Neurology, Inselspital Universitatsspital, Bern, Swizerland

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• Wei-Min Chen,

  Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

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• Patrick Concannon,

  Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

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• Susan D. Thompson,

  Affiliation Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

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• Vincent Damotte,

  Affiliations Inserm, U975, CRICM, Paris, France, Pierre Marie Curie University, UMR-S975, Paris, France

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• Bertrand Fontaine,

  Affiliations Inserm, U975, CRICM, Paris, France, Pierre Marie Curie University, UMR-S975, Paris, France, Assistance Publique-Hôpitaux de Paris, Department of Neurology, Hospital Pitié-Salpêtrière, Paris, France

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• Maxime Breban,

  Affiliations Cochin Institute, INSERM U1016/CNRS UMR 8104/Paris Descartes University, Paris, France, Department of Rheumatology, Ambroise Paré Hospital AP-HP, Boulogne-Billancourt, France, Université Versailles Saint Quentin en Yvelines (UVSQ), Boulogne-Billancourt, France

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• Christian Gieger,

  Affiliation Institute of Genetic Epidemiology, Helmholtz Zentrum München, Munich, Germany

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• Norman Klopp,

  Affiliation Institute of Genetic Epidemiology, Helmholtz Zentrum München, Munich, Germany

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• Panos Deloukas,

  Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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• Cisca Wijmenga,

  Affiliation University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands

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• Joachim Hallmayer,

  Affiliations Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, California, United States of America, Department of Psychiatry, Stanford University School of Medicine, Palo Alto, California, United States of America

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• Suna Onengut-Gumuscu,

  Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

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• Stephen S. Rich,

  Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

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• Juliane Winkelmann,

  Affiliations Institute of Human Genetics, Helmholtz Zentrum München–German Research Center for Environmental Health, Munich, Germany, Institute for Human Genetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany, Neurology Clinic, Klinikum rechts der Isar, Technische Universität München, Munich, Germany, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

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•  [ ... ],
• Emmanuel Mignot

  * E-mail: mignot@stanford.edu

  Affiliation Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, California, United States of America

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