A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells

Li Xie; Claude Gazin; Sung Mi Park; Lihua J. Zhu; Marie-anne Debily; Ellen L. W. Kittler; Maria L. Zapp; David Lapointe; Stephane Gobeil; Ching-Man Virbasius; Michael R. Green

doi:10.1371/journal.pgen.1003151

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Open Access

Peer-reviewed

Research Article

A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells

Li Xie ,

Contributed equally to this work with: Li Xie, Claude Gazin

Affiliation Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Claude Gazin ,

Contributed equally to this work with: Li Xie, Claude Gazin

* E-mail: claude.gazin@cea.fr (CG); michael.green@umassmed.edu (MRG)

Affiliations Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, CEA/DSV/iRCM/LEFG, Genopole G2, Evry, France, INSERM U967 and Université Paris Diderot, Evry, France
⨯
Sung Mi Park,

Affiliation Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Lihua J. Zhu,

Affiliation Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Marie-anne Debily,

Affiliations CEA/DSV/iRCM/LEFG, Genopole G2, Evry, France, Université d'Evry Val d'Essonne, Evry, France
⨯
Ellen L. W. Kittler,

Affiliation Program in Molecular Medicine and Center for AIDS Research, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Maria L. Zapp,

Affiliation Program in Molecular Medicine and Center for AIDS Research, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
David Lapointe,

Affiliation Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Stephane Gobeil,

Current address: CRCHUQ-CHUL, Laval University, Quebec City, Québec, Canada

Affiliation Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Ching-Man Virbasius,

Affiliation Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Michael R. Green

* E-mail: claude.gazin@cea.fr (CG); michael.green@umassmed.edu (MRG)

Affiliation Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯

A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells

Li Xie,
Claude Gazin,
Sung Mi Park,
Lihua J. Zhu,
Marie-anne Debily,
Ellen L. W. Kittler,
Maria L. Zapp,
David Lapointe,
Stephane Gobeil,
Ching-Man Virbasius

Published: December 20, 2012
https://doi.org/10.1371/journal.pgen.1003151

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