Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model

• Ya-Chu Chang ,

  Contributed equally to this work with: Ya-Chu Chang, Wan-Tzu Hung

  Affiliation Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan

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• Wan-Tzu Hung ,

  Contributed equally to this work with: Ya-Chu Chang, Wan-Tzu Hung

  Affiliation Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan

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• Yun-Chin Chang,

  Affiliation Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan

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• Henry C. Chang,

  Affiliation Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America

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• Chia-Lin Wu,

  Affiliations Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan, Brain Research Center, National Tsing Hua University, Hsinchu, Taiwan

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• Ann-Shyn Chiang,

  Affiliations Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan, Brain Research Center, National Tsing Hua University, Hsinchu, Taiwan

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• George R. Jackson,

  Affiliations Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, United States of America, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America, Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Tzu-Kang Sang

  * E-mail: tksang@life.nthu.edu.tw

  Affiliations Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan, Brain Research Center, National Tsing Hua University, Hsinchu, Taiwan

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