Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups

• André Scherag ,

  * E-mail: andre.scherag@uk-essen.de (AS); p.froguel@imperial.ac.uk (PF)

  Affiliations Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany, Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany

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• Christian Dina,

  Affiliation Centre National de la Recherche Scientifique (CNRS) 8090-Institute of Biology, Pasteur Institute, Lille, France

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• Anke Hinney,

  Affiliation Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany

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• Vincent Vatin,

  Affiliation Centre National de la Recherche Scientifique (CNRS) 8090-Institute of Biology, Pasteur Institute, Lille, France

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• Susann Scherag,

  Affiliation Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany

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• Carla I. G. Vogel,

  Affiliation Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany

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• Timo D. Müller,

  Affiliations Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany, Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, Ohio, United States of America

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• Harald Grallert,

  Affiliation Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, Munich-Neuherberg, Germany

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• H.-Erich Wichmann,

  Affiliations Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, Munich-Neuherberg, Germany, Institute of Medical Data Management, Biometrics, and Epidemiology, Ludwig-Maximilians University Munich, Munich, Germany

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• Beverley Balkau,

  Affiliation INSERM, CESP Centre for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over the Lifecourse, Université Paris Sud 11, UMRS 1018, Villejuif, France

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• Barbara Heude,

  Affiliation INSERM, CESP Centre for Research in Epidemiology and Population Health, U1018, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over the Lifecourse, Université Paris Sud 11, UMRS 1018, Villejuif, France

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• Marjo-Riitta Jarvelin,

  Affiliations Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom, Institute of Health Sciences, Department of Child and Adolescent Health, National Public Health Institute, Biocenter Oulu, University of Oulu, Oulu, Finland

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• Anna-Liisa Hartikainen,

  Affiliation Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland

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• Claire Levy-Marchal,

  Affiliation INSERM, U690, Université Paris Diderot, Paris, France

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• Jacques Weill,

  Affiliation Pediatric Endocrine Unit, Jeanne de Flandre Hospital, Lille, France

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• Jérôme Delplanque,

  Affiliation Centre National de la Recherche Scientifique (CNRS) 8090-Institute of Biology, Pasteur Institute, Lille, France

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• Antje Körner,

  Affiliation University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany

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• Wieland Kiess,

  Affiliation University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany

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• Peter Kovacs,

  Affiliation Department of Internal Medicine III, Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany

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• Nigel W. Rayner,

  Affiliations Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Inga Prokopenko,

  Affiliations Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Mark I. McCarthy,

  Affiliations Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Helmut Schäfer,

  Affiliation Institute of Medical Biometry and Epidemiology, Philipps-University of Marburg, Marburg, Germany

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• Ivonne Jarick,

  Affiliation Institute of Medical Biometry and Epidemiology, Philipps-University of Marburg, Marburg, Germany

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• Heiner Boeing,

  Affiliation Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany

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• Eva Fisher,

  Affiliation Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany

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• Thomas Reinehr,

  Affiliation Institute for Paediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten/Herdecke, Datteln, Germany

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• Joachim Heinrich,

  Affiliations Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, Munich-Neuherberg, Germany, Institute of Medical Data Management, Biometrics, and Epidemiology, Ludwig-Maximilians University Munich, Munich, Germany

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• Peter Rzehak,

  Affiliations Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, Munich-Neuherberg, Germany, Institute of Medical Data Management, Biometrics, and Epidemiology, Ludwig-Maximilians University Munich, Munich, Germany

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• Dietrich Berdel,

  Affiliation Department of Paediatrics, Marien-Hospital Wesel, Wesel, Germany

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• Michael Borte,

  Affiliations Children's Hospital, Municipal Hospital “St Georg”, Leipzig, Germany, Department of Pediatrics, University of Leipzig, Leipzig, Germany

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• Heike Biebermann,

  Affiliation Institute of Experimental Pediatric Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany

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• Heiko Krude,

  Affiliation Institute of Experimental Pediatric Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany

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• Dieter Rosskopf,

  Affiliation Institute for Pharmacology, Ernst-Moritz-Arndt University, Greifswald, Germany

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• Christian Rimmbach,

  Affiliation Institute for Pharmacology, Ernst-Moritz-Arndt University, Greifswald, Germany

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• Winfried Rief,

  Affiliation Department of Clinical Psychology and Psychotherapy, Faculty of Psychology, University of Marburg, Germany

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• Tobias Fromme,

  Affiliation Molecular Nutritional Medicine, Technische Universität München, Else Kröner-Fresenius Center, Freising-Weihenstephan, Germany

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• Martin Klingenspor,

  Affiliation Molecular Nutritional Medicine, Technische Universität München, Else Kröner-Fresenius Center, Freising-Weihenstephan, Germany

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• Annette Schürmann,

  Affiliation Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

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• Nadja Schulz,

  Affiliation Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

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• Markus M. Nöthen,

  Affiliations Institute of Human Genetics, University of Bonn, Bonn, Germany, Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany

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• Thomas W. Mühleisen,

  Affiliations Institute of Human Genetics, University of Bonn, Bonn, Germany, Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany

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• Raimund Erbel,

  Affiliation Department of Cardiology, University of Duisburg-Essen, Essen, Germany

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• Karl-Heinz Jöckel,

  Affiliation Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany

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• Susanne Moebus,

  Affiliation Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany

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• Tanja Boes,

  Affiliation Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany

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• Thomas Illig,

  Affiliations Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, Munich-Neuherberg, Germany, Institute of Medical Data Management, Biometrics, and Epidemiology, Ludwig-Maximilians University Munich, Munich, Germany

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• Philippe Froguel ,

  * E-mail: andre.scherag@uk-essen.de (AS); p.froguel@imperial.ac.uk (PF)

  Affiliations Centre National de la Recherche Scientifique (CNRS) 8090-Institute of Biology, Pasteur Institute, Lille, France, Department of Genomic Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom

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• Johannes Hebebrand,

  Affiliation Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany

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•  [ ... ],
• David Meyre

  Affiliation Centre National de la Recherche Scientifique (CNRS) 8090-Institute of Biology, Pasteur Institute, Lille, France

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