A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose

Fumihiko Takeuchi; Ralph McGinnis; Stephane Bourgeois; Chris Barnes; Niclas Eriksson; Nicole Soranzo; Pamela Whittaker; Venkatesh Ranganath; Vasudev Kumanduri; William McLaren; Lennart Holm; Jonatan Lindh; Anders Rane; Mia Wadelius; Panos Deloukas

doi:10.1371/journal.pgen.1000433

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Peer-reviewed

Research Article

A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose

Fumihiko Takeuchi ,

Contributed equally to this work with: Fumihiko Takeuchi, Ralph McGinnis

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Ralph McGinnis ,

Contributed equally to this work with: Fumihiko Takeuchi, Ralph McGinnis

* E-mail: rm2@sanger.ac.uk (RM); panos@sanger.ac.uk (PD)

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Stephane Bourgeois,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Chris Barnes,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Niclas Eriksson,

Affiliation Uppsala Clinical Research Centre, Uppsala, Sweden
⨯
Nicole Soranzo,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Pamela Whittaker,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Venkatesh Ranganath,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Vasudev Kumanduri,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
William McLaren,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Lennart Holm,

Affiliation Department of Clinical Pharmacology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
⨯
Jonatan Lindh,

Affiliation Department of Clinical Pharmacology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
⨯
Anders Rane,

Affiliation Department of Clinical Pharmacology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
⨯
Mia Wadelius,

Affiliation Department of Medical Sciences, Clinical Pharmacology, Uppsala University Hospital, Uppsala, Sweden
⨯
Panos Deloukas

* E-mail: rm2@sanger.ac.uk (RM); panos@sanger.ac.uk (PD)

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯

A Genome-Wide Association Study Confirms VKORC1, CYP2C9, and CYP4F2 as Principal Genetic Determinants of Warfarin Dose

Fumihiko Takeuchi,
Ralph McGinnis,
Stephane Bourgeois,
Chris Barnes,
Niclas Eriksson,
Nicole Soranzo,
Pamela Whittaker,
Venkatesh Ranganath,
Vasudev Kumanduri,
William McLaren

Published: March 20, 2009
https://doi.org/10.1371/journal.pgen.1000433

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