About the Authors

Fumihiko Takeuchi

Contributed equally to this work with: Fumihiko Takeuchi, Ralph McGinnis

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Ralph McGinnis

Contributed equally to this work with: Fumihiko Takeuchi, Ralph McGinnis

rm2@sanger.ac.uk (RM); panos@sanger.ac.uk (PD)

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Stephane Bourgeois

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Chris Barnes

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Niclas Eriksson

Affiliation Uppsala Clinical Research Centre, Uppsala, Sweden

Nicole Soranzo

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Pamela Whittaker

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Venkatesh Ranganath

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Vasudev Kumanduri

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

William McLaren

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Lennart Holm

Affiliation Department of Clinical Pharmacology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

Jonatan Lindh

Affiliation Department of Clinical Pharmacology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

Anders Rane

Affiliation Department of Clinical Pharmacology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

Mia Wadelius

Affiliation Department of Medical Sciences, Clinical Pharmacology, Uppsala University Hospital, Uppsala, Sweden

Panos Deloukas

rm2@sanger.ac.uk (RM); panos@sanger.ac.uk (PD)

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MW PD. Performed the experiments: SB CB NE NS PW VR VK. Analyzed the data: FT RM. Contributed reagents/materials/analysis tools: WM AR MW PD. Wrote the paper: FT RM. Assembled clinical data: NE LH JL AR MW.