Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms

• Guangju Zhai ,

  Contributed equally to this work with: Guangju Zhai, Alexander Teumer, Lisette Stolk, John R. B. Perry, Liesbeth Vandenput, Andrea D. Coviello, Annemarie Koster

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• Alexander Teumer ,

  Contributed equally to this work with: Guangju Zhai, Alexander Teumer, Lisette Stolk, John R. B. Perry, Liesbeth Vandenput, Andrea D. Coviello, Annemarie Koster

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

  ⨯
• Lisette Stolk ,

  Contributed equally to this work with: Guangju Zhai, Alexander Teumer, Lisette Stolk, John R. B. Perry, Liesbeth Vandenput, Andrea D. Coviello, Annemarie Koster

  Affiliations Department of Internal Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands, Netherlands Consortium of Healthy Ageing, Rotterdam, The Netherlands

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• John R. B. Perry ,

  Contributed equally to this work with: Guangju Zhai, Alexander Teumer, Lisette Stolk, John R. B. Perry, Liesbeth Vandenput, Andrea D. Coviello, Annemarie Koster

  Affiliations Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

  ⨯
• Liesbeth Vandenput ,

  Contributed equally to this work with: Guangju Zhai, Alexander Teumer, Lisette Stolk, John R. B. Perry, Liesbeth Vandenput, Andrea D. Coviello, Annemarie Koster

  Affiliation Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

  ⨯
• Andrea D. Coviello ,

  Contributed equally to this work with: Guangju Zhai, Alexander Teumer, Lisette Stolk, John R. B. Perry, Liesbeth Vandenput, Andrea D. Coviello, Annemarie Koster

  Affiliation Sections of General Internal Medicine, Preventive Medicine, Cardiology and Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

  ⨯
• Annemarie Koster ,

  Contributed equally to this work with: Guangju Zhai, Alexander Teumer, Lisette Stolk, John R. B. Perry, Liesbeth Vandenput, Andrea D. Coviello, Annemarie Koster

  Affiliation Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, United States of America

  ⨯
• Jordana T. Bell,

  Affiliations Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

  ⨯
• Shalender Bhasin,

  Affiliation Section of Endocrinology, Diabetes, and Nutrition, Claude D. Pepper Older Americans Independence Center, Boston University School of Medicine, Boston, Massachusetts, United States of America

  ⨯
• Joel Eriksson,

  Affiliation Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

  ⨯
• Anna Eriksson,

  Affiliation Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

  ⨯
• Florian Ernst,

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

  ⨯
• Luigi Ferrucci,

  Affiliation Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America

  ⨯
• Timothy M. Frayling,

  Affiliation Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

  ⨯
• Daniel Glass,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

  ⨯
• Elin Grundberg,

  Affiliations Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Wellcome Trust Sanger Institute, Hixton, United Kingdom

  ⨯
• Robin Haring,

  Affiliation Institute for Clinical Chemistry and Laboratory Medicine, University of Greifswald, Greifswald, Germany

  ⨯
• Åsa K. Hedman,

  Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

  ⨯
• Albert Hofman,

  Affiliations Netherlands Consortium of Healthy Ageing, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands

  ⨯
• Douglas P. Kiel,

  Affiliation Hebrew Senior Life Institute for Aging Research and Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Heyo K. Kroemer,

  Affiliation Center of Pharmacology and Experimental Therapeutics, Department of Pharmacology, University of Greifswald, Greifswald, Germany

  ⨯
• Yongmei Liu,

  Affiliation Department of Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

  ⨯
• Kathryn L. Lunetta,

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Marcello Maggio,

  Affiliation Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy

  ⨯
• Mattias Lorentzon,

  Affiliation Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

  ⨯
• Massimo Mangino,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

  ⨯
• David Melzer,

  Affiliation Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

  ⨯
• Iva Miljkovic,

  Affiliation Department of Epidemiology, University of Pittsburgh, Pittsburg, Pennsylvania, United States of America

  ⨯
• MuTHER Consortium,
• Alexandra Nica,

  Affiliations Wellcome Trust Sanger Institute, Hixton, United Kingdom, Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland

  ⨯
• Brenda W. J. H. Penninx,

  Affiliation Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands

  ⨯
• Ramachandran S. Vasan,

  Affiliations Sections of General Internal Medicine, Preventive Medicine, Cardiology and Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America

  ⨯
• Fernando Rivadeneira,

  Affiliations Department of Internal Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands, Netherlands Consortium of Healthy Ageing, Rotterdam, The Netherlands

  ⨯
• Kerrin S. Small,

  Affiliations Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Wellcome Trust Sanger Institute, Hixton, United Kingdom

  ⨯
• Nicole Soranzo,

  Affiliations Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Wellcome Trust Sanger Institute, Hixton, United Kingdom

  ⨯
• André G. Uitterlinden,

  Affiliations Department of Internal Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands, Netherlands Consortium of Healthy Ageing, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands

  ⨯
• Henry Völzke,

  Affiliation Institute for Community Medicine, University of Greifswald, Greifswald, Germany

  ⨯
• Scott G. Wilson,

  Affiliations Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Australia, School of Medicine and Pharmacology, University of Western Australia, Nedlands, Australia

  ⨯
• Li Xi,

  Affiliation Molecular Medicine – Computational Biology, Pfizer Worldwide R&D, Groton, Connecticut, United States of America

  ⨯
• Wei Vivian Zhuang,

  Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Tamara B. Harris ,

  ¶These senior authors were joint senior authors on this work.

  Affiliation Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, United States of America

  ⨯
• Joanne M. Murabito ,

  ¶These senior authors were joint senior authors on this work.

  Affiliations Sections of General Internal Medicine, Preventive Medicine, Cardiology and Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America

  ⨯
• Claes Ohlsson ,

  ¶These senior authors were joint senior authors on this work.

  Affiliation Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

  ⨯
• Anna Murray ,

  ¶These senior authors were joint senior authors on this work.

  Affiliation Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom

  ⨯
• Frank H. de Jong ,

  ¶These senior authors were joint senior authors on this work.

  Affiliation Department of Internal Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands

  ⨯
• Tim D. Spector ,

  * E-mail: tim.spector@kcl.ac.uk

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

  ⨯
•  [ ... ],
• Henri Wallaschofski

  ¶These senior authors were joint senior authors on this work.

  Affiliation Institute for Clinical Chemistry and Laboratory Medicine, University of Greifswald, Greifswald, Germany

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